10 Search Results for "Heath, John"


Document
Research
Native Provenance Computation for Federated and Non-Federated SPARQL Queries

Authors: Zubaria Asma, Daniel Hernández, Luis Galárraga, Giorgos Flouris, Irini Fundulaki, and Katja Hose

Published in: TGDK, Volume 4, Issue 1 (2026). Transactions on Graph Data and Knowledge, Volume 4, Issue 1


Abstract
The popularity of knowledge graphs (KGs) owes credit to their flexible data model, which is suitable for data integration from multiple sources. Several KG-based applications, such as trust assessment, view maintenance, or data valuation on dynamic data, rely on the ability to compute provenance explanations for query results. This need becomes more urgent in federated query processing systems, which allow the online consumption of heterogeneous and decentralized Web data. However, the problem of computing and interacting with provenance has received little attention, especially in the federated setting. On those grounds, this paper introduces the NPCS (Native Provenance Computation for SPARQL) approach, and its federated variant Fed-NPCS, that compute provenance for SPARQL query results. Both approaches build upon spm-semirings to annotate the results of monotonic and non-monotonic SPARQL queries with their provenance. Due to their reliance on query rewriting techniques, the approaches are directly applicable to already deployed SPARQL engines and federations using different reification schemes, including RDF-star. Our experimental evaluation shows that our novel query rewriting approach brings significant run-time improvements w.r.t. the state-of-the-art across both centralized and federated settings. In centralized settings, our tests on two popular SPARQL engines (GraphDB and Stardog) reveal substantial runtime gains over existing query rewriting solutions, enabling scalability to RDF graphs with billions of triples. In federated settings, our experiments on the FedShop benchmark with GraphDB show the viability of Fed-NPCS for federations with up to 200 sources.

Cite as

Zubaria Asma, Daniel Hernández, Luis Galárraga, Giorgos Flouris, Irini Fundulaki, and Katja Hose. Native Provenance Computation for Federated and Non-Federated SPARQL Queries. In Transactions on Graph Data and Knowledge (TGDK), Volume 4, Issue 1, pp. 4:1-4:43, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)


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@Article{asma_et_al:TGDK.4.1.4,
  author =	{Asma, Zubaria and Hern\'{a}ndez, Daniel and Gal\'{a}rraga, Luis and Flouris, Giorgos and Fundulaki, Irini and Hose, Katja},
  title =	{{Native Provenance Computation for Federated and Non-Federated SPARQL Queries}},
  journal =	{Transactions on Graph Data and Knowledge},
  pages =	{4:1--4:43},
  ISSN =	{2942-7517},
  year =	{2026},
  volume =	{4},
  number =	{1},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/TGDK.4.1.4},
  URN =		{urn:nbn:de:0030-drops-259642},
  doi =		{10.4230/TGDK.4.1.4},
  annote =	{Keywords: native provenance computation, federated SPARQL queries, data provenance, NPCS, Fed-NPCS}
}
Document
Forbidden Patterns in Mixed Linear Layouts

Authors: Deborah Haun, Laura Merker, and Sergey Pupyrev

Published in: LIPIcs, Volume 327, 42nd International Symposium on Theoretical Aspects of Computer Science (STACS 2025)


Abstract
An ordered graph is a graph with a total order over its vertices. A linear layout of an ordered graph is a partition of the edges into sets of either non-crossing edges, called stacks, or non-nesting edges, called queues. The stack (queue) number of an ordered graph is the minimum number of required stacks (queues). Mixed linear layouts combine these layouts by allowing each set of edges to form either a stack or a queue. The minimum number of stacks plus queues is called the mixed page number. It is well known that ordered graphs with small stack number are characterized, up to a function, by the absence of large twists (that is, pairwise crossing edges). Similarly, ordered graphs with small queue number are characterized by the absence of large rainbows (that is, pairwise nesting edges). However, no such characterization via forbidden patterns is known for mixed linear layouts. We address this gap by introducing patterns similar to twists and rainbows, which we call thick patterns; such patterns allow a characterization, again up to a function, of mixed linear layouts of bounded-degree graphs. That is, we show that a family of ordered graphs with bounded maximum degree has bounded mixed page number if and only if the size of the largest thick pattern is bounded. In addition, we investigate an exact characterization of ordered graphs whose mixed page number equals a fixed integer k via a finite set of forbidden patterns. We show that for k = 2, there is no such characterization, which supports the nature of our first result.

