LIPIcs.ICLP.2010.2.pdf
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A Logical Paradigm for Systems Biology (Invited Talk)
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Technical Communications of the 26th International Conference on Logic Programming (ICLP 2010)
Series: Leibniz International Proceedings in Informatics (LIPIcs)
Conference: International Conference on Logic Programming (ICLP) - License:
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported license
- Publication Date: 2010-06-25
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François Fages. A Logical Paradigm for Systems Biology (Invited Talk). In Technical Communications of the 26th International Conference on Logic Programming. Leibniz International Proceedings in Informatics (LIPIcs), Volume 7, pp. 2-3, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2010)
https://doi.org/10.4230/LIPIcs.ICLP.2010.2
Abstract
Biologists use diagrams to represent complex systems of interaction between molecular species. These graphical notations encompass two types of information: interactions (e.g. protein complexation, modification, binding to a gene, etc.) and regulations (of an interaction or a transcription). Based on these structures, mathematical models can be developed by equipping such molecular interaction networks with kinetic expressions leading to quantitative models of mainly two kinds: ordinary differential equations for a continuous interpretation of the kinetics and continuous-time Markov chains for a stochastic interpretation of the kinetics. Since 2002, we investigate the transposition of programming concepts and tools to the analysis of living processes at the cellular level.
Subject Classification
Keywords
- temporal logic
- model-checking
- systems biology
- hybrid systems
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