8 Search Results for "Ye, Katherine"


Document
Toward an Earth-Independent System for EVA Mission Planning: Integrating Physical Models, Domain Knowledge, and Agentic RAG to Provide Explainable LLM-Based Decision Support

Authors: Kaisheng Li and Richard S. Whittle

Published in: OASIcs, Volume 130, Advancing Human-Computer Interaction for Space Exploration (SpaceCHI 2025)


Abstract
We propose a unified framework for an Earth‑independent AI system that provides explainable, context‑aware decision support for EVA mission planning by integrating six core components: a fine‑tuned EVA domain LLM, a retrieval‑augmented knowledge base, a short-term memory store, physical simulation models, an agentic orchestration layer, and a multimodal user interface. To ground our design, we analyze the current roles and substitution potential of the Mission Control Center - identifying which procedural and analytical functions can be automated onboard while preserving human oversight for experiential and strategic tasks. Building on this framework, we introduce RASAGE (Retrieval & Simulation Augmented Guidance Agent for Exploration), a proof‑of‑concept toolset that combines Microsoft Phi‑4‑mini‑instruct with a FAISS (Facebook AI Similarity Search)‑powered EVA knowledge base and custom A* path planning and hypogravity metabolic models to generate grounded, traceable EVA plans. We outline a staged validation strategy to evaluate improvements in route efficiency, metabolic prediction accuracy, anomaly response effectiveness, and crew trust under realistic communication delays. Our findings demonstrate the feasibility of replicating key Mission Control functions onboard, enhancing crew autonomy, reducing cognitive load, and improving safety for deep‑space exploration missions.

Cite as

Kaisheng Li and Richard S. Whittle. Toward an Earth-Independent System for EVA Mission Planning: Integrating Physical Models, Domain Knowledge, and Agentic RAG to Provide Explainable LLM-Based Decision Support. In Advancing Human-Computer Interaction for Space Exploration (SpaceCHI 2025). Open Access Series in Informatics (OASIcs), Volume 130, pp. 6:1-6:17, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)


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@InProceedings{li_et_al:OASIcs.SpaceCHI.2025.6,
  author =	{Li, Kaisheng and Whittle, Richard S.},
  title =	{{Toward an Earth-Independent System for EVA Mission Planning: Integrating Physical Models, Domain Knowledge, and Agentic RAG to Provide Explainable LLM-Based Decision Support}},
  booktitle =	{Advancing Human-Computer Interaction for Space Exploration (SpaceCHI 2025)},
  pages =	{6:1--6:17},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-384-3},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{130},
  editor =	{Bensch, Leonie and Nilsson, Tommy and Nisser, Martin and Pataranutaporn, Pat and Schmidt, Albrecht and Sumini, Valentina},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.SpaceCHI.2025.6},
  URN =		{urn:nbn:de:0030-drops-239967},
  doi =		{10.4230/OASIcs.SpaceCHI.2025.6},
  annote =	{Keywords: Human-AI Interaction for Space Exploration, Extravehicular Activities, Cognitive load and Human Performance Issues, Human Systems Exploration, Lunar Exploration, LLM}
}
Document
DiVerG: Scalable Distance Index for Validation of Paired-End Alignments in Sequence Graphs

Authors: Ali Ghaffaari, Alexander Schönhuth, and Tobias Marschall

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)


Abstract
Determining the distance between two loci within a genomic region is a recurrent operation in various tasks in computational genomics. A notable example of this task arises in paired-end read mapping as a form of validation of distances between multiple alignments. While straightforward for a single genome, graph-based reference structures render the operation considerably more involved. Given the sheer number of such queries in a typical read mapping experiment, an efficient algorithm for answering distance queries is crucial. In this paper, we introduce DiVerG, a compact data structure as well as a fast and scalable algorithm, for constructing distance indexes for general sequence graphs on multi-core CPU and many-core GPU architectures. DiVerG is based on PairG [Jain et al., 2019], but overcomes the limitations of PairG by exploiting the extensive potential for improvements in terms of scalability and space efficiency. As a consequence, DiVerG can process substantially larger datasets, such as whole human genomes, which are unmanageable by PairG. DiVerG offers faster index construction time and consistently faster query time with gains proportional to the size of the underlying compact data structure. We demonstrate that our method performs favorably on multiple real datasets at various scales. DiVerG achieves superior performance over PairG; e.g. resulting to 2.5-4x speed-up in query time, 44-340x smaller index size, and 3-50x faster construction time for the genome graph of the MHC region, as a particularly variable region of the human genome. The implementation is available at: https://github.com/cartoonist/diverg

