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Analyzing various models of Circadian Clock and Cell Cycle coupling Csikász-Nagy, Attila Faure, Adrien Larcher, Roberto Lecca, Paola Mura, Ivan Jordan, Ferenc Palmisano, Alida Romanel, Alessandro Sedwards, Sean Siebert, Heike Soliman, Sylvain Thieffry, Denis Zámborszky, Judit Mazza, Tommaso Ballarini, Paolo Cell cycle circadian clock computational modelling The daily rhythm can influence the proliferation rate of many cell types. In the mammalian system the transcription of the cell cycle regulatory protein Wee1 is controlled by the circadian clock. Zamborszky et al. (2007) present a computational model coupling the cell cycle and circadian rhythm, showing that this coupling can lead to multimodal cell cycle time distributions. Biological data points to additional couplings, including a link back from the cell cycle to the circadian clock. Proper modelling of this coupling requires a more detailed description of both parts of the model. Hence, we aim at further extending and analysing earlier models using a combination of modelling techniques and computer software, including CoSBI lab, BIOCHAM, and GINsim. Schloss Dagstuhl – Leibniz-Zentrum für Informatik Attila Csikász-Nagy and Adrien Faure and Roberto Larcher and Paola Lecca and Ivan Mura and Ferenc Jordan and Alida Palmisano and Alessandro Romanel and Sean Sedwards and Heike Siebert and Sylvain Soliman and Denis Thieffry and Judit Zámborszky and Tommaso Mazza and Paolo Ballarini 2009 Is Part Of Dagstuhl Seminar Proceedings, Volume 9091, Formal Methods in Molecular Biology (2009) InProceedings Text doc-type:ResearchArticle publishedVersion application/pdf doi:10.4230/DagSemProc.09091.3 urn:nbn:de:0030-drops-19944 https://drops.dagstuhl.de/entities/document/10.4230/DagSemProc.09091.3 eng https://creativecommons.org/licenses/by/4.0/legalcode