7 Search Results for "Mumey, Brendan"

Document
DOI: 10.4230/LIPIcs.ESA.2025.55
Safe Sequences via Dominators in DAGs for Path-Covering Problems

Authors: Francisco Sena, Romeo Rizzi, and Alexandru I. Tomescu

Published in: LIPIcs, Volume 351, 33rd Annual European Symposium on Algorithms (ESA 2025)

Abstract
A path-covering problem on a directed acyclic graph (DAG) requires finding a set of source-to-sink paths that cover all the nodes, all the arcs, or subsets thereof, and additionally they are optimal with respect to some function. In this paper we study safe sequences of nodes or arcs, namely sequences that appear in some path of every path cover of a DAG. We show that safe sequences admit a simple characterization via cutnodes. Moreover, we establish a connection between maximal safe sequences and leaf-to-root paths in the source- and sink-dominator trees of the DAG, which may be of independent interest in the extensive literature on dominators. With dominator trees, safe sequences admit an O(n)-size representation and a linear-time output-sensitive enumeration algorithm running in time O(m + o), where n and m are the number of nodes and arcs, respectively, and o is the total length of the maximal safe sequences. We then apply maximal safe sequences to simplify Integer Linear Programs (ILPs) for two path-covering problems, LeastSquares and MinPathError, which are at the core of RNA transcript assembly problems from bioinformatics. On various datasets, maximal safe sequences can be computed in under 0.1 seconds per graph, on average, and ILP solvers whose search space is reduced in this manner exhibit significant speed-ups. For example on graphs with a large width, average speed-ups are in the range 50-250× for MinPathError and in the range 80-350× for LeastSquares. Optimizing ILPs using safe sequences can thus become a fast building block of practical RNA transcript assembly tools, and more generally, of path-covering problems.
Cite as

Francisco Sena, Romeo Rizzi, and Alexandru I. Tomescu. Safe Sequences via Dominators in DAGs for Path-Covering Problems. In 33rd Annual European Symposium on Algorithms (ESA 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 351, pp. 55:1-55:17, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{sena_et_al:LIPIcs.ESA.2025.55,
  author =	{Sena, Francisco and Rizzi, Romeo and Tomescu, Alexandru I.},
  title =	{{Safe Sequences via Dominators in DAGs for Path-Covering Problems}},
  booktitle =	{33rd Annual European Symposium on Algorithms (ESA 2025)},
  pages =	{55:1--55:17},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-395-9},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{351},
  editor =	{Benoit, Anne and Kaplan, Haim and Wild, Sebastian and Herman, Grzegorz},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ESA.2025.55},
  URN =		{urn:nbn:de:0030-drops-245230},
  doi =		{10.4230/LIPIcs.ESA.2025.55},
  annote =	{Keywords: directed acyclic graph, path cover, dominator tree, integer linear programming, least squares, minimum path error}
}
Document
APPROX
DOI: 10.4230/LIPIcs.APPROX/RANDOM.2025.10
Improved Approximation Guarantees for Advertisement Placement

Authors: Waldo Gálvez, Roberto Oliva, and Victor Verdugo

Published in: LIPIcs, Volume 353, Approximation, Randomization, and Combinatorial Optimization. Algorithms and Techniques (APPROX/RANDOM 2025)

Abstract
The advertisement placement problem involves selecting and scheduling ads within a timeline that has capacity constraints to maximize profit. Each task is characterized by its height, width, and profit, and must be fully scheduled across multiple time slots. This problem models practical scenarios such as internet advertising and energy management, and it also generalizes classical combinatorial optimization problems like the knapsack and bin packing problems. We present a simple (2+ε)-approximation algorithm for any ε > 0, which improves upon the state-of-the-art 3+ε factor established by Freund and Naor twenty years ago. Our approach combines rounding techniques with dynamic programming and an efficient extension of list scheduling. Furthermore, we enhance this method with linear programming techniques to provide an almost optimal (1+ε)-approximation algorithm under resource augmentation, which allows for a slight increase in time slot capacities.
Cite as

