2 Search Results for "EL-Sanosi, Ibrahim"

Document
DOI: 10.4230/LIPIcs.WABI.2021.15
BISER: Fast Characterization of Segmental Duplication Structure in Multiple Genome Assemblies

Authors: Hamza Išerić, Can Alkan, Faraz Hach, and Ibrahim Numanagić

Published in: LIPIcs, Volume 201, 21st International Workshop on Algorithms in Bioinformatics (WABI 2021)

Abstract
The increasing availability of high-quality genome assemblies raised interest in the characterization of genomic architecture. Major architectural parts, such as common repeats and segmental duplications (SDs), increase genome plasticity that stimulates further evolution by changing the genomic structure. However, optimal computation of SDs through standard local alignment algorithms is impractical due to the size of most genomes. A cross-genome evolutionary analysis of SDs is even harder, as one needs to characterize SDs in multiple genomes and find relations between those SDs and unique segments in other genomes. Thus there is a need for fast and accurate algorithms to characterize SD structure in multiple genome assemblies to better understand the evolutionary forces that shaped the genomes of today. Here we introduce a new tool, BISER, to quickly detect SDs in multiple genomes and identify elementary SDs and core duplicons that drive the formation of such SDs. BISER improves earlier tools by (i) scaling the detection of SDs with low homology (75%) to multiple genomes while introducing further 8-24x speed-ups over the existing tools, and by (ii) characterizing elementary SDs and detecting core duplicons to help trace the evolutionary history of duplications to as far as 90 million years.
Cite as

Hamza Išerić, Can Alkan, Faraz Hach, and Ibrahim Numanagić. BISER: Fast Characterization of Segmental Duplication Structure in Multiple Genome Assemblies. In 21st International Workshop on Algorithms in Bioinformatics (WABI 2021). Leibniz International Proceedings in Informatics (LIPIcs), Volume 201, pp. 15:1-15:18, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2021)

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@InProceedings{iseric_et_al:LIPIcs.WABI.2021.15,
  author =	{I\v{s}eri\'{c}, Hamza and Alkan, Can and Hach, Faraz and Numanagi\'{c}, Ibrahim},
  title =	{{BISER: Fast Characterization of Segmental Duplication Structure in Multiple Genome Assemblies}},
  booktitle =	{21st International Workshop on Algorithms in Bioinformatics (WABI 2021)},
  pages =	{15:1--15:18},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-200-6},
  ISSN =	{1868-8969},
  year =	{2021},
  volume =	{201},
  editor =	{Carbone, Alessandra and El-Kebir, Mohammed},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2021.15},
  URN =		{urn:nbn:de:0030-drops-143681},
  doi =		{10.4230/LIPIcs.WABI.2021.15},
  annote =	{Keywords: genome analysis, fast alignment, segmental duplications, core duplicons, sequence decomposition}
}
Document
DOI: 10.4230/OASIcs.ICCSW.2017.3
Improving the Latency and Throughput of ZooKeeper Atomic Broadcast

Authors: Ibrahim EL-Sanosi and Paul Ezhilchelvan

Published in: OASIcs, Volume 60, 2017 Imperial College Computing Student Workshop (ICCSW 2017)

Abstract
ZooKeeper is a crash-tolerant system that offers fundamental services to Internet-scale applications, thereby reducing the development and hosting of the latter. It consists of >3 servers that form a replicated state machine. Maintaining these replicas in a mutually consistent state requires executing an Atomic Broadcast Protocol, Zab, so that concurrent requests for state changes are serialised identically at all replicas before being acted upon. Thus, ZooKeeper performance for update operations is determined by Zab performance. We contribute by presenting two easy-to-implement Zab variants, called ZabAC and ZabAA. They are designed to offer small atomic-broadcast latencies and to reduce the processing load on the primary node that plays a leading role in Zab. The former improves ZooKeeper performance and the latter enables ZooKeeper to face more challenging load conditions.
Cite as

Ibrahim EL-Sanosi and Paul Ezhilchelvan. Improving the Latency and Throughput of ZooKeeper Atomic Broadcast. In 2017 Imperial College Computing Student Workshop (ICCSW 2017). Open Access Series in Informatics (OASIcs), Volume 60, pp. 3:1-3:10, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2018)

Copy BibTex To Clipboard

@InProceedings{elsanosi_et_al:OASIcs.ICCSW.2017.3,
  author =	{EL-Sanosi, Ibrahim and Ezhilchelvan, Paul},
  title =	{{Improving the Latency and Throughput of ZooKeeper Atomic Broadcast}},
  booktitle =	{2017 Imperial College Computing Student Workshop (ICCSW 2017)},
  pages =	{3:1--3:10},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-059-0},
  ISSN =	{2190-6807},
  year =	{2018},
  volume =	{60},
  editor =	{Leahy, Fergus and Franco, Juliana},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops-dev.dagstuhl.de/entities/document/10.4230/OASIcs.ICCSW.2017.3},
  URN =		{urn:nbn:de:0030-drops-84452},
  doi =		{10.4230/OASIcs.ICCSW.2017.3},
  annote =	{Keywords: Atomic Broadcast, Server Replication, Protocol Latency, Throughput}
}
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