Cite as

Ali Ghaffaari, Alexander Schönhuth, and Tobias Marschall. DiVerG: Scalable Distance Index for Validation of Paired-End Alignments in Sequence Graphs. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 10:1-10:24, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)


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@InProceedings{ghaffaari_et_al:LIPIcs.WABI.2025.10,
  author =	{Ghaffaari, Ali and Sch\"{o}nhuth, Alexander and Marschall, Tobias},
  title =	{{DiVerG: Scalable Distance Index for Validation of Paired-End Alignments in Sequence Graphs}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{10:1--10:24},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.10},
  URN =		{urn:nbn:de:0030-drops-239369},
  doi =		{10.4230/LIPIcs.WABI.2025.10},
  annote =	{Keywords: Sequence graph, distance index, read mapping, sparse matrix}
}
Document
Human Readable Compression of GFA Paths Using Grammar-Based Code

Authors: Peter Heringer and Daniel Doerr

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)


Abstract
Pangenome graphs offer a compact and comprehensive representation of genomic diversity, improving tasks such as variant calling, genotyping, and other downstream analyses. Although the underlying graph structures scale sublinearly with the number of haplotypes, the widely used GFA file format suffers from rapidly growing file sizes due to the explicit and repetitive encoding of haplotype paths. In this work, we introduce an extension to the GFA format that enables efficient grammar-based compression of haplotype paths while retaining human readability. In addition, grammar-based encoding provides an efficient in-memory data structure that does not require decompression, but conversely improves the runtime of many computational tasks that involve haplotype comparisons. We present sqz, a method that makes use of the proposed format extension to encode haplotype paths using byte pair encoding, a grammar-based compression scheme. We evaluate sqz on recent human pangenome graphs from Heumos et al. and the Human Pangenome Reference Consortium (HPRC), comparing it to existing compressors bgzip, gbz, and sequitur. sqz scales sublinearly with the number of haplotypes in a pangenome graph and consistently achieves higher compression ratios than sequitur and up to 5 times better compression than bgzip in HPRC graphs and up to 10 times in the graph from Heumos et al.. When combined with bgzip, sqz matches or excels the compression ratio of gbz across all our datasets. These results demonstrate the potential of our proposed extension of the GFA format in reducing haplotype path redundancy and improving storage efficiency for pangenome graphs.

Cite as

Peter Heringer and Daniel Doerr. Human Readable Compression of GFA Paths Using Grammar-Based Code. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 14:1-14:19, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)


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@InProceedings{heringer_et_al:LIPIcs.WABI.2025.14,
  author =	{Heringer, Peter and Doerr, Daniel},
  title =	{{Human Readable Compression of GFA Paths Using Grammar-Based Code}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{14:1--14:19},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.14},
  URN =		{urn:nbn:de:0030-drops-239395},
  doi =		{10.4230/LIPIcs.WABI.2025.14},
  annote =	{Keywords: pangenomics, pangenome graphs, compression, grammar-based code, byte pair encoding}
}
Document
Track A: Algorithms, Complexity and Games
Incremental Approximate Single-Source Shortest Paths with Predictions

Authors: Samuel McCauley, Benjamin Moseley, Aidin Niaparast, Helia Niaparast, and Shikha Singh

Published in: LIPIcs, Volume 334, 52nd International Colloquium on Automata, Languages, and Programming (ICALP 2025)


