4 Search Results for "Bosch-Calvo, Miguel"

Document
DOI: 10.4230/LIPIcs.GD.2025.5
Constrained Flips in Plane Spanning Trees

Authors: Oswin Aichholzer, Joseph Dorfer, and Birgit Vogtenhuber

Published in: LIPIcs, Volume 357, 33rd International Symposium on Graph Drawing and Network Visualization (GD 2025)

Abstract
A flip in a plane spanning tree T is the operation of removing one edge from T and adding another edge such that the resulting structure is again a plane spanning tree. For trees on a set of points in convex position we study two classic types of constrained flips: (1) Compatible flips are flips in which the removed and inserted edge do not cross each other. We relevantly improve the previous upper bound of 2n-O(√n) on the diameter of the compatible flip graph to (5n/3)-O(1), by this matching the upper bound for unrestricted flips by Bjerkevik, Kleist, Ueckerdt, and Vogtenhuber [SODA 2025] up to an additive constant of 1. We further show that no shortest compatible flip sequence removes an edge that is already in its target position. Using this so-called happy edge property, we derive a fixed-parameter tractable algorithm to compute the shortest compatible flip sequence between two given trees. (2) Rotations are flips in which the removed and inserted edge share a common vertex. Besides showing that the happy edge property does not hold for rotations, we improve the previous upper bound of 2n-O(1) for the diameter of the rotation graph to (7n/4)-O(1).
Cite as

Oswin Aichholzer, Joseph Dorfer, and Birgit Vogtenhuber. Constrained Flips in Plane Spanning Trees. In 33rd International Symposium on Graph Drawing and Network Visualization (GD 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 357, pp. 5:1-5:18, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{aichholzer_et_al:LIPIcs.GD.2025.5,
  author =	{Aichholzer, Oswin and Dorfer, Joseph and Vogtenhuber, Birgit},
  title =	{{Constrained Flips in Plane Spanning Trees}},
  booktitle =	{33rd International Symposium on Graph Drawing and Network Visualization (GD 2025)},
  pages =	{5:1--5:18},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-403-1},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{357},
  editor =	{Dujmovi\'{c}, Vida and Montecchiani, Fabrizio},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.GD.2025.5},
  URN =		{urn:nbn:de:0030-drops-249913},
  doi =		{10.4230/LIPIcs.GD.2025.5},
  annote =	{Keywords: Non-crossing spanning trees, Flip Graphs, Diameter, Complexity, Happy edges}
}
Document
DOI: 10.4230/LIPIcs.WABI.2025.11
Mutational Signature Refitting on Sparse Pan-Cancer Data

Authors: Gal Gilad, Teresa M. Przytycka, and Roded Sharan

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)

Abstract
Mutational processes shape cancer genomes, leaving characteristic marks that are termed signatures. The level of activity of each such process, or its signature exposure, provides important information on the disease, improving patient stratification and the prediction of drug response. Thus, there is growing interest in developing refitting methods that decipher those exposures. Previous work in this domain was unsupervised in nature, employing algebraic decomposition and probabilistic inference methods. Here we provide a supervised approach to the problem of signature refitting and show its superiority over current methods. Our method, SuRe, leverages a neural network model to capture correlations between signature exposures in real data. We show that SuRe outperforms previous methods on sparse mutation data from tumor type specific data sets, as well as pan-cancer data sets, with an increasing advantage as the data become sparser. We further demonstrate its utility in clinical settings.
Cite as

Gal Gilad, Teresa M. Przytycka, and Roded Sharan. Mutational Signature Refitting on Sparse Pan-Cancer Data. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 11:1-11:23, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{gilad_et_al:LIPIcs.WABI.2025.11,
  author =	{Gilad, Gal and Przytycka, Teresa M. and Sharan, Roded},
  title =	{{Mutational Signature Refitting on Sparse Pan-Cancer Data}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{11:1--11:23},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.11},
  URN =		{urn:nbn:de:0030-drops-239374},
  doi =		{10.4230/LIPIcs.WABI.2025.11},
  annote =	{Keywords: mutational signatures, signature refitting, cancer genomics, genomic data analysis, somatic mutations}
}
Document
Track A: Algorithms, Complexity and Games
DOI: 10.4230/LIPIcs.ICALP.2024.5
An O(loglog n)-Approximation for Submodular Facility Location

Authors: Fateme Abbasi, Marek Adamczyk, Miguel Bosch-Calvo, Jarosław Byrka, Fabrizio Grandoni, Krzysztof Sornat, and Antoine Tinguely

Published in: LIPIcs, Volume 297, 51st International Colloquium on Automata, Languages, and Programming (ICALP 2024)