Cite as

Deborah Haun, Laura Merker, and Sergey Pupyrev. Forbidden Patterns in Mixed Linear Layouts. In 42nd International Symposium on Theoretical Aspects of Computer Science (STACS 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 327, pp. 45:1-45:21, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)


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@InProceedings{haun_et_al:LIPIcs.STACS.2025.45,
  author =	{Haun, Deborah and Merker, Laura and Pupyrev, Sergey},
  title =	{{Forbidden Patterns in Mixed Linear Layouts}},
  booktitle =	{42nd International Symposium on Theoretical Aspects of Computer Science (STACS 2025)},
  pages =	{45:1--45:21},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-365-2},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{327},
  editor =	{Beyersdorff, Olaf and Pilipczuk, Micha{\l} and Pimentel, Elaine and Thắng, Nguy\~{ê}n Kim},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.STACS.2025.45},
  URN =		{urn:nbn:de:0030-drops-228717},
  doi =		{10.4230/LIPIcs.STACS.2025.45},
  annote =	{Keywords: Ordered Graphs, linear Layout, mixed linear Layout, Stack Layout, Queue Layout}
}
Document
Unified Multimedia Segmentation - A Comprehensive Model for URI-based Media Segment Representation

Authors: Jan Willi, Abraham Bernstein, and Luca Rossetto

Published in: TGDK, Volume 2, Issue 3 (2024). Transactions on Graph Data and Knowledge, Volume 2, Issue 3


Abstract
In multimedia annotation, referencing specific segments of a document is often desired due to its richness and multimodality, but no universal representation for such references exists. This significantly hampers the usage of multimedia content in knowledge graphs, as it is modeled as one large atomic information container. Unstructured data - such as text, audio, images, and video - can commonly be decomposed into its constituent parts, as such documents rarely contain only one semantic concept. Hence, it is reasonable to assume that these advances will make it possible to decompose these previous atomic components into logical segments. To be processable by the knowledge graph stack, however, one needs to break the atomic nature of multimedia content, providing a mechanism to address media segments. This paper proposes a Unified Segmentation Model capable of depicting arbitrary segmentations on any media document type. The work begins with a formal analysis of multimedia and segmentation, exploring segmentation operations and how to describe them. Building on this analysis, it then develops a practical scheme for expressing segmentation in Uniform Resource Identifiers (URIs). Given that this approach makes segments of multimedia content referencable, it breaks their atomic nature and makes them first-class citizens within knowledge graphs. The proposed model is implemented as a proof of concept in the MediaGraph Store, a multimedia knowledge graph storage and querying engine.

Cite as

Jan Willi, Abraham Bernstein, and Luca Rossetto. Unified Multimedia Segmentation - A Comprehensive Model for URI-based Media Segment Representation. In Transactions on Graph Data and Knowledge (TGDK), Volume 2, Issue 3, pp. 1:1-1:34, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2024)


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@Article{willi_et_al:TGDK.2.3.1,
  author =	{Willi, Jan and Bernstein, Abraham and Rossetto, Luca},
  title =	{{Unified Multimedia Segmentation - A Comprehensive Model for URI-based Media Segment Representation}},
  journal =	{Transactions on Graph Data and Knowledge},
  pages =	{1:1--1:34},
  ISSN =	{2942-7517},
  year =	{2024},
  volume =	{2},
  number =	{3},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/TGDK.2.3.1},
  URN =		{urn:nbn:de:0030-drops-225953},
  doi =		{10.4230/TGDK.2.3.1},
  annote =	{Keywords: Multimodal Knowledge Graphs, Multimedia Segmentation, Multimedia Representation}
}
Document
Position
Grounding Stream Reasoning Research

Authors: Pieter Bonte, Jean-Paul Calbimonte, Daniel de Leng, Daniele Dell'Aglio, Emanuele Della Valle, Thomas Eiter, Federico Giannini, Fredrik Heintz, Konstantin Schekotihin, Danh Le-Phuoc, Alessandra Mileo, Patrik Schneider, Riccardo Tommasini, Jacopo Urbani, and Giacomo Ziffer

Published in: TGDK, Volume 2, Issue 1 (2024): Special Issue on Trends in Graph Data and Knowledge - Part 2. Transactions on Graph Data and Knowledge, Volume 2, Issue 1


