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Analyzing various models of Circadian Clock and Cell Cycle coupling
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Dagstuhl Seminar Proceedings, Volume 9091
Series: Dagstuhl Seminar Proceedings (DagSemProc) - License:
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- Publication Date: 2009-05-05
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Attila Csikász-Nagy, Adrien Faure, Roberto Larcher, Paola Lecca, Ivan Mura, Ferenc Jordan, Alida Palmisano, Alessandro Romanel, Sean Sedwards, Heike Siebert, Sylvain Soliman, Denis Thieffry, Judit Zámborszky, Tommaso Mazza, and Paolo Ballarini. Analyzing various models of Circadian Clock and Cell Cycle coupling. In Formal Methods in Molecular Biology. Dagstuhl Seminar Proceedings, Volume 9091, pp. 1-6, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2009)
https://doi.org/10.4230/DagSemProc.09091.3
https://doi.org/10.4230/DagSemProc.09091.3
Abstract
The daily rhythm can influence the proliferation rate of many cell types.
In the mammalian system the transcription of the cell cycle regulatory
protein Wee1 is controlled by the circadian clock. Zamborszky et al.
(2007) present a computational model coupling the cell cycle and circadian
rhythm, showing that this coupling can lead to multimodal cell cycle time
distributions. Biological data points to additional couplings, including a
link back from the cell cycle to the circadian clock. Proper modelling of
this coupling requires a more detailed description of both parts of the
model. Hence, we aim at further extending and analysing earlier models
using a combination of modelling techniques and computer software,
including CoSBI lab, BIOCHAM, and GINsim.
Keywords
- Cell cycle
- circadian clock
- computational modelling
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