Static Analysis of a Model of the LDL Degradation Pathway

Authors Henrik Pilegaard, Hanne Riis-Nielson, Flemming Nielson

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Henrik Pilegaard
Hanne Riis-Nielson
Flemming Nielson

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Henrik Pilegaard, Hanne Riis-Nielson, and Flemming Nielson. Static Analysis of a Model of the LDL Degradation Pathway. In Simulation and Verification of Dynamic Systems. Dagstuhl Seminar Proceedings, Volume 6161, pp. 1-13, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2006)


BioAmbients is a derivative of mobile ambients that has shown promise of describing interesting features of the behaviour of biological systems. As for other ambient calculi static program analysis can be used to compute safe approximations of the behaviour of system models. We use these tools to model and analyse the production of cholesterol in living cells and show that we are able to pinpoint the difference in behaviour between models of healthy systems and models of mutated systems giving rise to known diseases.
  • Static analysis
  • Systems Biology
  • BioAmbients
  • LDL Degradation Pathway


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