Waldo Gálvez, Roberto Oliva, and Victor Verdugo. Improved Approximation Guarantees for Advertisement Placement. In Approximation, Randomization, and Combinatorial Optimization. Algorithms and Techniques (APPROX/RANDOM 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 353, pp. 10:1-10:16, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{galvez_et_al:LIPIcs.APPROX/RANDOM.2025.10,
  author =	{G\'{a}lvez, Waldo and Oliva, Roberto and Verdugo, Victor},
  title =	{{Improved Approximation Guarantees for Advertisement Placement}},
  booktitle =	{Approximation, Randomization, and Combinatorial Optimization. Algorithms and Techniques (APPROX/RANDOM 2025)},
  pages =	{10:1--10:16},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-397-3},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{353},
  editor =	{Ene, Alina and Chattopadhyay, Eshan},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.APPROX/RANDOM.2025.10},
  URN =		{urn:nbn:de:0030-drops-243762},
  doi =		{10.4230/LIPIcs.APPROX/RANDOM.2025.10},
  annote =	{Keywords: Advertisement Placement, Two-dimensional Packing, Geometric Knapsack, Resource Allocation}
}
Document
DOI: 10.4230/LIPIcs.WABI.2025.6
Fast Pseudoalignment Queries on Compressed Colored de Bruijn Graphs

Authors: Alessio Campanelli, Giulio Ermanno Pibiri, and Rob Patro

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)

Abstract
Motivation. Indexes for the colored de Bruijn graph (c-dBG) play a crucial role in computational biology by facilitating complex tasks such as read mapping and assembly. These indexes map k-mers (substrings of length k) appearing in a large collection of reference strings to the set of identifiers of the strings where they appear. These sets, colloquially referred to as color sets, tend to occupy large quantities of memory, especially for large pangenomes. Our previous work thus focused on leveraging the repetitiveness of the color sets to improve the space effectiveness of the resulting index. As a matter of fact, repetition-aware indexes can be up to one order of magnitude smaller on large pangenomes compared to indexes that do not exploit such repetitiveness. Such improved space effectiveness, on the other hand, imposes an overhead at query time when performing tasks such as pseudoalignment that require the collection and processing of multiple related color sets. Methods. In this paper, we show how to avoid this overhead. We devise novel query algorithms tailored for the specific repetition-aware representations adopted by the Fulgor index, a state-of-the-art c-dBG index, to significantly improve its pseudoalignment efficiency and without consuming additional space. Results. Our results indicate that with increasing redundancy in the pangenomes, the compression factor provided by the Fulgor index increases, while the relative query time actually reduces. For example, while the space of the Fulgor index improves by 2.5× with repetition-aware compression and its query time improves by 1.6× on a collection of 5,000 Salmonella Enterica genomes, these factors become (6.1×,2.8×) and (11.2×,3.2×) for 50,000 and 150,000 genomes respectively. For an even larger collection of 300,000 genomes, we obtained an index that is 22.3× smaller and 2.2× faster.
Cite as

Alessio Campanelli, Giulio Ermanno Pibiri, and Rob Patro. Fast Pseudoalignment Queries on Compressed Colored de Bruijn Graphs. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 6:1-6:21, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{campanelli_et_al:LIPIcs.WABI.2025.6,
  author =	{Campanelli, Alessio and Pibiri, Giulio Ermanno and Patro, Rob},
  title =	{{Fast Pseudoalignment Queries on Compressed Colored de Bruijn Graphs}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{6:1--6:21},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.6},
  URN =		{urn:nbn:de:0030-drops-239327},
  doi =		{10.4230/LIPIcs.WABI.2025.6},
  annote =	{Keywords: Colored de Bruijn graphs, Pseudoalignment, Repetition-aware compression}
}
Document
DOI: 10.4230/LIPIcs.SEA.2024.3
Practical Minimum Path Cover

Authors: Manuel Cáceres, Brendan Mumey, Santeri Toivonen, and Alexandru I. Tomescu

Published in: LIPIcs, Volume 301, 22nd International Symposium on Experimental Algorithms (SEA 2024)

Abstract
Computing a minimum path cover (MPC) of a directed acyclic graph (DAG) is a fundamental problem with a myriad of applications, including reachability. Although it is known how to solve the problem by a simple reduction to minimum flow, recent theoretical advances exploit this idea to obtain algorithms parameterized by the number of paths of an MPC, known as the width. These results obtain fast [Mäkinen et al., TALG 2019] and even linear time [Cáceres et al., SODA 2022] algorithms in the small-width regime. In this paper, we present the first publicly available high-performance implementation of state-of-the-art MPC algorithms, including the parameterized approaches. Our experiments on random DAGs show that parameterized algorithms are orders-of-magnitude faster on dense graphs. Additionally, we present new fast pre-processing heuristics based on transitive edge sparsification. We show that our heuristics improve MPC-solvers by orders of magnitude.
Cite as

Manuel Cáceres, Brendan Mumey, Santeri Toivonen, and Alexandru I. Tomescu. Practical Minimum Path Cover. In 22nd International Symposium on Experimental Algorithms (SEA 2024). Leibniz International Proceedings in Informatics (LIPIcs), Volume 301, pp. 3:1-3:19, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2024)

