7 Search Results for "White, W. Timothy J."

Document
DOI: 10.4230/DagMan.11.1.19
Conversational Agents: A Framework for Evaluation (CAFE) (Dagstuhl Perspectives Workshop 24352)

Authors: Christine Bauer, Li Chen, Nicola Ferro, Norbert Fuhr, Avishek Anand, Timo Breuer, Guglielmo Faggioli, Ophir Frieder, Hideo Joho, Jussi Karlgren, Johannes Kiesel, Bart P. Knijnenburg, Aldo Lipani, Lien Michiels, Andrea Papenmeier, Maria Soledad Pera, Mark Sanderson, Scott Sanner, Benno Stein, Johanne R. Trippas, Karin Verspoor, and Martijn C. Willemsen

Published in: Dagstuhl Manifestos, Volume 11, Issue 1 (2025)

Abstract
During the workshop, we deeply discussed what CONversational Information ACcess (CONIAC) is and its unique features, proposing a world model abstracting it, and defined the Conversational Agents Framework for Evaluation (CAFE) for the evaluation of CONIAC systems, consisting of six major components: 1) goals of the system’s stakeholders, 2) user tasks to be studied in the evaluation, 3) aspects of the users carrying out the tasks, 4) evaluation criteria to be considered, 5) evaluation methodology to be applied, and 6) measures for the quantitative criteria chosen.
Cite as

Christine Bauer, Li Chen, Nicola Ferro, Norbert Fuhr, Avishek Anand, Timo Breuer, Guglielmo Faggioli, Ophir Frieder, Hideo Joho, Jussi Karlgren, Johannes Kiesel, Bart P. Knijnenburg, Aldo Lipani, Lien Michiels, Andrea Papenmeier, Maria Soledad Pera, Mark Sanderson, Scott Sanner, Benno Stein, Johanne R. Trippas, Karin Verspoor, and Martijn C. Willemsen. Conversational Agents: A Framework for Evaluation (CAFE) (Dagstuhl Perspectives Workshop 24352). In Dagstuhl Manifestos, Volume 11, Issue 1, pp. 19-67, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@Article{bauer_et_al:DagMan.11.1.19,
  author =	{Bauer, Christine and Chen, Li and Ferro, Nicola and Fuhr, Norbert and Anand, Avishek and Breuer, Timo and Faggioli, Guglielmo and Frieder, Ophir and Joho, Hideo and Karlgren, Jussi and Kiesel, Johannes and Knijnenburg, Bart P. and Lipani, Aldo and Michiels, Lien and Papenmeier, Andrea and Pera, Maria Soledad and Sanderson, Mark and Sanner, Scott and Stein, Benno and Trippas, Johanne R. and Verspoor, Karin and Willemsen, Martijn C.},
  title =	{{Conversational Agents: A Framework for Evaluation (CAFE) (Dagstuhl Perspectives Workshop 24352)}},
  pages =	{19--67},
  journal =	{Dagstuhl Manifestos},
  ISSN =	{2193-2433},
  year =	{2025},
  volume =	{11},
  number =	{1},
  editor =	{Bauer, Christine and Chen, Li and Ferro, Nicola and Fuhr, Norbert and Anand, Avishek and Breuer, Timo and Faggioli, Guglielmo and Frieder, Ophir and Joho, Hideo and Karlgren, Jussi and Kiesel, Johannes and Knijnenburg, Bart P. and Lipani, Aldo and Michiels, Lien and Papenmeier, Andrea and Pera, Maria Soledad and Sanderson, Mark and Sanner, Scott and Stein, Benno and Trippas, Johanne R. and Verspoor, Karin and Willemsen, Martijn C.},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/DagMan.11.1.19},
  URN =		{urn:nbn:de:0030-drops-252722},
  doi =		{10.4230/DagMan.11.1.19},
  annote =	{Keywords: Conversational Agents, Evaluation, Information Access}
}
Document
Survey
DOI: 10.4230/TGDK.3.2.1
Resilience in Knowledge Graph Embeddings

Authors: Arnab Sharma, N'Dah Jean Kouagou, and Axel-Cyrille Ngonga Ngomo

Published in: TGDK, Volume 3, Issue 2 (2025). Transactions on Graph Data and Knowledge, Volume 3, Issue 2

