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URN: urn:nbn:de:0030-drops-27419
URL: http://drops.dagstuhl.de/opus/volltexte/2010/2741/
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Comin, Matteo ; Verzotto, Davide

Remote Homology Detection of Protein Sequences

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Abstract

The classification of protein sequences using string kernels provides valuable insights for protein function prediction. Almost all string kernels are based on patterns that are not independent, and therefore the associated scores are obtained using a set of redundant features. In this talk we will discuss how a class of patterns, called Irredundant, is specifically designed to address this issue. Loosely speaking the set of Irredundant patterns is the smallest class of independent patterns that can describe all patterns in a string. We present a classification method based on the statistics of these patterns, named Irredundant Class. Results on benchmark data show that Irredundant Class outperforms most of the string kernel methods previously proposed, and it achieves results as good as the current state-of-the-art methods with a fewer number of patterns. Unfortunately we show that the information carried by the irredundant patterns can not be easily interpreted, thus alternative notions are needed.

BibTeX - Entry

@InProceedings{comin_et_al:DSP:2010:2741,
  author =	{Matteo Comin and Davide Verzotto},
  title =	{Remote Homology Detection of Protein Sequences},
  booktitle =	{Structure Discovery in Biology: Motifs, Networks & Phylogenies},
  year =	{2010},
  editor =	{Alberto Apostolico and Andreas Dress and Laxmi Parida},
  number =	{10231},
  series =	{Dagstuhl Seminar Proceedings},
  ISSN =	{1862-4405},
  publisher =	{Schloss Dagstuhl - Leibniz-Zentrum fuer Informatik, Germany},
  address =	{Dagstuhl, Germany},
  URL =		{http://drops.dagstuhl.de/opus/volltexte/2010/2741},
  annote =	{Keywords: Classification of protein sequences, irredundant patterns}
}

Keywords: Classification of protein sequences, irredundant patterns
Seminar: 10231 - Structure Discovery in Biology: Motifs, Networks & Phylogenies
Issue Date: 2010
Date of publication: 24.08.2010


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