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Blockchain validators can reduce block processing time by exploiting multi-core CPUs, but deterministic execution must preserve a given total order while respecting transaction conflicts and per-block runtime limits. This paper systematically examines how validators can exploit multi-core parallelism during both block construction and execution without violating blockchain semantics. We formalize two validator-side optimization problems: (i) executing an already ordered block on p cores to minimize makespan while ensuring equivalence to sequential execution; and (ii) selecting and scheduling a subset of mempool transactions under a runtime limit B to maximize validator reward. For both, we develop exact Mixed-Integer Linear Programming (MILP) formulations that capture conflict, order, and capacity constraints, and propose fast deterministic heuristics that scale to realistic workloads. Using Ethereum mainnet traces and including a Solana-inspired declared-access baseline (Sol) for ordered-block scheduling and a simple reward-greedy baseline (RG) for block construction, we empirically quantify the trade-offs between optimality and runtime. MILPs quickly become intractable as heterogeneity or core count increases, whereas our heuristics run in milliseconds and achieve near-optimal quality. For ordered-block execution, heuristic makespans are typically within a few percent of the MILP solutions (and can even surpass the MILP incumbent when the solver times out), yielding up to 1.5 speedup with p = 2 and 2.3 speedup with p = 8 over sequential execution, despite tight ordering constraints. For block construction, the heuristic achieves 99-100% of the MILP optimum reward on homogeneous workloads, and 74-100% of an LP-relaxation upper bound on heterogeneous workloads, where exact optimization often times out. The resulting block-construction throughput scales close to linearly with p, reaching up to 7.9 speedup with p = 8 in our experiments. These results demonstrate that lightweight, conflict-aware scheduling and selection can unlock substantial parallelism in blockchain validation, bridging the gap between sequential execution and the true potential of multi-core hardware.