The Bourque Distances for Mutation Trees of Cancers

Authors Katharina Jahn, Niko Beerenwinkel, Louxin Zhang



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Katharina Jahn
  • Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland
  • SIB Swiss Institute of Bioinformatics, Basel, Switzerland
Niko Beerenwinkel
  • Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland
  • SIB Swiss Institute of Bioinformatics, Basel, Switzerland
Louxin Zhang
  • Department of Mathematics and Computational Biology Program, National University of Singapore, Singapore

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Katharina Jahn, Niko Beerenwinkel, and Louxin Zhang. The Bourque Distances for Mutation Trees of Cancers. In 20th International Workshop on Algorithms in Bioinformatics (WABI 2020). Leibniz International Proceedings in Informatics (LIPIcs), Volume 172, pp. 14:1-14:22, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2020)
https://doi.org/10.4230/LIPIcs.WABI.2020.14

Abstract

Mutation trees are rooted trees of arbitrary node degree in which each node is labeled with a mutation set. These trees, also referred to as clonal trees, are used in computational oncology to represent the mutational history of tumours. Classical tree metrics such as the popular Robinson - Foulds distance are of limited use for the comparison of mutation trees. One reason is that mutation trees inferred with different methods or for different patients often contain different sets of mutation labels. Here, we generalize the Robinson - Foulds distance into a set of distance metrics called Bourque distances for comparing mutation trees. A connection between the Robinson - Foulds distance and the nearest neighbor interchange distance is also presented.

Subject Classification

ACM Subject Classification
  • Applied computing → Bioinformatics
Keywords
  • mutation trees
  • clonal trees
  • tree distance
  • phylogenetic trees
  • tree metric
  • Robinson - Foulds distance
  • Bourque distance

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