Abstract
The algorithms-with-predictions framework has been used extensively to develop online algorithms with improved beyond-worst-case competitive ratios. Recently, there is growing interest in leveraging predictions for designing data structures with improved beyond-worst-case running times. In this paper, we study the fundamental data structure problem of maintaining approximate shortest paths in incremental graphs in the algorithms-with-predictions model. Given a sequence σ of edges that are inserted one at a time, the goal is to maintain approximate shortest paths from the source to each vertex in the graph at each time step. Before any edges arrive, the data structure is given a prediction of the online edge sequence σ̂ which is used to "warm start" its state. As our main result, we design a learned algorithm that maintains (1+ε)-approximate single-source shortest paths, which runs in Õ(m η log W/ε) time, where W is the weight of the heaviest edge and η is the prediction error. We show these techniques immediately extend to the all-pairs shortest-path setting as well. Our algorithms are consistent (performing nearly as fast as the offline algorithm) when predictions are nearly perfect, have a smooth degradation in performance with respect to the prediction error and, in the worst case, match the best offline algorithm up to logarithmic factors. That is, the algorithms are "ideal" in the algorithms-with-predictions model. As a building block, we study the offline incremental approximate single-source shortest-path (SSSP) problem. In the offline incremental SSSP problem, the edge sequence σ is known a priori and the goal is to construct a data structure that can efficiently return the length of the shortest paths in the intermediate graph G_t consisting of the first t edges, for all t. Note that the offline incremental problem is defined in the worst-case setting (without predictions) and is of independent interest.

Cite as

Samuel McCauley, Benjamin Moseley, Aidin Niaparast, Helia Niaparast, and Shikha Singh. Incremental Approximate Single-Source Shortest Paths with Predictions. In 52nd International Colloquium on Automata, Languages, and Programming (ICALP 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 334, pp. 117:1-117:20, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)


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@InProceedings{mccauley_et_al:LIPIcs.ICALP.2025.117,
  author =	{McCauley, Samuel and Moseley, Benjamin and Niaparast, Aidin and Niaparast, Helia and Singh, Shikha},
  title =	{{Incremental Approximate Single-Source Shortest Paths with Predictions}},
  booktitle =	{52nd International Colloquium on Automata, Languages, and Programming (ICALP 2025)},
  pages =	{117:1--117:20},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-372-0},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{334},
  editor =	{Censor-Hillel, Keren and Grandoni, Fabrizio and Ouaknine, Jo\"{e}l and Puppis, Gabriele},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ICALP.2025.117},
  URN =		{urn:nbn:de:0030-drops-234946},
  doi =		{10.4230/LIPIcs.ICALP.2025.117},
  annote =	{Keywords: Algorithms with Predictions, Shortest Paths, Approximation Algorithms, Dynamic Graph Algorithms}
}
Document
Position
Standardizing Knowledge Engineering Practices with a Reference Architecture

Authors: Bradley P. Allen and Filip Ilievski

Published in: TGDK, Volume 2, Issue 1 (2024): Special Issue on Trends in Graph Data and Knowledge - Part 2. Transactions on Graph Data and Knowledge, Volume 2, Issue 1


Abstract
Knowledge engineering is the process of creating and maintaining knowledge-producing systems. Throughout the history of computer science and AI, knowledge engineering workflows have been widely used given the importance of high-quality knowledge for reliable intelligent agents. Meanwhile, the scope of knowledge engineering, as apparent from its target tasks and use cases, has been shifting, together with its paradigms such as expert systems, semantic web, and language modeling. The intended use cases and supported user requirements between these paradigms have not been analyzed globally, as new paradigms often satisfy prior pain points while possibly introducing new ones. The recent abstraction of systemic patterns into a boxology provides an opening for aligning the requirements and use cases of knowledge engineering with the systems, components, and software that can satisfy them best, however, this direction has not been explored to date. This paper proposes a vision of harmonizing the best practices in the field of knowledge engineering by leveraging the software engineering methodology of creating reference architectures. We describe how a reference architecture can be iteratively designed and implemented to associate user needs with recurring systemic patterns, building on top of existing knowledge engineering workflows and boxologies. We provide a six-step roadmap that can enable the development of such an architecture, consisting of scope definition, selection of information sources, architectural analysis, synthesis of an architecture based on the information source analysis, evaluation through instantiation, and, ultimately, instantiation into a concrete software architecture. We provide an initial design and outcome of the definition of architectural scope, selection of information sources, and analysis. As the remaining steps of design, evaluation, and instantiation of the architecture are largely use-case specific, we provide a detailed description of their procedures and point to relevant examples. We expect that following through on this vision will lead to well-grounded reference architectures for knowledge engineering, will advance the ongoing initiatives of organizing the neurosymbolic knowledge engineering space, and will build new links to the software architectures and data science communities.

