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Documents authored by Tomai, Evan

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DOI: 10.4230/LIPIcs.SWAT.2026.3
Reachability with Restricted Reactions in Inhibitory Chemical Reaction Networks

Authors: Divya Bajaj, Bin Fu, Ryan Knobel, Austin Luchsinger, Aiden Massie, Pablo Santos, Ramiro Santos, Robert Schweller, Evan Tomai, and Tim Wylie

Published in: LIPIcs, Volume 370, 20th Scandinavian Symposium on Algorithm Theory (SWAT 2026)

Abstract
Chemical Reaction Networks (CRNs) are a well-established model of distributed computing characterized by quantities of molecular species that can transform or change through applications of reactions. A fundamental problem in CRNs is the reachability problem, which asks if an initial configuration of species can transition to a target configuration through an applicable sequence of reactions. It is well-known that the reachability problem in general CRNs was recently proven to be Ackermann-complete. However, if the CRN’s reactions are restricted in both power, such as only deleting species (deletion-only rules) or consuming and producing an equal number of species (volume-preserving rules), and size (unimolecular or bimolecular rules), then reachability falls below Ackermann-completeness, and is even solvable in polynomial time for deletion-only systems. In this paper, we investigate reachability under this set of restricted unimolecular and bimolecular reactions, but in the Priority-Inhibitory CRN and Inhibitory CRN models. These models extend a traditional CRN by allowing some reactions to be inhibited from firing in a configuration if certain species are present; the exact inhibition behavior varies between the models. We first show that reachability with Priority iCRNs mostly remains in P for deletion-only systems, but becomes NP-complete for one case. We then show that reachability with deletion-only reactions for iCRNs is mostly NP-complete, and PSPACE-complete even for (1,1)-size (general) reactions. We also provide FPT algorithms for solving most of the reachability problems for the iCRN model. Finally, we show reachability for CRNs with states is already NP-hard for the simplest deletion-only systems, and is PSPACE-complete even for (general) (1,1)-size reactions.
Cite as

Divya Bajaj, Bin Fu, Ryan Knobel, Austin Luchsinger, Aiden Massie, Pablo Santos, Ramiro Santos, Robert Schweller, Evan Tomai, and Tim Wylie. Reachability with Restricted Reactions in Inhibitory Chemical Reaction Networks. In 20th Scandinavian Symposium on Algorithm Theory (SWAT 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 370, pp. 3:1-3:18, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{bajaj_et_al:LIPIcs.SWAT.2026.3,
  author =	{Bajaj, Divya and Fu, Bin and Knobel, Ryan and Luchsinger, Austin and Massie, Aiden and Santos, Pablo and Santos, Ramiro and Schweller, Robert and Tomai, Evan and Wylie, Tim},
  title =	{{Reachability with Restricted Reactions in Inhibitory Chemical Reaction Networks}},
  booktitle =	{20th Scandinavian Symposium on Algorithm Theory (SWAT 2026)},
  pages =	{3:1--3:18},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-421-5},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{370},
  editor =	{Fraigniaud, Pierre},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.SWAT.2026.3},
  URN =		{urn:nbn:de:0030-drops-260399},
  doi =		{10.4230/LIPIcs.SWAT.2026.3},
  annote =	{Keywords: Chemical Reaction Networks, Vector Addition Systems, Petri-nets, Reachability, Inhibitors, Void Reactions}
}
Document
DOI: 10.4230/LIPIcs.ITCS.2026.14
General Computation Using Slidable Tiles with Deterministic Global Forces

Authors: Alberto Avila-Jimenez, David Barreda, Sarah-Laurie Evans, Austin Luchsinger, Aiden Massie, Robert Schweller, Evan Tomai, and Tim Wylie

Published in: LIPIcs, Volume 362, 17th Innovations in Theoretical Computer Science Conference (ITCS 2026)

Abstract
We study the computational power of the Full-Tilt model of motion planning, where slidable polyominos are moved maximally around a board by way of a sequence of directional "tilts." We focus on the deterministic scenario in which the tilts constitute a repeated clockwise rotation. We show that general-purpose computation is possible within this framework by providing a direct and efficient simulation of space-bounded Turing machines in which one computational step of the machine is simulated per O(1) rotations. We further show that the initial tape of the machine can be programmed by an initial tilt-sequence preceding the rotations. This result immediately implies new PSPACE-completeness results for the well-studied problems of occupancy (deciding if a given board location can be occupied by a tile), vacancy (deciding if a location can be emptied), relocation (deciding if a tile can be moved from one location to another), and reconfiguration (can a given board configuration be reconfigured into a second given configuration) that hold even for deterministically repeating tilt cycles such as rotations. All of our PSPACE-completeness results hold even when there is only a single domino in the system beyond singleton tiles. Following, we show that these results work in the Single-Step tilt model for larger constant cycles. We then investigate computational efficiency by showing a modification to implement a two-tape Turing machine in the Full-Tilt model and Systolic Arrays in the Single-Step model. Finally, we show a cyclic implementation for tilt-efficient Threshold Circuits.
Cite as

Alberto Avila-Jimenez, David Barreda, Sarah-Laurie Evans, Austin Luchsinger, Aiden Massie, Robert Schweller, Evan Tomai, and Tim Wylie. General Computation Using Slidable Tiles with Deterministic Global Forces. In 17th Innovations in Theoretical Computer Science Conference (ITCS 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 362, pp. 14:1-14:25, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{avilajimenez_et_al:LIPIcs.ITCS.2026.14,
  author =	{Avila-Jimenez, Alberto and Barreda, David and Evans, Sarah-Laurie and Luchsinger, Austin and Massie, Aiden and Schweller, Robert and Tomai, Evan and Wylie, Tim},
  title =	{{General Computation Using Slidable Tiles with Deterministic Global Forces}},
  booktitle =	{17th Innovations in Theoretical Computer Science Conference (ITCS 2026)},
  pages =	{14:1--14:25},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-410-9},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{362},
  editor =	{Saraf, Shubhangi},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ITCS.2026.14},
  URN =		{urn:nbn:de:0030-drops-253019},
  doi =		{10.4230/LIPIcs.ITCS.2026.14},
  annote =	{Keywords: motion planning, global control, external forces, deterministic computation, occupancy, vacancy}
}
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