2 Search Results for "Er, He Yang"

Document
DOI: 10.4230/LIPIcs.SoCG.2026.78
Mapping Chemical Space: Topological Data Analysis of Chemical Latent Space with Mapper

Authors: Dhruv Meduri, Chuan-Shen Hu, Cong Shen, Kelin Xia, and Bei Wang

Published in: LIPIcs, Volume 367, 42nd International Symposium on Computational Geometry (SoCG 2026)

Abstract
The vast chemical space, encompassing virtually innumerable molecules and materials, presents both immense opportunities and significant challenges. The design and discovery of novel drugs and functional materials may be viewed as a search within this space; however, the sheer scale of potential candidates renders exhaustive exploration infeasible. To address this, we introduce Chemical Mapper, a framework that integrates topological data analysis with deep learning to enable the visual exploration and analysis of chemical latent spaces. At its core, Chemical Mapper employs mapper, a widely used tool in topological data analysis, to investigate the organizational principles of chemical latent spaces defined by molecular representations learned by geometric deep learning models. In doing so, Chemical Mapper not only highlights groups of molecular representations but also uncovers the relationships among them through linkages and branching structures. Our results show that Chemical Mapper reveals intrinsic patterns associated with molecular scaffolds, functional groups, and chemical properties, as well as the structural and functional evolutions of the molecules.
Cite as

Dhruv Meduri, Chuan-Shen Hu, Cong Shen, Kelin Xia, and Bei Wang. Mapping Chemical Space: Topological Data Analysis of Chemical Latent Space with Mapper. In 42nd International Symposium on Computational Geometry (SoCG 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 367, pp. 78:1-78:20, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{meduri_et_al:LIPIcs.SoCG.2026.78,
  author =	{Meduri, Dhruv and Hu, Chuan-Shen and Shen, Cong and Xia, Kelin and Wang, Bei},
  title =	{{Mapping Chemical Space: Topological Data Analysis of Chemical Latent Space with Mapper}},
  booktitle =	{42nd International Symposium on Computational Geometry (SoCG 2026)},
  pages =	{78:1--78:20},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-418-5},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{367},
  editor =	{Ahn, Hee-Kap and Hoffmann, Michael and Nayyeri, Amir},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.SoCG.2026.78},
  URN =		{urn:nbn:de:0030-drops-258854},
  doi =		{10.4230/LIPIcs.SoCG.2026.78},
  annote =	{Keywords: Practice of computational topology, topological data analysis, applications in chemistry, mapper algorithm, high-dimensional data analysis, chemical spaces, geometric deep learning, latent space geometry}
}
Document
DOI: 10.4230/LIPIcs.DISC.2019.1
Consensus with Max Registers

Authors: James Aspnes and He Yang Er

Published in: LIPIcs, Volume 146, 33rd International Symposium on Distributed Computing (DISC 2019)

Abstract
We consider the problem of implementing randomized wait-free consensus from max registers under the assumption of an oblivious adversary. We show that max registers solve m-valued consensus for arbitrary m in expected O(log^* n) steps per process, beating the Omega(log m/log log m) lower bound for ordinary registers when m is large and the best previously known O(log log n) upper bound when m is small. A simple max-register implementation based on double-collect snapshots translates this result into an O(n log n) expected step implementation of m-valued consensus from n single-writer registers, improving on the best previously-known bound of O(n log^2 n) for single-writer registers.
Cite as

James Aspnes and He Yang Er. Consensus with Max Registers. In 33rd International Symposium on Distributed Computing (DISC 2019). Leibniz International Proceedings in Informatics (LIPIcs), Volume 146, pp. 1:1-1:9, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2019)

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@InProceedings{aspnes_et_al:LIPIcs.DISC.2019.1,
  author =	{Aspnes, James and Er, He Yang},
  title =	{{Consensus with Max Registers}},
  booktitle =	{33rd International Symposium on Distributed Computing (DISC 2019)},
  pages =	{1:1--1:9},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-126-9},
  ISSN =	{1868-8969},
  year =	{2019},
  volume =	{146},
  editor =	{Suomela, Jukka},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.DISC.2019.1},
  URN =		{urn:nbn:de:0030-drops-113088},
  doi =		{10.4230/LIPIcs.DISC.2019.1},
  annote =	{Keywords: consensus, max register, single-writer register, oblivious adversary, shared memory}
}
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