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URN: urn:nbn:de:0030-drops-19944
URL: http://drops.dagstuhl.de/opus/volltexte/2009/1994/

Csikász-Nagy, Attila ; Faure, Adrien ; Larcher, Roberto ; Lecca, Paola ; Mura, Ivan ; Jordan, Ferenc ; Palmisano, Alida ; Romanel, Alessandro ; Sedwards, Sean ; Siebert, Heike ; Soliman, Sylvain ; Thieffry, Denis ; Zámborszky, Judit ; Mazza, Tommaso ; Ballarini, Paolo

Analyzing various models of Circadian Clock and Cell Cycle coupling

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Abstract

The daily rhythm can influence the proliferation rate of many cell types. In the mammalian system the transcription of the cell cycle regulatory protein Wee1 is controlled by the circadian clock. Zamborszky et al. (2007) present a computational model coupling the cell cycle and circadian rhythm, showing that this coupling can lead to multimodal cell cycle time distributions. Biological data points to additional couplings, including a link back from the cell cycle to the circadian clock. Proper modelling of this coupling requires a more detailed description of both parts of the model. Hence, we aim at further extending and analysing earlier models using a combination of modelling techniques and computer software, including CoSBI lab, BIOCHAM, and GINsim.

BibTeX - Entry

@InProceedings{csiksznagy_et_al:DSP:2009:1994,
  author =	{Attila Csik{\'a}sz-Nagy and Adrien Faure and Roberto Larcher and Paola Lecca and Ivan Mura and Ferenc Jordan and Alida Palmisano and Alessandro Romanel and Sean Sedwards and Heike Siebert and Sylvain Soliman and Denis Thieffry and Judit Z{\'a}mborszky and Tommaso Mazza and Paolo Ballarini},
  title =	{Analyzing various models of Circadian Clock and Cell Cycle coupling},
  booktitle =	{Formal Methods in Molecular Biology},
  year =	{2009},
  editor =	{Rainer Breitling and David Roger Gilbert and Monika Heiner and Corrado Priami},
  number =	{09091},
  series =	{Dagstuhl Seminar Proceedings},
  ISSN =	{1862-4405},
  publisher =	{Schloss Dagstuhl - Leibniz-Zentrum fuer Informatik, Germany},
  address =	{Dagstuhl, Germany},
  URL =		{http://drops.dagstuhl.de/opus/volltexte/2009/1994},
  annote =	{Keywords: Cell cycle, circadian clock, computational modelling}
}

Keywords: Cell cycle, circadian clock, computational modelling
Seminar: 09091 - Formal Methods in Molecular Biology
Issue date: 2009
Date of publication: 05.05.2009


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