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A Rearrangement Distance for Fully-Labelled Trees

Authors Giulia Bernardini, Paola Bonizzoni, Gianluca Della Vedova, Murray Patterson

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Author Details

Giulia Bernardini
  • DISCo, Università degli Studi Milano - Bicocca, Italy
Paola Bonizzoni
  • DISCo, Università degli Studi Milano - Bicocca, Italy
Gianluca Della Vedova
  • DISCo, Università degli Studi Milano - Bicocca, Italy
Murray Patterson
  • DISCo, Università degli Studi Milano - Bicocca, Italy

Acknowledgements

The authors wish to thank Mauricio Soto Gomez for the inspiring discussions.

Cite AsGet BibTex

Giulia Bernardini, Paola Bonizzoni, Gianluca Della Vedova, and Murray Patterson. A Rearrangement Distance for Fully-Labelled Trees. In 30th Annual Symposium on Combinatorial Pattern Matching (CPM 2019). Leibniz International Proceedings in Informatics (LIPIcs), Volume 128, pp. 28:1-28:15, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2019)
https://doi.org/10.4230/LIPIcs.CPM.2019.28

Abstract

The problem of comparing trees representing the evolutionary histories of cancerous tumors has turned out to be crucial, since there is a variety of different methods which typically infer multiple possible trees. A departure from the widely studied setting of classical phylogenetics, where trees are leaf-labelled, tumoral trees are fully labelled, i.e., every vertex has a label. In this paper we provide a rearrangement distance measure between two fully-labelled trees. This notion originates from two operations: one which modifies the topology of the tree, the other which permutes the labels of the vertices, hence leaving the topology unaffected. While we show that the distance between two trees in terms of each such operation alone can be decided in polynomial time, the more general notion of distance when both operations are allowed is NP-hard to decide. Despite this result, we show that it is fixed-parameter tractable, and we give a 4-approximation algorithm when one of the trees is binary.

Subject Classification

ACM Subject Classification
  • Mathematics of computing → Trees
  • Mathematics of computing → Graph theory
Keywords
  • Tree rearrangement distance
  • Cancer progression
  • Approximation algorithms
  • Computational complexity

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