Abstract
In the last decade, there has been a growing interest in applying AI technologies to implement complex data analytics over data streams. To this end, researchers in various fields have been organising a yearly event called the "Stream Reasoning Workshop" to share perspectives, challenges, and experiences around this topic. In this paper, the previous organisers of the workshops and other community members provide a summary of the main research results that have been discussed during the first six editions of the event. These results can be categorised into four main research areas: The first is concerned with the technological challenges related to handling large data streams. The second area aims at adapting and extending existing semantic technologies to data streams. The third and fourth areas focus on how to implement reasoning techniques, either considering deductive or inductive techniques, to extract new and valuable knowledge from the data in the stream. This summary is written not only to provide a crystallisation of the field, but also to point out distinctive traits of the stream reasoning community. Moreover, it also provides a foundation for future research by enumerating a list of use cases and open challenges, to stimulate others to join this exciting research area.

Cite as

Pieter Bonte, Jean-Paul Calbimonte, Daniel de Leng, Daniele Dell'Aglio, Emanuele Della Valle, Thomas Eiter, Federico Giannini, Fredrik Heintz, Konstantin Schekotihin, Danh Le-Phuoc, Alessandra Mileo, Patrik Schneider, Riccardo Tommasini, Jacopo Urbani, and Giacomo Ziffer. Grounding Stream Reasoning Research. In Special Issue on Trends in Graph Data and Knowledge - Part 2. Transactions on Graph Data and Knowledge (TGDK), Volume 2, Issue 1, pp. 2:1-2:47, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2024)


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@Article{bonte_et_al:TGDK.2.1.2,
  author =	{Bonte, Pieter and Calbimonte, Jean-Paul and de Leng, Daniel and Dell'Aglio, Daniele and Della Valle, Emanuele and Eiter, Thomas and Giannini, Federico and Heintz, Fredrik and Schekotihin, Konstantin and Le-Phuoc, Danh and Mileo, Alessandra and Schneider, Patrik and Tommasini, Riccardo and Urbani, Jacopo and Ziffer, Giacomo},
  title =	{{Grounding Stream Reasoning Research}},
  journal =	{Transactions on Graph Data and Knowledge},
  pages =	{2:1--2:47},
  ISSN =	{2942-7517},
  year =	{2024},
  volume =	{2},
  number =	{1},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/TGDK.2.1.2},
  URN =		{urn:nbn:de:0030-drops-198597},
  doi =		{10.4230/TGDK.2.1.2},
  annote =	{Keywords: Stream Reasoning, Stream Processing, RDF streams, Streaming Linked Data, Continuous query processing, Temporal Logics, High-performance computing, Databases}
}
Document
Survey
Semantic Web: Past, Present, and Future

Authors: Ansgar Scherp, Gerd Groener, Petr Škoda, Katja Hose, and Maria-Esther Vidal

Published in: TGDK, Volume 2, Issue 1 (2024): Special Issue on Trends in Graph Data and Knowledge - Part 2. Transactions on Graph Data and Knowledge, Volume 2, Issue 1


Abstract
Ever since the vision was formulated, the Semantic Web has inspired many generations of innovations. Semantic technologies have been used to share vast amounts of information on the Web, enhance them with semantics to give them meaning, and enable inference and reasoning on them. Throughout the years, semantic technologies, and in particular knowledge graphs, have been used in search engines, data integration, enterprise settings, and machine learning. In this paper, we recap the classical concepts and foundations of the Semantic Web as well as modern and recent concepts and applications, building upon these foundations. The classical topics we cover include knowledge representation, creating and validating knowledge on the Web, reasoning and linking, and distributed querying. We enhance this classical view of the so-called "Semantic Web Layer Cake" with an update of recent concepts that include provenance, security and trust, as well as a discussion of practical impacts from industry-led contributions. We conclude with an outlook on the future directions of the Semantic Web. This is a living document. If you like to contribute, please contact the first author and visit: https://github.com/ascherp/semantic-web-primer

Cite as

Ansgar Scherp, Gerd Groener, Petr Škoda, Katja Hose, and Maria-Esther Vidal. Semantic Web: Past, Present, and Future. In Special Issue on Trends in Graph Data and Knowledge - Part 2. Transactions on Graph Data and Knowledge (TGDK), Volume 2, Issue 1, pp. 3:1-3:37, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2024)


