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Documents authored by Pastva, Samuel

Document
DOI: 10.4230/LIPIcs.SAT.2026.19
SMT with Uninterpreted Functions and Monotonicity Constraints in Systems Biology

Authors: Ondřej Huvar, Martin Jonáš, and Samuel Pastva

Published in: LIPIcs, Volume 377, 29th International Conference on Theory and Applications of Satisfiability Testing (SAT 2026)

Abstract
Uninterpreted functions are a key modeling tool for systems with unknown or abstracted components. Certain domains, such as systems biology, additionally impose monotonicity constraints on these components, requiring specific inputs to have a consistently positive or negative effect on the output. In this paper, we tackle the model inference problem for biological systems by applying the theory of uninterpreted functions with monotonicity constraints. We compare the performance of naive quantified encodings of the problem and the performance of the existing approach based on eager quantifier instantiation, which is based on the fact that a finite set of quantifier-free monotonicity lemmas is sufficient to encode the monotonicity of uninterpreted functions. Additionally, we consider a lazy variant of the approach that introduces the monotonicity lemmas on demand. We evaluate the SMT-based approach to model inference using a large collection of systems biology benchmarks. The results demonstrate that the instantiation-based encodings significantly outperform quantified encodings, which typically struggle with large function arities and complex instances. As the key result, we show that our approach based on SMT with uninterpreted functions and monotonicity constraints significantly outperforms state-of-the-art domain-specific tools used in systems biology, such as the ASP-based Bonesis and the BDD-based AEON.
Cite as

Ondřej Huvar, Martin Jonáš, and Samuel Pastva. SMT with Uninterpreted Functions and Monotonicity Constraints in Systems Biology. In 29th International Conference on Theory and Applications of Satisfiability Testing (SAT 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 377, pp. 19:1-19:18, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{huvar_et_al:LIPIcs.SAT.2026.19,
  author =	{Huvar, Ond\v{r}ej and Jon\'{a}\v{s}, Martin and Pastva, Samuel},
  title =	{{SMT with Uninterpreted Functions and Monotonicity Constraints in Systems Biology}},
  booktitle =	{29th International Conference on Theory and Applications of Satisfiability Testing (SAT 2026)},
  pages =	{19:1--19:18},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-431-4},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{377},
  editor =	{Ignatiev, Alexey and Szeider, Stefan},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.SAT.2026.19},
  URN =		{urn:nbn:de:0030-drops-263251},
  doi =		{10.4230/LIPIcs.SAT.2026.19},
  annote =	{Keywords: satisfiability modulo theories, uninterpreted function, monotonicity, boolean network, logic-based modeling}
}
Document
DOI: 10.4230/LIPIcs.CP.2025.17
Scalable Counting of Minimal Trap Spaces and Fixed Points in Boolean Networks

Authors: Mohimenul Kabir, Van-Giang Trinh, Samuel Pastva, and Kuldeep S Meel

Published in: LIPIcs, Volume 340, 31st International Conference on Principles and Practice of Constraint Programming (CP 2025)

Abstract
Boolean Networks (BNs) serve as a fundamental modeling framework for capturing complex dynamical systems across various domains, including systems biology, computational logic, and artificial intelligence. A crucial property of BNs is the presence of trap spaces - subspaces of the state space that, once entered, cannot be exited. Minimal trap spaces, in particular, play a significant role in analyzing the long-term behavior of BNs, making their efficient enumeration and counting essential. The fixed points in BNs are a special case of minimal trap spaces. In this work, we formulate several meaningful counting problems related to minimal trap spaces and fixed points in BNs. These problems provide valuable insights both within BN theory (e.g., in probabilistic reasoning and dynamical analysis) and in broader application areas, including systems biology, abstract argumentation, and logic programming. To address these computational challenges, we propose novel methods based on approximate answer set counting, leveraging techniques from answer set programming. Our approach efficiently approximates the number of minimal trap spaces and the number of fixed points without requiring exhaustive enumeration, making it particularly well-suited for large-scale BNs. Our experimental evaluation on an extensive and diverse set of benchmark instances shows that our methods significantly improve the feasibility of counting minimal trap spaces and fixed points, paving the way for new applications in BN analysis and beyond.
Cite as

Mohimenul Kabir, Van-Giang Trinh, Samuel Pastva, and Kuldeep S Meel. Scalable Counting of Minimal Trap Spaces and Fixed Points in Boolean Networks. In 31st International Conference on Principles and Practice of Constraint Programming (CP 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 340, pp. 17:1-17:26, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{kabir_et_al:LIPIcs.CP.2025.17,
  author =	{Kabir, Mohimenul and Trinh, Van-Giang and Pastva, Samuel and Meel, Kuldeep S},
  title =	{{Scalable Counting of Minimal Trap Spaces and Fixed Points in Boolean Networks}},
  booktitle =	{31st International Conference on Principles and Practice of Constraint Programming (CP 2025)},
  pages =	{17:1--17:26},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-380-5},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{340},
  editor =	{de la Banda, Maria Garcia},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.CP.2025.17},
  URN =		{urn:nbn:de:0030-drops-238780},
  doi =		{10.4230/LIPIcs.CP.2025.17},
  annote =	{Keywords: Computational systems biology, Boolean network, Fixed point, Trap space, Answer set counting, Projected counting, Abstract argumentation, Logic programming}
}
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