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Modern complex systems, such as radiotherapy machines, require robust strategies for fault detection, diagnosis, and prognosis to ensure operational continuity and patient safety. While data-driven methods have gained traction, few studies address diagnostic and prognostic tasks using multimodal operational data under unsupervised or semi-supervised learning settings. This gap is particularly critical given the scarcity of labeled failure data in real-world environments. This work aims to design a unified approach for fault detection, diagnosis, and prognosis using multimodal data in the absence of complete labeling. To this end, autoencoders (AEs) are employed due to their suitability for unsupervised and self-supervised learning, flexibility in handling heterogeneous data, and ability to construct latent representations optimized for various downstream tasks. A specific implementation based on a Long Short-Term Memory β-Variational Autoencoder (LSTM-β-VAE) was developed to detect anomalies in machine logs. This framework is applied to TomoTherapy® systems - a highly complex and under-explored use case within the radiotherapy domain. Initial results demonstrate strong anomaly detection performance on both a public benchmark dataset (HDFS) and a proprietary dataset derived from real-world TomoTherapy® machine faults. Beyond methodology, the paper includes a concise literature review of multimodal learning and data-driven diagnosis and prognosis with a focus on AEs. Based on this review, key research directions are identified for the continuation of the thesis, especially the integration of explainable AI as a means to enhance diagnosis capabilities in the absence of labeled faults.