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As humanity prepares for long-distance space exploration, optimizing group performance, the ability of a group to achieve its goals efficiently, is critical. Astronaut crews will endure isolation, confinement, and operational stress, making group synchrony - the alignment of behaviors, emotions, and physiological states - a key factor in mission success. Synchrony influences team cohesion, performance, and resilience, necessitating effective crew management strategies. This paper proposes a framework for a real-time, unobtrusive index of group synchrony to support astronauts and mission control. Research indicates that team cohesion fluctuates in isolated environments, with reduced communication and interpersonal conflicts emerging over time. A system tracking synchrony could mitigate these issues, providing proactive support and improving remote management. Additionally, it could serve as a cognitive and physiological feedback tool for astronauts and a decision-making aid for mission control, enhancing well-being and efficiency. Our approach integrates behavioral and physiological synchrony measures to assess team cohesion and performance. We propose a multi-modal synchrony index combining movement coordination, communication patterns, and physiological signals such as heart rate, electrodermal activity, and EEG. This index will be validated across different tasks to ensure applicability across diverse mission scenarios. By developing a robust synchrony index, we address a fundamental challenge in space missions: sustaining team effectiveness under extreme conditions. Beyond space exploration, our findings could benefit high-risk, high-isolation teams in submarine crews, polar expeditions, and remote research groups. Our collaboration with the Centre National d'Etudes Spatiales, the Institut de Médecine et de Physiologie Spatiales, and the Toulouse University Hospital marks the first step, with experimental data collection starting this year. Ultimately, this research fosters more adaptive, responsive, and resilient teams for future space missions.