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@InProceedings{caceres_et_al:LIPIcs.SEA.2024.3,
  author =	{C\'{a}ceres, Manuel and Mumey, Brendan and Toivonen, Santeri and Tomescu, Alexandru I.},
  title =	{{Practical Minimum Path Cover}},
  booktitle =	{22nd International Symposium on Experimental Algorithms (SEA 2024)},
  pages =	{3:1--3:19},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-325-6},
  ISSN =	{1868-8969},
  year =	{2024},
  volume =	{301},
  editor =	{Liberti, Leo},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.SEA.2024.3},
  URN =		{urn:nbn:de:0030-drops-203687},
  doi =		{10.4230/LIPIcs.SEA.2024.3},
  annote =	{Keywords: minimum path cover, directed acyclic graph, maximum flow, parameterized algorithms, edge sparsification, algorithm engineering}
}
Document
Track A: Algorithms, Complexity and Games
DOI: 10.4230/LIPIcs.ICALP.2023.31
Minimum Chain Cover in Almost Linear Time

Authors: Manuel Cáceres

Published in: LIPIcs, Volume 261, 50th International Colloquium on Automata, Languages, and Programming (ICALP 2023)

Abstract
A minimum chain cover (MCC) of a k-width directed acyclic graph (DAG) G = (V, E) is a set of k chains (paths in the transitive closure) of G such that every vertex appears in at least one chain in the cover. The state-of-the-art solutions for MCC run in time Õ(k(|V|+|E|)) [Mäkinen et at., TALG], O(T_{MF}(|E|) + k|V|), O(k²|V| + |E|) [Cáceres et al., SODA 2022], Õ(|V|^{3/2} + |E|) [Kogan and Parter, ICALP 2022] and Õ(T_{MCF}(|E|) + √k|V|) [Kogan and Parter, SODA 2023], where T_{MF}(|E|) and T_{MCF}(|E|) are the running times for solving maximum flow (MF) and minimum-cost flow (MCF), respectively. In this work we present an algorithm running in time O(T_{MF}(|E|) + (|V|+|E|)log k). By considering the recent result for solving MF [Chen et al., FOCS 2022] our algorithm is the first running in almost linear time. Moreover, our techniques are deterministic and derive a deterministic near-linear time algorithm for MCC if the same is provided for MF. At the core of our solution we use a modified version of the mergeable dictionaries [Farach and Thorup, Algorithmica], [Iacono and Özkan, ICALP 2010] data structure boosted with the SIZE-SPLIT operation and answering queries in amortized logarithmic time, which can be of independent interest.
Cite as

Manuel Cáceres. Minimum Chain Cover in Almost Linear Time. In 50th International Colloquium on Automata, Languages, and Programming (ICALP 2023). Leibniz International Proceedings in Informatics (LIPIcs), Volume 261, pp. 31:1-31:12, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2023)

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@InProceedings{caceres:LIPIcs.ICALP.2023.31,
  author =	{C\'{a}ceres, Manuel},
  title =	{{Minimum Chain Cover in Almost Linear Time}},
  booktitle =	{50th International Colloquium on Automata, Languages, and Programming (ICALP 2023)},
  pages =	{31:1--31:12},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-278-5},
  ISSN =	{1868-8969},
  year =	{2023},
  volume =	{261},
  editor =	{Etessami, Kousha and Feige, Uriel and Puppis, Gabriele},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ICALP.2023.31},
  URN =		{urn:nbn:de:0030-drops-180834},
  doi =		{10.4230/LIPIcs.ICALP.2023.31},
  annote =	{Keywords: Minimum chain cover, directed acyclic graph, minimum flow, flow decomposition, mergeable dictionaries, amortized running time}
}
Document
DOI: 10.4230/LIPIcs.ESA.2022.31
Width Helps and Hinders Splitting Flows

Authors: Manuel Cáceres, Massimo Cairo, Andreas Grigorjew, Shahbaz Khan, Brendan Mumey, Romeo Rizzi, Alexandru I. Tomescu, and Lucia Williams

Published in: LIPIcs, Volume 244, 30th Annual European Symposium on Algorithms (ESA 2022)

