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DOI: 10.4230/DFU.Vol2.SciViz.2011.103

Simulation and Visualization of Medical Application to the Inner Ear of the Guinea Pig to Reduce Animal Experiments

Authors: Martin Hering-Bertram, Norbert Siedow, Oliver Tse, Stefan K. Plontke, and Ruth Gill

Published in: Dagstuhl Follow-Ups, Volume 2, Scientific Visualization: Interactions, Features, Metaphors (2011)

Abstract

We present a novel approach to simulate drug application to the inner ear of the guinea pig with the goal to reduce animal experiments and to increase the accuracy of measurements. The framework is based on a tetrahedral grid representing the individual compartments of the cochlea, associated with a finite element model used to simulate medical diffusion and clearance. In a first simulation scenario, we were able to compute transfer coefficients between the inner compartments of the ear, validating experiments from the literature, and to prove the existence of clearance at the inner scala tympani. In a second scenario, the cochlea was unwound to obtain a one-dimensional model for efficient simulation-based transfer coefficient identification. These coefficients are useful to predict the impact of novel medication application systems.

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Martin Hering-Bertram, Norbert Siedow, Oliver Tse, Stefan K. Plontke, and Ruth Gill. Simulation and Visualization of Medical Application to the Inner Ear of the Guinea Pig to Reduce Animal Experiments. In Scientific Visualization: Interactions, Features, Metaphors. Dagstuhl Follow-Ups, Volume 2, pp. 103-117, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2011)

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@InCollection{heringbertram_et_al:DFU.Vol2.SciViz.2011.103,
  author =	{Hering-Bertram, Martin and Siedow, Norbert and Tse, Oliver and Plontke, Stefan K. and Gill, Ruth},
  title =	{{Simulation and Visualization of Medical Application to the Inner Ear of the Guinea Pig to Reduce Animal Experiments}},
  booktitle =	{Scientific Visualization: Interactions, Features, Metaphors},
  pages =	{103--117},
  series =	{Dagstuhl Follow-Ups},
  ISBN =	{978-3-939897-26-2},
  ISSN =	{1868-8977},
  year =	{2011},
  volume =	{2},
  editor =	{Hagen, Hans},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/DFU.Vol2.SciViz.2011.103},
  URN =		{urn:nbn:de:0030-drops-32895},
  doi =		{10.4230/DFU.Vol2.SciViz.2011.103},
  annote =	{Keywords: Cochlea, Perilymph, Spiral Ligament, Round Window Application, Modiolar Communication Routes, Numerical Simulation, Parameter Identification}
}

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Simulation and Visualization of Medical Application to the Inner Ear of the Guinea Pig to Reduce Animal Experiments

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