Abstract
In the Submodular Facility Location problem (SFL) we are given a collection of n clients and m facilities in a metric space. A feasible solution consists of an assignment of each client to some facility. For each client, one has to pay the distance to the associated facility. Furthermore, for each facility f to which we assign the subset of clients S^f, one has to pay the opening cost g(S^f), where g() is a monotone submodular function with g(emptyset)=0. SFL is APX-hard since it includes the classical (metric uncapacitated) Facility Location problem (with uniform facility costs) as a special case. Svitkina and Tardos [SODA'06] gave the current-best O(log n) approximation algorithm for SFL. The same authors pose the open problem whether SFL admits a constant approximation and provide such an approximation for a very restricted special case of the problem. We make some progress towards the solution of the above open problem by presenting an O(loglog n) approximation. Our approach is rather flexible and can be easily extended to generalizations and variants of SFL. In more detail, we achieve the same approximation factor for the natural generalizations of SFL where the opening cost of each facility f is of the form p_f + g(S^f) or w_f * g(S^f), where p_f, w_f >= 0 are input values. We also obtain an improved approximation algorithm for the related Universal Stochastic Facility Location problem. In this problem one is given a classical (metric) facility location instance and has to a priori assign each client to some facility. Then a subset of active clients is sampled from some given distribution, and one has to pay (a posteriori) only the connection and opening costs induced by the active clients. The expected opening cost of each facility f can be modelled with a submodular function of the set of clients assigned to f.
Cite as

Fateme Abbasi, Marek Adamczyk, Miguel Bosch-Calvo, Jarosław Byrka, Fabrizio Grandoni, Krzysztof Sornat, and Antoine Tinguely. An O(loglog n)-Approximation for Submodular Facility Location. In 51st International Colloquium on Automata, Languages, and Programming (ICALP 2024). Leibniz International Proceedings in Informatics (LIPIcs), Volume 297, pp. 5:1-5:20, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2024)

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@InProceedings{abbasi_et_al:LIPIcs.ICALP.2024.5,
  author =	{Abbasi, Fateme and Adamczyk, Marek and Bosch-Calvo, Miguel and Byrka, Jaros{\l}aw and Grandoni, Fabrizio and Sornat, Krzysztof and Tinguely, Antoine},
  title =	{{An O(loglog n)-Approximation for Submodular Facility Location}},
  booktitle =	{51st International Colloquium on Automata, Languages, and Programming (ICALP 2024)},
  pages =	{5:1--5:20},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-322-5},
  ISSN =	{1868-8969},
  year =	{2024},
  volume =	{297},
  editor =	{Bringmann, Karl and Grohe, Martin and Puppis, Gabriele and Svensson, Ola},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ICALP.2024.5},
  URN =		{urn:nbn:de:0030-drops-201488},
  doi =		{10.4230/LIPIcs.ICALP.2024.5},
  annote =	{Keywords: approximation algorithms, facility location, submodular facility location, universal stochastic facility location}
}
Document
Track A: Algorithms, Complexity and Games
DOI: 10.4230/LIPIcs.ICALP.2023.29
A 4/3 Approximation for 2-Vertex-Connectivity

Authors: Miguel Bosch-Calvo, Fabrizio Grandoni, and Afrouz Jabal Ameli

Published in: LIPIcs, Volume 261, 50th International Colloquium on Automata, Languages, and Programming (ICALP 2023)

Abstract
The 2-Vertex-Connected Spanning Subgraph problem (2VCSS) is among the most basic NP-hard (Survivable) Network Design problems: we are given an (unweighted) undirected graph G. Our goal is to find a subgraph S of G with the minimum number of edges which is 2-vertex-connected, namely S remains connected after the deletion of an arbitrary node. 2VCSS is well-studied in terms of approximation algorithms, and the current best (polynomial-time) approximation factor is 10/7 by Heeger and Vygen [SIDMA'17] (improving on earlier results by Khuller and Vishkin [STOC'92] and Garg, Vempala and Singla [SODA'93]). Here we present an improved 4/3 approximation. Our main technical ingredient is an approximation preserving reduction to a conveniently structured subset of instances which are "almost" 3-vertex-connected. The latter reduction might be helpful in future work.
Cite as

Miguel Bosch-Calvo, Fabrizio Grandoni, and Afrouz Jabal Ameli. A 4/3 Approximation for 2-Vertex-Connectivity. In 50th International Colloquium on Automata, Languages, and Programming (ICALP 2023). Leibniz International Proceedings in Informatics (LIPIcs), Volume 261, pp. 29:1-29:13, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2023)

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@InProceedings{boschcalvo_et_al:LIPIcs.ICALP.2023.29,
  author =	{Bosch-Calvo, Miguel and Grandoni, Fabrizio and Jabal Ameli, Afrouz},
  title =	{{A 4/3 Approximation for 2-Vertex-Connectivity}},
  booktitle =	{50th International Colloquium on Automata, Languages, and Programming (ICALP 2023)},
  pages =	{29:1--29:13},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-278-5},
  ISSN =	{1868-8969},
  year =	{2023},
  volume =	{261},
  editor =	{Etessami, Kousha and Feige, Uriel and Puppis, Gabriele},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ICALP.2023.29},
  URN =		{urn:nbn:de:0030-drops-180813},
  doi =		{10.4230/LIPIcs.ICALP.2023.29},
  annote =	{Keywords: Algorithm, Network Design, Vertex-Connectivity, Approximation}
}
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