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Documents authored by Yamano, Ryosuke


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Linear-Space Subquadratic-Time String Alignment Algorithm for Arbitrary Scoring Matrices

Authors: Ryosuke Yamano and Tetsuo Shibuya

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)


Abstract
Theoretically, the fastest algorithm by Crochemore et al. for computing the alignment of two given strings of size n over a constant alphabet takes O(n²/log n) time. The algorithm uses Lempel–Ziv parsing to divide the dynamic programming matrix into blocks and utilizes the repetitive structure. It is the only previously known subquadratic-time algorithm that can handle scoring matrices of arbitrary weights. However, this algorithm takes O(n²/log n) space, and reducing the space while preserving the time complexity has been an open problem for more than 20 years. We present a solution to this issue by achieving an O(n) space algorithm that maintains O(n²/log n) time. The classical refinement by Hirschberg reduces the space complexity of the textbook O(n²) algorithm to O(n) while preserving the quadratic time. However, applying this technique to the algorithm of Crochemore et al. has been considered challenging because their method requires O(n² / log n) space even when computing only the alignment score. Our modification enables the application of Hirschberg’s refinement, allowing traceback computation in O(n) space while preserving the O(n² / log n) overall time complexity. Our algorithm can be applied to both global and local string alignment problems.

Cite as

Ryosuke Yamano and Tetsuo Shibuya. Linear-Space Subquadratic-Time String Alignment Algorithm for Arbitrary Scoring Matrices. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 21:1-21:14, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)


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@InProceedings{yamano_et_al:LIPIcs.WABI.2025.21,
  author =	{Yamano, Ryosuke and Shibuya, Tetsuo},
  title =	{{Linear-Space Subquadratic-Time String Alignment Algorithm for Arbitrary Scoring Matrices}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{21:1--21:14},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.21},
  URN =		{urn:nbn:de:0030-drops-239479},
  doi =		{10.4230/LIPIcs.WABI.2025.21},
  annote =	{Keywords: String alignment, dynamic programming, linear space algorithms}
}
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