2 Search Results for "Rabadán, Raúl"


Document
Efficient Computation of Topological Integral Transforms

Authors: Vadim Lebovici, Steve Oudot, and Hugo Passe

Published in: LIPIcs, Volume 301, 22nd International Symposium on Experimental Algorithms (SEA 2024)


Abstract
Topological integral transforms have found many applications in shape analysis, from prediction of clinical outcomes in brain cancer to analysis of barley seeds. Using Euler characteristic as a measure, these objects record rich geometric information on weighted polytopal complexes. While some implementations exist, they only enable discretized representations of the transforms, and they do not handle weighted complexes (such as for instance images). Moreover, recent hybrid transforms lack an implementation. In this paper, we introduce eucalc, a novel implementation of three topological integral transforms - the Euler characteristic transform, the Radon transform, and hybrid transforms - for weighted cubical complexes. Leveraging piecewise linear Morse theory and Euler calculus, the algorithms significantly reduce computational complexity by focusing on critical points. Our software provides exact representations of transforms, handles both binary and grayscale images, and supports multi-core processing. It is publicly available as a C++ library with a Python wrapper. We present mathematical foundations, implementation details, and experimental evaluations, demonstrating eucalc’s efficiency.

Cite as

Vadim Lebovici, Steve Oudot, and Hugo Passe. Efficient Computation of Topological Integral Transforms. In 22nd International Symposium on Experimental Algorithms (SEA 2024). Leibniz International Proceedings in Informatics (LIPIcs), Volume 301, pp. 22:1-22:19, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2024)


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@InProceedings{lebovici_et_al:LIPIcs.SEA.2024.22,
  author =	{Lebovici, Vadim and Oudot, Steve and Passe, Hugo},
  title =	{{Efficient Computation of Topological Integral Transforms}},
  booktitle =	{22nd International Symposium on Experimental Algorithms (SEA 2024)},
  pages =	{22:1--22:19},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-325-6},
  ISSN =	{1868-8969},
  year =	{2024},
  volume =	{301},
  editor =	{Liberti, Leo},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.SEA.2024.22},
  URN =		{urn:nbn:de:0030-drops-203878},
  doi =		{10.4230/LIPIcs.SEA.2024.22},
  annote =	{Keywords: Topological data analysis, Euler calculus, Topological integral transform, Euler characteristic transform, Hybrid transforms}
}
Document
Persistent Homology Based Characterization of the Breast Cancer Immune Microenvironment: A Feasibility Study

Authors: Andrew Aukerman, Mathieu Carrière, Chao Chen, Kevin Gardner, Raúl Rabadán, and Rami Vanguri

Published in: LIPIcs, Volume 164, 36th International Symposium on Computational Geometry (SoCG 2020)


Abstract
Persistent homology is a common tool of topological data analysis, whose main descriptor, the persistence diagram, aims at computing and encoding the geometry and topology of given datasets. In this article, we present a novel application of persistent homology to characterize the spatial arrangement of immune and epithelial (tumor) cells within the breast cancer immune microenvironment. More specifically, quantitative and robust characterizations are built by computing persistence diagrams out of a staining technique (quantitative multiplex immunofluorescence) which allows us to obtain spatial coordinates and stain intensities on individual cells. The resulting persistence diagrams are evaluated as characteristic biomarkers of cancer subtype and prognostic biomarker of overall survival. For a cohort of approximately 700 breast cancer patients with median 8.5-year clinical follow-up, we show that these persistence diagrams outperform and complement the usual descriptors which capture spatial relationships with nearest neighbor analysis. This provides new insights and possibilities on the general problem of building (topology-based) biomarkers that are characteristic and predictive of cancer subtype, overall survival and response to therapy.

Cite as

Andrew Aukerman, Mathieu Carrière, Chao Chen, Kevin Gardner, Raúl Rabadán, and Rami Vanguri. Persistent Homology Based Characterization of the Breast Cancer Immune Microenvironment: A Feasibility Study. In 36th International Symposium on Computational Geometry (SoCG 2020). Leibniz International Proceedings in Informatics (LIPIcs), Volume 164, pp. 11:1-11:20, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2020)


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@InProceedings{aukerman_et_al:LIPIcs.SoCG.2020.11,
  author =	{Aukerman, Andrew and Carri\`{e}re, Mathieu and Chen, Chao and Gardner, Kevin and Rabad\'{a}n, Ra\'{u}l and Vanguri, Rami},
  title =	{{Persistent Homology Based Characterization of the Breast Cancer Immune Microenvironment: A Feasibility Study}},
  booktitle =	{36th International Symposium on Computational Geometry (SoCG 2020)},
  pages =	{11:1--11:20},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-143-6},
  ISSN =	{1868-8969},
  year =	{2020},
  volume =	{164},
  editor =	{Cabello, Sergio and Chen, Danny Z.},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.SoCG.2020.11},
  URN =		{urn:nbn:de:0030-drops-121695},
  doi =		{10.4230/LIPIcs.SoCG.2020.11},
  annote =	{Keywords: Topological data analysis, persistence diagrams}
}
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