Systems biology approaches for prioritizing therapeutic gene targets

Schuchhardt, Johannes

doi:10.4230/DagSemProc.08131.16

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Systems biology approaches for prioritizing therapeutic gene targets

Author Johannes Schuchhardt

Part of: Volume: Dagstuhl Seminar Proceedings, Volume 8131
Part of: Series: Dagstuhl Seminar Proceedings (DagSemProc)
License: Creative Commons Attribution 4.0 International license
Publication Date: 2008-06-03

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Document Identifiers

DOI: 10.4230/DagSemProc.08131.16
URN: urn:nbn:de:0030-drops-15053

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Keywords

Rational therapy
predictive modelling
data integration
ontologies
pathway databases

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Abstract

Rational approaches to therapy of complex diseases may be improved by predictive
modelling of underlying disease mechanisms. Formulating and implementing such
models requires the integration of heterogeneous information from different sources
and usually entails considerable effort. We need new concepts and resources making
knowledge on causal regulatory interactions of genes and physiological states in a
disease context available. Dedicated ontologies and text mining methods can be of
great use for guiding and supporting the process of model construction and model
evaluation.

Cite As Get BibTex

Johannes Schuchhardt. Systems biology approaches for prioritizing therapeutic gene targets. In Ontologies and Text Mining for Life Sciences : Current Status and Future Perspectives. Dagstuhl Seminar Proceedings, Volume 8131, p. 1, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2008) https://doi.org/10.4230/DagSemProc.08131.16

Author Details

Johannes Schuchhardt

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