Abstract
Minimum flow decomposition (MFD) is the NP-hard problem of finding a smallest decomposition of a network flow X on directed graph G into weighted source-to-sink paths whose superposition equals X. We focus on a common formulation of the problem where the path weights must be non-negative integers and also on a new variant where these weights can be negative. We show that, for acyclic graphs, considering the width of the graph (the minimum number of s-t paths needed to cover all of its edges) yields advances in our understanding of its approximability. For the non-negative version, we show that a popular heuristic is a O(log |X|)-approximation (|X| being the total flow of X) on graphs satisfying two properties related to the width (satisfied by e.g., series-parallel graphs), and strengthen its worst-case approximation ratio from Ω(√m) to Ω(m / log m) for sparse graphs, where m is the number of edges in the graph. For the negative version, we give a (⌈log ║X║⌉+1)-approximation (║X║ being the maximum absolute value of X on any edge) using a power-of-two approach, combined with parity fixing arguments and a decomposition of unitary flows (║X║ ≤ 1) into at most width paths. We also disprove a conjecture about the linear independence of minimum (non-negative) flow decompositions posed by Kloster et al. [ALENEX 2018], but show that its useful implication (polynomial-time assignments of weights to a given set of paths to decompose a flow) holds for the negative version.
Cite as

Manuel Cáceres, Massimo Cairo, Andreas Grigorjew, Shahbaz Khan, Brendan Mumey, Romeo Rizzi, Alexandru I. Tomescu, and Lucia Williams. Width Helps and Hinders Splitting Flows. In 30th Annual European Symposium on Algorithms (ESA 2022). Leibniz International Proceedings in Informatics (LIPIcs), Volume 244, pp. 31:1-31:14, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2022)

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@InProceedings{caceres_et_al:LIPIcs.ESA.2022.31,
  author =	{C\'{a}ceres, Manuel and Cairo, Massimo and Grigorjew, Andreas and Khan, Shahbaz and Mumey, Brendan and Rizzi, Romeo and Tomescu, Alexandru I. and Williams, Lucia},
  title =	{{Width Helps and Hinders Splitting Flows}},
  booktitle =	{30th Annual European Symposium on Algorithms (ESA 2022)},
  pages =	{31:1--31:14},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-247-1},
  ISSN =	{1868-8969},
  year =	{2022},
  volume =	{244},
  editor =	{Chechik, Shiri and Navarro, Gonzalo and Rotenberg, Eva and Herman, Grzegorz},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ESA.2022.31},
  URN =		{urn:nbn:de:0030-drops-169695},
  doi =		{10.4230/LIPIcs.ESA.2022.31},
  annote =	{Keywords: Flow decomposition, approximation algorithms, graph width}
}
Document
DOI: 10.4230/LIPIcs.WABI.2021.16
Flow Decomposition with Subpath Constraints

Authors: Lucia Williams, Alexandru I. Tomescu, and Brendan Mumey

Published in: LIPIcs, Volume 201, 21st International Workshop on Algorithms in Bioinformatics (WABI 2021)

Abstract
Flow network decomposition is a natural model for problems where we are given a flow network arising from superimposing a set of weighted paths and would like to recover the underlying data, i.e., decompose the flow into the original paths and their weights. Thus, variations on flow decomposition are often used as subroutines in multiassembly problems such as RNA transcript assembly. In practice, we frequently have access to information beyond flow values in the form of subpaths, and many tools incorporate these heuristically. But despite acknowledging their utility in practice, previous work has not formally addressed the effect of subpath constraints on the accuracy of flow network decomposition approaches. We formalize the flow decomposition with subpath constraints problem, give the first algorithms for it, and study its usefulness for recovering ground truth decompositions. For finding a minimum decomposition, we propose both a heuristic and an FPT algorithm. Experiments on RNA transcript datasets show that for instances with larger solution path sets, the addition of subpath constraints finds 13% more ground truth solutions when minimal decompositions are found exactly, and 30% more ground truth solutions when minimal decompositions are found heuristically.
Cite as

Lucia Williams, Alexandru I. Tomescu, and Brendan Mumey. Flow Decomposition with Subpath Constraints. In 21st International Workshop on Algorithms in Bioinformatics (WABI 2021). Leibniz International Proceedings in Informatics (LIPIcs), Volume 201, pp. 16:1-16:15, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2021)

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@InProceedings{williams_et_al:LIPIcs.WABI.2021.16,
  author =	{Williams, Lucia and Tomescu, Alexandru I. and Mumey, Brendan},
  title =	{{Flow Decomposition with Subpath Constraints}},
  booktitle =	{21st International Workshop on Algorithms in Bioinformatics (WABI 2021)},
  pages =	{16:1--16:15},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-200-6},
  ISSN =	{1868-8969},
  year =	{2021},
  volume =	{201},
  editor =	{Carbone, Alessandra and El-Kebir, Mohammed},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2021.16},
  URN =		{urn:nbn:de:0030-drops-143695},
  doi =		{10.4230/LIPIcs.WABI.2021.16},
  annote =	{Keywords: Flow decomposition, subpath constraints, RNA-Seq}
}
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