2 Search Results for "Oliboni, Barbara"

Document
DOI: 10.4230/LIPIcs.TIME.2025.13
Temporal Ensemble Logic for Integrative Representation of the Entirety of Clinical Trials

Authors: Xiaojin Li, Yan Huang, Rashmie Abeysinghe, Zenan Sun, Hongyu Chen, Pengze Li, Xing He, Shiqiang Tao, Cui Tao, Jiang Bian, Licong Cui, and Guo-Qiang Zhang

Published in: LIPIcs, Volume 355, 32nd International Symposium on Temporal Representation and Reasoning (TIME 2025)

Abstract
Clinical trials are typically specified with protocols that define eligibility criteria, treatment regimens, follow-up schedules, and outcome assessments. Temporality is a hallmark of all clinical trials, reflected within and across trial components, with complex dependencies unfolding across multiple time points. Despite their importance, clinical trial protocols are described in free-text format, limiting their semantic precision and the ability to support automated reasoning, leverage data across studies and sites, or simulate trial execution under varying assumptions using Real-World Data. This paper introduces a formalized representation of clinical trials using Temporal Ensemble Logic (TEL). TEL incorporates metricized modal operators, such as "always until t" (□_t) and "possibly until t" (◇_t), where t is a time-length parameter, to offer a logical framework for capturing phenotypes in biomedicine. TEL is more expressive in syntax than classical linear temporal logic (LTL) while maintaining the simplicity of semantic structures. The attributes of TEL are exploited in this paper to formally represent not only individual clinical trial components, but also the timing and sequential dependencies of these components as a whole. Modeling strategies and demonstration case studies are provided to show that TEL can represent the entirety of clinical trials, whereby providing a formal logical framework that can be used to represent the intricate temporal dependencies in trial structure specification. Since clinical trials are a cornerstone of evidence-based medicine, serving as the scientific basis for evaluating the safety, efficacy, and comparative effectiveness of therapeutic interventions, results reported here can serve as a stepping stone that leads to scalable, consistent, and reproducible representation and simulation of clinical trials across all disease domains.
Cite as

Xiaojin Li, Yan Huang, Rashmie Abeysinghe, Zenan Sun, Hongyu Chen, Pengze Li, Xing He, Shiqiang Tao, Cui Tao, Jiang Bian, Licong Cui, and Guo-Qiang Zhang. Temporal Ensemble Logic for Integrative Representation of the Entirety of Clinical Trials. In 32nd International Symposium on Temporal Representation and Reasoning (TIME 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 355, pp. 13:1-13:16, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

Copy BibTex To Clipboard

@InProceedings{li_et_al:LIPIcs.TIME.2025.13,
  author =	{Li, Xiaojin and Huang, Yan and Abeysinghe, Rashmie and Sun, Zenan and Chen, Hongyu and Li, Pengze and He, Xing and Tao, Shiqiang and Tao, Cui and Bian, Jiang and Cui, Licong and Zhang, Guo-Qiang},
  title =	{{Temporal Ensemble Logic for Integrative Representation of the Entirety of Clinical Trials}},
  booktitle =	{32nd International Symposium on Temporal Representation and Reasoning (TIME 2025)},
  pages =	{13:1--13:16},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-401-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{355},
  editor =	{Vidal, Thierry and Wa{\l}\k{e}ga, Przemys{\l}aw Andrzej},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.TIME.2025.13},
  URN =		{urn:nbn:de:0030-drops-244595},
  doi =		{10.4230/LIPIcs.TIME.2025.13},
  annote =	{Keywords: Temporal ensemble logic, Clinical trials, Logic-based modeling}
}
Document
DOI: 10.4230/LIPIcs.TIME.2019.5
Customizing BPMN Diagrams Using Timelines

Authors: Carlo Combi, Barbara Oliboni, and Pietro Sala

Published in: LIPIcs, Volume 147, 26th International Symposium on Temporal Representation and Reasoning (TIME 2019)

Abstract
BPMN (Business Process Model and Notation) is widely used standard modeling technique for representing Business Processes by using diagrams, but lacks in some aspects. Representing execution-dependent and time-dependent decisions in BPMN Diagrams may be a daunting challenge [Carlo Combi et al., 2017]. In many cases such constraints are omitted in order to preserve the simplicity and the readability of the process model. However, for purposes such as compliance checking, process mining, and verification, formalizing such constraints could be very useful. In this paper, we propose a novel approach for annotating BPMN Diagrams with Temporal Synchronization Rules borrowed from the timeline-based planning field. We discuss the expressivity of the proposed approach and show that it is able to capture a lot of complex temporally-related constraints without affecting the structure of BPMN diagrams. Finally, we provide a mapping from annotated BPMN diagrams to timeline-based planning problems that allows one to take advantage of the last twenty years of theoretical and practical developments in the field.
Cite as

Carlo Combi, Barbara Oliboni, and Pietro Sala. Customizing BPMN Diagrams Using Timelines. In 26th International Symposium on Temporal Representation and Reasoning (TIME 2019). Leibniz International Proceedings in Informatics (LIPIcs), Volume 147, pp. 5:1-5:17, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2019)

Copy BibTex To Clipboard

@InProceedings{combi_et_al:LIPIcs.TIME.2019.5,
  author =	{Combi, Carlo and Oliboni, Barbara and Sala, Pietro},
  title =	{{Customizing BPMN Diagrams Using Timelines}},
  booktitle =	{26th International Symposium on Temporal Representation and Reasoning (TIME 2019)},
  pages =	{5:1--5:17},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-127-6},
  ISSN =	{1868-8969},
  year =	{2019},
  volume =	{147},
  editor =	{Gamper, Johann and Pinchinat, Sophie and Sciavicco, Guido},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.TIME.2019.5},
  URN =		{urn:nbn:de:0030-drops-113630},
  doi =		{10.4230/LIPIcs.TIME.2019.5},
  annote =	{Keywords: Business Processes, BPMN, Timelines, Temporal Constraints}
}
  • Refine by Type
  • 2 Document/PDF
  • 1 Document/HTML

  • Refine by Publication Year
  • 1 2025
  • 1 2019

  • Refine by Author
  • 1 Abeysinghe, Rashmie
  • 1 Bian, Jiang
  • 1 Chen, Hongyu
  • 1 Combi, Carlo
  • 1 Cui, Licong
  • Show More...

  • Refine by Series/Journal
  • 2 LIPIcs

  • Refine by Classification
  • 1 Applied computing
  • 1 Applied computing → Business process modeling
  • 1 Theory of computation → Theory and algorithms for application domains

  • Refine by Keyword
  • 1 BPMN
  • 1 Business Processes
  • 1 Clinical trials
  • 1 Logic-based modeling
  • 1 Temporal Constraints
  • Show More...

Any Issues?
X

Feedback on the Current Page

CAPTCHA

Thanks for your feedback!

Feedback submitted to Dagstuhl Publishing

Could not send message

Please try again later or send an E-mail
© 2023-2025 Schloss Dagstuhl – LZI GmbH About DROPS Imprint Privacy Contact