Abstract
In recent years, knowledge graphs have gained interest and witnessed widespread applications in various domains, such as information retrieval, question-answering, recommendation systems, amongst others. Large-scale knowledge graphs to this end have demonstrated their utility in effectively representing structured knowledge. To further facilitate the application of machine learning techniques, knowledge graph embedding models have been developed. Such models can transform entities and relationships within knowledge graphs into vectors. However, these embedding models often face challenges related to noise, missing information, distribution shift, adversarial attacks, etc. This can lead to sub-optimal embeddings and incorrect inferences, thereby negatively impacting downstream applications. While the existing literature has focused so far on adversarial attacks on KGE models, the challenges related to the other critical aspects remain unexplored. In this paper, we, first of all, give a unified definition of resilience, encompassing several factors such as generalisation, in-distribution generalization, distribution adaption, and robustness. After formalizing these concepts for machine learning in general, we define them in the context of knowledge graphs. To find the gap in the existing works on resilience in the context of knowledge graphs, we perform a systematic survey, taking into account all these aspects mentioned previously. Our survey results show that most of the existing works focus on a specific aspect of resilience, namely robustness. After categorizing such works based on their respective aspects of resilience, we discuss the challenges and future research directions.
Cite as

Arnab Sharma, N'Dah Jean Kouagou, and Axel-Cyrille Ngonga Ngomo. Resilience in Knowledge Graph Embeddings. In Transactions on Graph Data and Knowledge (TGDK), Volume 3, Issue 2, pp. 1:1-1:38, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@Article{sharma_et_al:TGDK.3.2.1,
  author =	{Sharma, Arnab and Kouagou, N'Dah Jean and Ngomo, Axel-Cyrille Ngonga},
  title =	{{Resilience in Knowledge Graph Embeddings}},
  journal =	{Transactions on Graph Data and Knowledge},
  pages =	{1:1--1:38},
  ISSN =	{2942-7517},
  year =	{2025},
  volume =	{3},
  number =	{2},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/TGDK.3.2.1},
  URN =		{urn:nbn:de:0030-drops-248117},
  doi =		{10.4230/TGDK.3.2.1},
  annote =	{Keywords: Knowledge graphs, Resilience, Robustness}
}
Document
DOI: 10.4230/LIPIcs.DNA.31.4
Differentiable Programming of Indexed Chemical Reaction Networks and Reaction-Diffusion Systems

Authors: Inhoo Lee, Salvador Buse, and Erik Winfree

Published in: LIPIcs, Volume 347, 31st International Conference on DNA Computing and Molecular Programming (DNA 31) (2025)

Abstract
Many molecular systems are best understood in terms of prototypical species and reactions. The central dogma and related biochemistry are rife with examples: gene i is transcribed into RNA i, which is translated into protein i; kinase n phosphorylates substrate m; protein p dimerizes with protein q. Engineered nucleic acid systems also often have this form: oligonucleotide i hybridizes to complementary oligonucleotide j; signal strand n displaces the output of seesaw gate m; hairpin p triggers the opening of target q. When there are many variants of a small number of prototypes, it can be conceptually cleaner and computationally more efficient to represent the full system in terms of indexed species (e.g. for dimerization, M_p, D_pq) and indexed reactions (M_p + M_q → D_pq). Here, we formalize the Indexed Chemical Reaction Network (ICRN) model and describe a Python software package designed to simulate such systems in the well-mixed and reaction-diffusion settings, using a differentiable programming framework originally developed for large-scale neural network models, taking advantage of GPU acceleration when available. Notably, this framework makes it straightforward to train the models’ initial conditions and rate constants to optimize a target behavior, such as matching experimental data, performing a computation, or exhibiting spatial pattern formation. The natural map of indexed chemical reaction networks onto neural network formalisms provides a tangible yet general perspective for translating concepts and techniques from the theory and practice of neural computation into the design of biomolecular systems.
Cite as

Inhoo Lee, Salvador Buse, and Erik Winfree. Differentiable Programming of Indexed Chemical Reaction Networks and Reaction-Diffusion Systems. In 31st International Conference on DNA Computing and Molecular Programming (DNA 31). Leibniz International Proceedings in Informatics (LIPIcs), Volume 347, pp. 4:1-4:23, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{lee_et_al:LIPIcs.DNA.31.4,
  author =	{Lee, Inhoo and Buse, Salvador and Winfree, Erik},
  title =	{{Differentiable Programming of Indexed Chemical Reaction Networks and Reaction-Diffusion Systems}},
  booktitle =	{31st International Conference on DNA Computing and Molecular Programming (DNA 31)},
  pages =	{4:1--4:23},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-399-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{347},
  editor =	{Schaeffer, Josie and Zhang, Fei},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.DNA.31.4},
  URN =		{urn:nbn:de:0030-drops-238534},
  doi =		{10.4230/LIPIcs.DNA.31.4},
  annote =	{Keywords: Differentiable Programming, Chemical Reaction Networks, Reaction-Diffusion Systems}
}
Document
DOI: 10.4230/LIPIcs.WABI.2025.5
Improved Algorithms for Bi-Partition Function Computation

Authors: John D. Bridgers, Jan Hoinka, S. Cenk Sahinalp, Salem Malikic, Teresa M. Przytycka, and Funda Ergun

