Schloss Dagstuhl - Leibniz-Zentrum für Informatik GmbH Schloss Dagstuhl - Leibniz-Zentrum für Informatik GmbH scholarly article en Csikász-Nagy, Attila; Faure, Adrien; Larcher, Roberto; Lecca, Paola; Mura, Ivan; Jordan, Ferenc; Palmisano, Alida; Romanel, Alessandro; Sedwards, Sean; Siebert, Heike; Soliman, Sylvain; Thieffry, Denis; Zámborszky, Judit; Mazza, Tommaso; Ballarini, Paolo License: Creative Commons Attribution 4.0 license (CC BY 4.0)
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URN: urn:nbn:de:0030-drops-19944

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Analyzing various models of Circadian Clock and Cell Cycle coupling



The daily rhythm can influence the proliferation rate of many cell types.
In the mammalian system the transcription of the cell cycle regulatory
protein Wee1 is controlled by the circadian clock. Zamborszky et al.
(2007) present a computational model coupling the cell cycle and circadian
rhythm, showing that this coupling can lead to multimodal cell cycle time
distributions. Biological data points to additional couplings, including a
link back from the cell cycle to the circadian clock. Proper modelling of
this coupling requires a more detailed description of both parts of the
model. Hence, we aim at further extending and analysing earlier models
using a combination of modelling techniques and computer software,
including CoSBI lab, BIOCHAM, and GINsim.

BibTeX - Entry

  author =	{Csik\'{a}sz-Nagy, Attila and Faure, Adrien and Larcher, Roberto and Lecca, Paola and Mura, Ivan and Jordan, Ferenc and Palmisano, Alida and Romanel, Alessandro and Sedwards, Sean and Siebert, Heike and Soliman, Sylvain and Thieffry, Denis and Z\'{a}mborszky, Judit and Mazza, Tommaso and Ballarini, Paolo},
  title =	{{Analyzing various models of Circadian Clock and Cell Cycle coupling}},
  booktitle =	{Formal Methods in Molecular Biology},
  pages =	{1--6},
  series =	{Dagstuhl Seminar Proceedings (DagSemProc)},
  ISSN =	{1862-4405},
  year =	{2009},
  volume =	{9091},
  editor =	{Rainer Breitling and David Roger Gilbert and Monika Heiner and Corrado Priami},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{},
  URN =		{urn:nbn:de:0030-drops-19944},
  doi =		{10.4230/DagSemProc.09091.3},
  annote =	{Keywords: Cell cycle, circadian clock, computational modelling}

Keywords: Cell cycle, circadian clock, computational modelling
Seminar: 09091 - Formal Methods in Molecular Biology
Issue date: 2009
Date of publication: 05.05.2009

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