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The Artemis programme seeks to develop and test concepts, hardware and approaches to support long term habitation of the Lunar surface, and future missions to Mars. In preparation for the Artemis missions determination of tasks to be performed, the functional requirements of such tasks and as mission duration extends whether physiological deconditioning becomes functionally significant, compromising the crew member’s ability to perform critical tasks on the surface, and/or upon return to earth [MoLo-LUNA – leveraging the Molo programme (and several other activities) - could become a key supporting activity for LUNA incl. validation of the Puppeteer offloading system itself via creation of a complementary MoLo-LUNA-LAB. Furthermore, the MoLo-LUNA programme could become a key facilitator of simulator suit instrumentation/definition, broader astronaut training activities and mission architecture development – including Artemis mission simulations. By employing a Puppeteer system external to the LUNA chamber hall it will optimise utilisation and cost-effectiveness of LUNA, and as such represents a critical service to future LUNA stakeholders. Furthermore, MoLo-LUNA would generate a unique data set that can be leveraged to predict de-conditioning on the Lunar surface - and thereby optimise functionality, and minimise mission risk – including informing the need for, and prescription of exercise countermeasures on the Lunar Surface and in transit. Thus, MoLo-LUNA offers a unique opportunity to place LUNA, and ESA as a key ongoing provider of evidence to define, optimise and support crew Artemis surface missions.