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)

Abstract
The evolutionary history of a tumor, inferred from single-cell sequencing data, is typically represented as a tree in which each subtree corresponds to a clade of cells seeded by a specific set of mutations. Traditional methods typically identify a single most likely tree for downstream analyses, such as detecting driver mutations, studying mutation co-occurrence patterns and identifying common evolutionary trajectories. However, the reliability of such inferred trees, particularly their topology, clade composition, and mutational placements, often remains uncertain. To quantify this uncertainty, the concept of a Bi-partition Function was recently introduced, providing a probabilistic measure of how reliably a mutation seeds a given clade of cells. The single available algorithm for estimating the Bi-partition Function relies on simplifying assumptions and uses sampling for limited exploration of the tree-space. In this paper, we introduce the first exact algorithm for computing the Bi-partition Function. Our algorithm scales linearly with the number of mutations but exhibits super-exponential complexity with respect to the number of cells. Despite this complexity, it establishes crucial ground truth values, essential for accurately benchmarking and validating approximate methods. Additionally, we present a GPU-accelerated version of the available sampling-based algorithm, significantly boosting the computational performance through large-scale parallelization, enabling more accurate Bi-partition Function estimates via deeper exploration of the tree spaces. We compare our methods on synthetic datasets, demonstrating that especially when the number of mutations sufficiently exceed the number of cells, our GPU-accelerated sampling algorithm closely approximates the exact ground truth values.
Cite as

John D. Bridgers, Jan Hoinka, S. Cenk Sahinalp, Salem Malikic, Teresa M. Przytycka, and Funda Ergun. Improved Algorithms for Bi-Partition Function Computation. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 5:1-5:18, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{bridgers_et_al:LIPIcs.WABI.2025.5,
  author =	{Bridgers, John D. and Hoinka, Jan and Sahinalp, S. Cenk and Malikic, Salem and Przytycka, Teresa M. and Ergun, Funda},
  title =	{{Improved Algorithms for Bi-Partition Function Computation}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{5:1--5:18},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.5},
  URN =		{urn:nbn:de:0030-drops-239318},
  doi =		{10.4230/LIPIcs.WABI.2025.5},
  annote =	{Keywords: Tumor Evolution, Bi-partition Function, Single-Cell Sequencing, Algorithms}
}
Document
DOI: 10.4230/LIPIcs.ECOOP.2025.12
Automatic Goal Clone Detection in Rocq

Authors: Ali Ghanbari

Published in: LIPIcs, Volume 333, 39th European Conference on Object-Oriented Programming (ECOOP 2025)

Abstract
Proof engineering in Rocq is a labor-intensive process, and as proof developments grow in size, redundancy and maintainability become challenges. One such redundancy is goal cloning, i.e., proving α-equivalent goals multiple times, leading to wasted effort and bloated proof scripts. In this paper, we introduce clone-finder, a novel technique for detecting goal clones in Rocq proofs. By leveraging the formal notion of α-equivalence for Gallina terms, clone-finder systematically identifies duplicated proof goals across large Rocq codebases. We evaluate clone-finder on 40 real-world Rocq projects from the CoqGym dataset. Our results reveal that each project contains an average of 27.73 instances of goal clone. We observed that the clones can be categorized as either exact goal duplication, generalization, or α-equivalent goals with different proofs, each signifying varying levels duplicate effort. Our findings highlight significant untapped potential for proof reuse in Rocq-based formal verification projects, paving the way for future improvements in automated proof engineering.
Cite as

Ali Ghanbari. Automatic Goal Clone Detection in Rocq. In 39th European Conference on Object-Oriented Programming (ECOOP 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 333, pp. 12:1-12:19, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{ghanbari:LIPIcs.ECOOP.2025.12,
  author =	{Ghanbari, Ali},
  title =	{{Automatic Goal Clone Detection in Rocq}},
  booktitle =	{39th European Conference on Object-Oriented Programming (ECOOP 2025)},
  pages =	{12:1--12:19},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-373-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{333},
  editor =	{Aldrich, Jonathan and Silva, Alexandra},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ECOOP.2025.12},
  URN =		{urn:nbn:de:0030-drops-233055},
  doi =		{10.4230/LIPIcs.ECOOP.2025.12},
  annote =	{Keywords: Clone Detection, Goal, Proof, Rocq, Gallina}
}
Document
Tool Paper
DOI: 10.4230/OASIcs.FMBC.2025.13
A Benchmark Framework for Byzantine Fault Tolerance Testing Algorithms (Tool Paper)

Authors: João Miguel Louro Neto and Burcu Kulahcioglu Ozkan

Published in: OASIcs, Volume 129, 6th International Workshop on Formal Methods for Blockchains (FMBC 2025)