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@Article{scherp_et_al:TGDK.2.1.3,
  author =	{Scherp, Ansgar and Groener, Gerd and \v{S}koda, Petr and Hose, Katja and Vidal, Maria-Esther},
  title =	{{Semantic Web: Past, Present, and Future}},
  journal =	{Transactions on Graph Data and Knowledge},
  pages =	{3:1--3:37},
  ISSN =	{2942-7517},
  year =	{2024},
  volume =	{2},
  number =	{1},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/TGDK.2.1.3},
  URN =		{urn:nbn:de:0030-drops-198607},
  doi =		{10.4230/TGDK.2.1.3},
  annote =	{Keywords: Linked Open Data, Semantic Web Graphs, Knowledge Graphs}
}
Document
Survey
Towards Representing Processes and Reasoning with Process Descriptions on the Web

Authors: Andreas Harth, Tobias Käfer, Anisa Rula, Jean-Paul Calbimonte, Eduard Kamburjan, and Martin Giese

Published in: TGDK, Volume 2, Issue 1 (2024): Special Issue on Trends in Graph Data and Knowledge - Part 2. Transactions on Graph Data and Knowledge, Volume 2, Issue 1


Abstract
We work towards a vocabulary to represent processes and temporal logic specifications as graph-structured data. Different fields use incompatible terminologies for describing essentially the same process-related concepts. In addition, processes can be represented from different perspectives and levels of abstraction: both state-centric and event-centric perspectives offer distinct insights into the underlying processes. In this work, we strive to unify the representation of processes and related concepts by leveraging the power of knowledge graphs. We survey approaches to representing processes and reasoning with process descriptions from different fields and provide a selection of scenarios to help inform the scope of a unified representation of processes. We focus on processes that can be executed and observed via web interfaces. We propose to provide a representation designed to combine state-centric and event-centric perspectives while incorporating temporal querying and reasoning capabilities on temporal logic specifications. A standardised vocabulary and representation for processes and temporal specifications would contribute towards bridging the gap between the terminologies from different fields and fostering the broader application of methods involving temporal logics, such as formal verification and program synthesis.

Cite as

Andreas Harth, Tobias Käfer, Anisa Rula, Jean-Paul Calbimonte, Eduard Kamburjan, and Martin Giese. Towards Representing Processes and Reasoning with Process Descriptions on the Web. In Special Issue on Trends in Graph Data and Knowledge - Part 2. Transactions on Graph Data and Knowledge (TGDK), Volume 2, Issue 1, pp. 1:1-1:32, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2024)


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@Article{harth_et_al:TGDK.2.1.1,
  author =	{Harth, Andreas and K\"{a}fer, Tobias and Rula, Anisa and Calbimonte, Jean-Paul and Kamburjan, Eduard and Giese, Martin},
  title =	{{Towards Representing Processes and Reasoning with Process Descriptions on the Web}},
  journal =	{Transactions on Graph Data and Knowledge},
  pages =	{1:1--1:32},
  ISSN =	{2942-7517},
  year =	{2024},
  volume =	{2},
  number =	{1},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/TGDK.2.1.1},
  URN =		{urn:nbn:de:0030-drops-198583},
  doi =		{10.4230/TGDK.2.1.1},
  annote =	{Keywords: Process modelling, Process ontology, Temporal logic, Web services}
}
Document
Survey
How Does Knowledge Evolve in Open Knowledge Graphs?

Authors: Axel Polleres, Romana Pernisch, Angela Bonifati, Daniele Dell'Aglio, Daniil Dobriy, Stefania Dumbrava, Lorena Etcheverry, Nicolas Ferranti, Katja Hose, Ernesto Jiménez-Ruiz, Matteo Lissandrini, Ansgar Scherp, Riccardo Tommasini, and Johannes Wachs

Published in: TGDK, Volume 1, Issue 1 (2023): Special Issue on Trends in Graph Data and Knowledge. Transactions on Graph Data and Knowledge, Volume 1, Issue 1


Abstract
Openly available, collaboratively edited Knowledge Graphs (KGs) are key platforms for the collective management of evolving knowledge. The present work aims t o provide an analysis of the obstacles related to investigating and processing specifically this central aspect of evolution in KGs. To this end, we discuss (i) the dimensions of evolution in KGs, (ii) the observability of evolution in existing, open, collaboratively constructed Knowledge Graphs over time, and (iii) possible metrics to analyse this evolution. We provide an overview of relevant state-of-the-art research, ranging from metrics developed for Knowledge Graphs specifically to potential methods from related fields such as network science. Additionally, we discuss technical approaches - and their current limitations - related to storing, analysing and processing large and evolving KGs in terms of handling typical KG downstream tasks.

