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DOI: 10.4230/LIPIcs.WABI.2020.14

The Bourque Distances for Mutation Trees of Cancers

Authors: Katharina Jahn, Niko Beerenwinkel, and Louxin Zhang

Published in: LIPIcs, Volume 172, 20th International Workshop on Algorithms in Bioinformatics (WABI 2020)

Abstract

Mutation trees are rooted trees of arbitrary node degree in which each node is labeled with a mutation set. These trees, also referred to as clonal trees, are used in computational oncology to represent the mutational history of tumours. Classical tree metrics such as the popular Robinson - Foulds distance are of limited use for the comparison of mutation trees. One reason is that mutation trees inferred with different methods or for different patients often contain different sets of mutation labels. Here, we generalize the Robinson - Foulds distance into a set of distance metrics called Bourque distances for comparing mutation trees. A connection between the Robinson - Foulds distance and the nearest neighbor interchange distance is also presented.

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Katharina Jahn, Niko Beerenwinkel, and Louxin Zhang. The Bourque Distances for Mutation Trees of Cancers. In 20th International Workshop on Algorithms in Bioinformatics (WABI 2020). Leibniz International Proceedings in Informatics (LIPIcs), Volume 172, pp. 14:1-14:22, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2020)

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@InProceedings{jahn_et_al:LIPIcs.WABI.2020.14,
  author =	{Jahn, Katharina and Beerenwinkel, Niko and Zhang, Louxin},
  title =	{{The Bourque Distances for Mutation Trees of Cancers}},
  booktitle =	{20th International Workshop on Algorithms in Bioinformatics (WABI 2020)},
  pages =	{14:1--14:22},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-161-0},
  ISSN =	{1868-8969},
  year =	{2020},
  volume =	{172},
  editor =	{Kingsford, Carl and Pisanti, Nadia},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2020.14},
  URN =		{urn:nbn:de:0030-drops-128039},
  doi =		{10.4230/LIPIcs.WABI.2020.14},
  annote =	{Keywords: mutation trees, clonal trees, tree distance, phylogenetic trees, tree metric, Robinson - Foulds distance, Bourque distance}
}

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The Bourque Distances for Mutation Trees of Cancers

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