Abstract
Recent discoveries of vulnerabilities in the design and implementation of Byzantine fault-tolerant protocols underscore the need for testing and exploration techniques to ensure their correctness. While there has been some recent effort for automated test generation for BFT protocols, there is no benchmark framework available to systematically evaluate their performance. We present ByzzBench, a benchmark framework designed to evaluate the performance of testing algorithms in detecting Byzantine fault tolerance bugs. ByzzBench is designed for a standardized implementation of BFT protocols and their execution in a controlled testing environment. It controls the nondeterminism in the concurrency, network, and process faults in the protocol execution, enabling the functionality to enforce particular execution scenarios and thereby facilitating the implementation of testing algorithms for BFT protocols.
Cite as

João Miguel Louro Neto and Burcu Kulahcioglu Ozkan. A Benchmark Framework for Byzantine Fault Tolerance Testing Algorithms (Tool Paper). In 6th International Workshop on Formal Methods for Blockchains (FMBC 2025). Open Access Series in Informatics (OASIcs), Volume 129, pp. 13:1-13:11, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{louroneto_et_al:OASIcs.FMBC.2025.13,
  author =	{Louro Neto, Jo\~{a}o Miguel and Kulahcioglu Ozkan, Burcu},
  title =	{{A Benchmark Framework for Byzantine Fault Tolerance Testing Algorithms}},
  booktitle =	{6th International Workshop on Formal Methods for Blockchains (FMBC 2025)},
  pages =	{13:1--13:11},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-371-3},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{129},
  editor =	{Marmsoler, Diego and Xu, Meng},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.FMBC.2025.13},
  URN =		{urn:nbn:de:0030-drops-230406},
  doi =		{10.4230/OASIcs.FMBC.2025.13},
  annote =	{Keywords: Byzantine Fault Tolerance, BFT Protocols, Automated Testing}
}
Document
DOI: 10.4230/LIPIcs.WABI.2018.23
Heuristic Algorithms for the Maximum Colorful Subtree Problem

Authors: Kai Dührkop, Marie A. Lataretu, W. Timothy J. White, and Sebastian Böcker

Published in: LIPIcs, Volume 113, 18th International Workshop on Algorithms in Bioinformatics (WABI 2018)

Abstract
In metabolomics, small molecules are structurally elucidated using tandem mass spectrometry (MS/MS); this computational task can be formulated as the Maximum Colorful Subtree problem, which is NP-hard. Unfortunately, data from a single metabolite requires us to solve hundreds or thousands of instances of this problem - and in a single Liquid Chromatography MS/MS run, hundreds or thousands of metabolites are measured. Here, we comprehensively evaluate the performance of several heuristic algorithms for the problem. Unfortunately, as is often the case in bioinformatics, the structure of the (chemically) true solution is not known to us; therefore we can only evaluate against the optimal solution of an instance. Evaluating the quality of a heuristic based on scores can be misleading: Even a slightly suboptimal solution can be structurally very different from the optimal solution, but it is the structure of a solution and not its score that is relevant for the downstream analysis. To this end, we propose a different evaluation setup: Given a set of candidate instances of which exactly one is known to be correct, the heuristic in question solves each instance to the best of its ability, producing a score for each instance, which is then used to rank the instances. We then evaluate whether the correct instance is ranked highly by the heuristic. We find that one particular heuristic consistently ranks the correct instance in a top position. We also find that the scores of the best heuristic solutions are very close to the optimal score; in contrast, the structure of the solutions can deviate significantly from the optimal structures. Integrating the heuristic allowed us to speed up computations in practice by a factor of 100-fold.
Cite as

Kai Dührkop, Marie A. Lataretu, W. Timothy J. White, and Sebastian Böcker. Heuristic Algorithms for the Maximum Colorful Subtree Problem. In 18th International Workshop on Algorithms in Bioinformatics (WABI 2018). Leibniz International Proceedings in Informatics (LIPIcs), Volume 113, pp. 23:1-23:14, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2018)

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@InProceedings{duhrkop_et_al:LIPIcs.WABI.2018.23,
  author =	{D\"{u}hrkop, Kai and Lataretu, Marie A. and White, W. Timothy J. and B\"{o}cker, Sebastian},
  title =	{{Heuristic Algorithms for the Maximum Colorful Subtree Problem}},
  booktitle =	{18th International Workshop on Algorithms in Bioinformatics (WABI 2018)},
  pages =	{23:1--23:14},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-082-8},
  ISSN =	{1868-8969},
  year =	{2018},
  volume =	{113},
  editor =	{Parida, Laxmi and Ukkonen, Esko},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2018.23},
  URN =		{urn:nbn:de:0030-drops-93256},
  doi =		{10.4230/LIPIcs.WABI.2018.23},
  annote =	{Keywords: Fragmentation trees, Computational mass spectrometry}
}
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