Cite as

Axel Polleres, Romana Pernisch, Angela Bonifati, Daniele Dell'Aglio, Daniil Dobriy, Stefania Dumbrava, Lorena Etcheverry, Nicolas Ferranti, Katja Hose, Ernesto Jiménez-Ruiz, Matteo Lissandrini, Ansgar Scherp, Riccardo Tommasini, and Johannes Wachs. How Does Knowledge Evolve in Open Knowledge Graphs?. In Special Issue on Trends in Graph Data and Knowledge. Transactions on Graph Data and Knowledge (TGDK), Volume 1, Issue 1, pp. 11:1-11:59, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2023)


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@Article{polleres_et_al:TGDK.1.1.11,
  author =	{Polleres, Axel and Pernisch, Romana and Bonifati, Angela and Dell'Aglio, Daniele and Dobriy, Daniil and Dumbrava, Stefania and Etcheverry, Lorena and Ferranti, Nicolas and Hose, Katja and Jim\'{e}nez-Ruiz, Ernesto and Lissandrini, Matteo and Scherp, Ansgar and Tommasini, Riccardo and Wachs, Johannes},
  title =	{{How Does Knowledge Evolve in Open Knowledge Graphs?}},
  journal =	{Transactions on Graph Data and Knowledge},
  pages =	{11:1--11:59},
  year =	{2023},
  volume =	{1},
  number =	{1},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/TGDK.1.1.11},
  URN =		{urn:nbn:de:0030-drops-194855},
  doi =		{10.4230/TGDK.1.1.11},
  annote =	{Keywords: KG evolution, temporal KG, versioned KG, dynamic KG}
}
Document
Vision
Autonomy in the Age of Knowledge Graphs: Vision and Challenges

Authors: Jean-Paul Calbimonte, Andrei Ciortea, Timotheus Kampik, Simon Mayer, Terry R. Payne, Valentina Tamma, and Antoine Zimmermann

Published in: TGDK, Volume 1, Issue 1 (2023): Special Issue on Trends in Graph Data and Knowledge. Transactions on Graph Data and Knowledge, Volume 1, Issue 1


Abstract
In this position paper, we propose that Knowledge Graphs (KGs) are one of the prime approaches to support the programming of autonomous software systems at the knowledge level. From this viewpoint, we survey how KGs can support different dimensions of autonomy in such systems: For example, the autonomy of systems with respect to their environment, or with respect to organisations; and we discuss related practical and research challenges. We emphasise that KGs need to be able to support systems of autonomous software agents that are themselves highly heterogeneous, which limits how these systems may use KGs. Furthermore, these heterogeneous software agents may populate highly dynamic environments, which implies that they require adaptive KGs. The scale of the envisioned systems - possibly stretching to the size of the Internet - highlights the maintainability of the underlying KGs that need to contain large-scale knowledge, which requires that KGs are maintained jointly by humans and machines. Furthermore, autonomous agents require procedural knowledge, and KGs should hence be explored more towards the provisioning of such knowledge to augment autonomous behaviour. Finally, we highlight the importance of modelling choices, including with respect to the selected abstraction level when modelling and with respect to the provisioning of more expressive constraint languages.

Cite as

Jean-Paul Calbimonte, Andrei Ciortea, Timotheus Kampik, Simon Mayer, Terry R. Payne, Valentina Tamma, and Antoine Zimmermann. Autonomy in the Age of Knowledge Graphs: Vision and Challenges. In Special Issue on Trends in Graph Data and Knowledge. Transactions on Graph Data and Knowledge (TGDK), Volume 1, Issue 1, pp. 13:1-13:22, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2023)


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@Article{calbimonte_et_al:TGDK.1.1.13,
  author =	{Calbimonte, Jean-Paul and Ciortea, Andrei and Kampik, Timotheus and Mayer, Simon and Payne, Terry R. and Tamma, Valentina and Zimmermann, Antoine},
  title =	{{Autonomy in the Age of Knowledge Graphs: Vision and Challenges}},
  journal =	{Transactions on Graph Data and Knowledge},
  pages =	{13:1--13:22},
  ISSN =	{2942-7517},
  year =	{2023},
  volume =	{1},
  number =	{1},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/TGDK.1.1.13},
  URN =		{urn:nbn:de:0030-drops-194872},
  doi =		{10.4230/TGDK.1.1.13},
  annote =	{Keywords: Knowledge graphs, Autonomous Systems}
}
Document
Vision
Knowledge Engineering Using Large Language Models

