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DOI: 10.4230/DFU.Vol2.SciViz.2011.103
URN: urn:nbn:de:0030-drops-32895
URL: http://drops.dagstuhl.de/opus/volltexte/2011/3289/

Hering-Bertram, Martin ; Siedow, Norbert ; Tse, Oliver ; Plontke, Stefan K. ; Gill, Ruth

Simulation and Visualization of Medical Application to the Inner Ear of the Guinea Pig to Reduce Animal Experiments

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Abstract

We present a novel approach to simulate drug application to the inner ear of the guinea pig with the goal to reduce animal experiments and to increase the accuracy of measurements. The framework is based on a tetrahedral grid representing the individual compartments of the cochlea, associated with a finite element model used to simulate medical diffusion and clearance. In a first simulation scenario, we were able to compute transfer coefficients between the inner compartments of the ear, validating experiments from the literature, and to prove the existence of clearance at the inner scala tympani. In a second scenario, the cochlea was unwound to obtain a one-dimensional model for efficient simulation-based transfer coefficient identification. These coefficients are useful to predict the impact of novel medication application systems.

BibTeX - Entry

@InCollection{heringbertram_et_al:DFU:2011:3289,
  author =	{Martin Hering-Bertram and Norbert Siedow and Oliver Tse and Stefan K. Plontke and Ruth Gill},
  title =	{{Simulation and Visualization of Medical Application to the Inner Ear of the Guinea Pig to Reduce Animal Experiments}},
  booktitle =	{Scientific Visualization: Interactions, Features, Metaphors},
  pages =	{103--117},
  series =	{Dagstuhl Follow-Ups},
  ISBN =	{978-3-939897-26-2},
  ISSN =	{1868-8977},
  year =	{2011},
  volume =	{2},
  editor =	{Hans Hagen},
  publisher =	{Schloss Dagstuhl--Leibniz-Zentrum fuer Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{http://drops.dagstuhl.de/opus/volltexte/2011/3289},
  URN =		{urn:nbn:de:0030-drops-32895},
  doi =		{http://dx.doi.org/10.4230/DFU.Vol2.SciViz.2011.103},
  annote =	{Keywords: Cochlea, Perilymph, Spiral Ligament, Round Window Application, Modiolar Communication Routes, Numerical Simulation, Parameter Identification}
}

Keywords: Cochlea, Perilymph, Spiral Ligament, Round Window Application, Modiolar Communication Routes, Numerical Simulation, Parameter Identification
Seminar: Scientific Visualization: Interactions, Features, Metaphors
Issue date: 2011
Date of publication: 26.10.2011


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