We study a Multiple Depot Heterogeneous Traveling Salesman Problem (MDHTSP) where the cost of the traveling between any two targets depends on the type of the vehicle. The travel costs are assumed to be symmetric, satisfy the triangle inequality, and are monotonic, i.e., the travel costs between any two targets monotonically increases with the index of the vehicles. Exploiting the monotonic structure of the travel costs, we present a 2-approximation algorithm based on the primal-dual method.