Authors: Bradley P. Allen, Lise Stork, and Paul Groth

Published in: TGDK, Volume 1, Issue 1 (2023): Special Issue on Trends in Graph Data and Knowledge. Transactions on Graph Data and Knowledge, Volume 1, Issue 1


Abstract
Knowledge engineering is a discipline that focuses on the creation and maintenance of processes that generate and apply knowledge. Traditionally, knowledge engineering approaches have focused on knowledge expressed in formal languages. The emergence of large language models and their capabilities to effectively work with natural language, in its broadest sense, raises questions about the foundations and practice of knowledge engineering. Here, we outline the potential role of LLMs in knowledge engineering, identifying two central directions: 1) creating hybrid neuro-symbolic knowledge systems; and 2) enabling knowledge engineering in natural language. Additionally, we formulate key open research questions to tackle these directions.

Cite as

Bradley P. Allen, Lise Stork, and Paul Groth. Knowledge Engineering Using Large Language Models. In Special Issue on Trends in Graph Data and Knowledge. Transactions on Graph Data and Knowledge (TGDK), Volume 1, Issue 1, pp. 3:1-3:19, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2023)


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@Article{allen_et_al:TGDK.1.1.3,
  author =	{Allen, Bradley P. and Stork, Lise and Groth, Paul},
  title =	{{Knowledge Engineering Using Large Language Models}},
  journal =	{Transactions on Graph Data and Knowledge},
  pages =	{3:1--3:19},
  ISSN =	{2942-7517},
  year =	{2023},
  volume =	{1},
  number =	{1},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/TGDK.1.1.3},
  URN =		{urn:nbn:de:0030-drops-194777},
  doi =		{10.4230/TGDK.1.1.3},
  annote =	{Keywords: knowledge engineering, large language models}
}
Document
Modelling and analysis of the NF-$kappa$B pathway in Bio-PEPA

Authors: Federica Ciocchetta, Andrea Degasperi, John Heath, and Jane Hillston

Published in: Dagstuhl Seminar Proceedings, Volume 9091, Formal Methods in Molecular Biology (2009)


Abstract
In this work we present a Bio-PEPA model describing the Nuclear Factor $kappa$B (NF-$kappa$B) signalling pathway. In particular our model focuses on the dynamic response of NF-$kappa$B to an external stimulus. Each biochemical species in the pathway is represented by a specific Bio-PEPA component and the external stimulus is abstracted by Bio-PEPA events. The Bio-PEPA model is a formal intermediate representation of the pathway on which various kinds of analysis can be performed. Both stochastic and deterministic simulations are carried out to validate our model against the experimental data in the literature and to verify some properties, such as the impact of the stimulus duration and of the NF-$kappa$B initial amount on the behaviour of some species. Finally, sensitivity analysis is considered to investigate the most influential parameters of the model.

Cite as

Federica Ciocchetta, Andrea Degasperi, John Heath, and Jane Hillston. Modelling and analysis of the NF-$kappa$B pathway in Bio-PEPA. In Formal Methods in Molecular Biology. Dagstuhl Seminar Proceedings, Volume 9091, pp. 1-18, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2009)


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@InProceedings{ciocchetta_et_al:DagSemProc.09091.5,
  author =	{Ciocchetta, Federica and Degasperi, Andrea and Heath, John and Hillston, Jane},
  title =	{{Modelling and analysis of the NF-\$kappa\$B pathway in Bio-PEPA}},
  booktitle =	{Formal Methods in Molecular Biology},
  pages =	{1--18},
  series =	{Dagstuhl Seminar Proceedings (DagSemProc)},
  ISSN =	{1862-4405},
  year =	{2009},
  volume =	{9091},
  editor =	{Rainer Breitling and David Roger Gilbert and Monika Heiner and Corrado Priami},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/DagSemProc.09091.5},
  URN =		{urn:nbn:de:0030-drops-19911},
  doi =		{10.4230/DagSemProc.09091.5},
  annote =	{Keywords: Process algebras, NF-\$kappa\$B pathway, modelling, analysis}
}
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