2 Search Results for "Gardner, Kevin"

Document
DOI: 10.4230/LIPIcs.SoCG.2020.11
Persistent Homology Based Characterization of the Breast Cancer Immune Microenvironment: A Feasibility Study

Authors: Andrew Aukerman, Mathieu Carrière, Chao Chen, Kevin Gardner, Raúl Rabadán, and Rami Vanguri

Published in: LIPIcs, Volume 164, 36th International Symposium on Computational Geometry (SoCG 2020)

Abstract
Persistent homology is a common tool of topological data analysis, whose main descriptor, the persistence diagram, aims at computing and encoding the geometry and topology of given datasets. In this article, we present a novel application of persistent homology to characterize the spatial arrangement of immune and epithelial (tumor) cells within the breast cancer immune microenvironment. More specifically, quantitative and robust characterizations are built by computing persistence diagrams out of a staining technique (quantitative multiplex immunofluorescence) which allows us to obtain spatial coordinates and stain intensities on individual cells. The resulting persistence diagrams are evaluated as characteristic biomarkers of cancer subtype and prognostic biomarker of overall survival. For a cohort of approximately 700 breast cancer patients with median 8.5-year clinical follow-up, we show that these persistence diagrams outperform and complement the usual descriptors which capture spatial relationships with nearest neighbor analysis. This provides new insights and possibilities on the general problem of building (topology-based) biomarkers that are characteristic and predictive of cancer subtype, overall survival and response to therapy.
Cite as

Andrew Aukerman, Mathieu Carrière, Chao Chen, Kevin Gardner, Raúl Rabadán, and Rami Vanguri. Persistent Homology Based Characterization of the Breast Cancer Immune Microenvironment: A Feasibility Study. In 36th International Symposium on Computational Geometry (SoCG 2020). Leibniz International Proceedings in Informatics (LIPIcs), Volume 164, pp. 11:1-11:20, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2020)

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@InProceedings{aukerman_et_al:LIPIcs.SoCG.2020.11,
  author =	{Aukerman, Andrew and Carri\`{e}re, Mathieu and Chen, Chao and Gardner, Kevin and Rabad\'{a}n, Ra\'{u}l and Vanguri, Rami},
  title =	{{Persistent Homology Based Characterization of the Breast Cancer Immune Microenvironment: A Feasibility Study}},
  booktitle =	{36th International Symposium on Computational Geometry (SoCG 2020)},
  pages =	{11:1--11:20},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-143-6},
  ISSN =	{1868-8969},
  year =	{2020},
  volume =	{164},
  editor =	{Cabello, Sergio and Chen, Danny Z.},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops-dev.dagstuhl.de/entities/document/10.4230/LIPIcs.SoCG.2020.11},
  URN =		{urn:nbn:de:0030-drops-121695},
  doi =		{10.4230/LIPIcs.SoCG.2020.11},
  annote =	{Keywords: Topological data analysis, persistence diagrams}
}
Document
DOI: 10.4230/OASIcs.CMN.2013.36
The Disappearance of Moral Choice in Serially Reproduced Narratives

Authors: Fritz Breithaupt, Kevin M. Gardner, John K. Kruschke, Torrin M. Liddell, and Samuel Zorowitz

Published in: OASIcs, Volume 32, 2013 Workshop on Computational Models of Narrative

Abstract
How do narratives influence moral decision-making? Our ongoing studies use serial reproduction of narratives, that is multiple retellings as in the telephone game, of morally ambiguous situations. In particular, we tested stories that include a minor misdemeanor, but leave open whether the wrongdoer will be punished by a bystander. It turns out that serial reproduction (retelling) of stories tends to eliminate the possibility of intervention by the bystander under certain conditions. We reason that this effect can be explained either by preferences of the readers or by the reader's discomfort to get involved. A second finding is that retellings of third-person narratives of moral situations lead to a higher degree of change and invention of the outcome than first-person narratives.
Cite as

Fritz Breithaupt, Kevin M. Gardner, John K. Kruschke, Torrin M. Liddell, and Samuel Zorowitz. The Disappearance of Moral Choice in Serially Reproduced Narratives. In 2013 Workshop on Computational Models of Narrative. Open Access Series in Informatics (OASIcs), Volume 32, pp. 36-42, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2013)

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@InProceedings{breithaupt_et_al:OASIcs.CMN.2013.36,
  author =	{Breithaupt, Fritz and Gardner, Kevin M. and Kruschke, John K. and Liddell, Torrin M. and Zorowitz, Samuel},
  title =	{{The Disappearance of Moral Choice in Serially Reproduced Narratives}},
  booktitle =	{2013 Workshop on Computational Models of Narrative},
  pages =	{36--42},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-939897-57-6},
  ISSN =	{2190-6807},
  year =	{2013},
  volume =	{32},
  editor =	{Finlayson, Mark A. and Fisseni, Bernhard and L\"{o}we, Benedikt and Meister, Jan Christoph},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops-dev.dagstuhl.de/entities/document/10.4230/OASIcs.CMN.2013.36},
  URN =		{urn:nbn:de:0030-drops-41386},
  doi =		{10.4230/OASIcs.CMN.2013.36},
  annote =	{Keywords: Narrative, moral stories, side taking, serial reproduction, first-person versus third person narrative}
}
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