Analyzing various models of Circadian Clock and Cell Cycle coupling

Csikász-Nagy, Attila; Faure, Adrien; Larcher, Roberto; Lecca, Paola; Mura, Ivan; Jordan, Ferenc; Palmisano, Alida; Romanel, Alessandro; Sedwards, Sean; Siebert, Heike; Soliman, Sylvain; Thieffry, Denis; Zámborszky, Judit; Mazza, Tommaso; Ballarini, Paolo

doi:10.4230/DagSemProc.09091.3

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Analyzing various models of Circadian Clock and Cell Cycle coupling

Authors Attila Csikász-Nagy, Adrien Faure, Roberto Larcher, Paola Lecca, Ivan Mura, Ferenc Jordan, Alida Palmisano, Alessandro Romanel, Sean Sedwards, Heike Siebert, Sylvain Soliman, Denis Thieffry, Judit Zámborszky, Tommaso Mazza, Paolo Ballarini

Part of: Volume: Dagstuhl Seminar Proceedings, Volume 9091
Part of: Series: Dagstuhl Seminar Proceedings (DagSemProc)
License: Creative Commons Attribution 4.0 International license
Publication Date: 2009-05-05

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DOI: 10.4230/DagSemProc.09091.3
URN: urn:nbn:de:0030-drops-19944

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Keywords

Cell cycle
circadian clock
computational modelling

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Abstract

The daily rhythm can influence the proliferation rate of many cell types.
In the mammalian system the transcription of the cell cycle regulatory
protein Wee1 is controlled by the circadian clock. Zamborszky et  al.
(2007) present a computational model coupling the cell cycle and circadian
rhythm, showing that this coupling can lead to multimodal cell cycle time 
distributions. Biological data points to additional couplings, including a
link  back from the cell cycle to the circadian clock. Proper modelling of
this coupling requires a more  detailed description of both parts of the
model. Hence, we aim at further  extending and analysing earlier models
using a combination of modelling  techniques and computer software,
including CoSBI lab, BIOCHAM, and GINsim.

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Attila Csikász-Nagy, Adrien Faure, Roberto Larcher, Paola Lecca, Ivan Mura, Ferenc Jordan, Alida Palmisano, Alessandro Romanel, Sean Sedwards, Heike Siebert, Sylvain Soliman, Denis Thieffry, Judit Zámborszky, Tommaso Mazza, and Paolo Ballarini. Analyzing various models of Circadian Clock and Cell Cycle coupling. In Formal Methods in Molecular Biology. Dagstuhl Seminar Proceedings, Volume 9091, pp. 1-6, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2009) https://doi.org/10.4230/DagSemProc.09091.3

Author Details

Attila Csikász-Nagy

Adrien Faure

Roberto Larcher

Paola Lecca

Ivan Mura

Ferenc Jordan

Alida Palmisano

Alessandro Romanel

Sean Sedwards

Heike Siebert

Sylvain Soliman

Denis Thieffry

Judit Zámborszky

Tommaso Mazza

Paolo Ballarini

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