Cite as

Bradley P. Allen and Filip Ilievski. Standardizing Knowledge Engineering Practices with a Reference Architecture. In Special Issue on Trends in Graph Data and Knowledge - Part 2. Transactions on Graph Data and Knowledge (TGDK), Volume 2, Issue 1, pp. 5:1-5:23, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2024)


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@Article{allen_et_al:TGDK.2.1.5,
  author =	{Allen, Bradley P. and Ilievski, Filip},
  title =	{{Standardizing Knowledge Engineering Practices with a Reference Architecture}},
  journal =	{Transactions on Graph Data and Knowledge},
  pages =	{5:1--5:23},
  ISSN =	{2942-7517},
  year =	{2024},
  volume =	{2},
  number =	{1},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/TGDK.2.1.5},
  URN =		{urn:nbn:de:0030-drops-198623},
  doi =		{10.4230/TGDK.2.1.5},
  annote =	{Keywords: knowledge engineering, knowledge graphs, quality attributes, software architectures, sociotechnical systems}
}
Document
Position
Large Language Models and Knowledge Graphs: Opportunities and Challenges

Authors: Jeff Z. Pan, Simon Razniewski, Jan-Christoph Kalo, Sneha Singhania, Jiaoyan Chen, Stefan Dietze, Hajira Jabeen, Janna Omeliyanenko, Wen Zhang, Matteo Lissandrini, Russa Biswas, Gerard de Melo, Angela Bonifati, Edlira Vakaj, Mauro Dragoni, and Damien Graux

Published in: TGDK, Volume 1, Issue 1 (2023): Special Issue on Trends in Graph Data and Knowledge. Transactions on Graph Data and Knowledge, Volume 1, Issue 1


Abstract
Large Language Models (LLMs) have taken Knowledge Representation - and the world - by storm. This inflection point marks a shift from explicit knowledge representation to a renewed focus on the hybrid representation of both explicit knowledge and parametric knowledge. In this position paper, we will discuss some of the common debate points within the community on LLMs (parametric knowledge) and Knowledge Graphs (explicit knowledge) and speculate on opportunities and visions that the renewed focus brings, as well as related research topics and challenges.

Cite as

Jeff Z. Pan, Simon Razniewski, Jan-Christoph Kalo, Sneha Singhania, Jiaoyan Chen, Stefan Dietze, Hajira Jabeen, Janna Omeliyanenko, Wen Zhang, Matteo Lissandrini, Russa Biswas, Gerard de Melo, Angela Bonifati, Edlira Vakaj, Mauro Dragoni, and Damien Graux. Large Language Models and Knowledge Graphs: Opportunities and Challenges. In Special Issue on Trends in Graph Data and Knowledge. Transactions on Graph Data and Knowledge (TGDK), Volume 1, Issue 1, pp. 2:1-2:38, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2023)


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@Article{pan_et_al:TGDK.1.1.2,
  author =	{Pan, Jeff Z. and Razniewski, Simon and Kalo, Jan-Christoph and Singhania, Sneha and Chen, Jiaoyan and Dietze, Stefan and Jabeen, Hajira and Omeliyanenko, Janna and Zhang, Wen and Lissandrini, Matteo and Biswas, Russa and de Melo, Gerard and Bonifati, Angela and Vakaj, Edlira and Dragoni, Mauro and Graux, Damien},
  title =	{{Large Language Models and Knowledge Graphs: Opportunities and Challenges}},
  journal =	{Transactions on Graph Data and Knowledge},
  pages =	{2:1--2:38},
  year =	{2023},
  volume =	{1},
  number =	{1},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/TGDK.1.1.2},
  URN =		{urn:nbn:de:0030-drops-194766},
  doi =		{10.4230/TGDK.1.1.2},
  annote =	{Keywords: Large Language Models, Pre-trained Language Models, Knowledge Graphs, Ontology, Retrieval Augmented Language Models}
}
Document
Vision
Knowledge Engineering Using Large Language Models

Authors: Bradley P. Allen, Lise Stork, and Paul Groth

Published in: TGDK, Volume 1, Issue 1 (2023): Special Issue on Trends in Graph Data and Knowledge. Transactions on Graph Data and Knowledge, Volume 1, Issue 1


Abstract
Knowledge engineering is a discipline that focuses on the creation and maintenance of processes that generate and apply knowledge. Traditionally, knowledge engineering approaches have focused on knowledge expressed in formal languages. The emergence of large language models and their capabilities to effectively work with natural language, in its broadest sense, raises questions about the foundations and practice of knowledge engineering. Here, we outline the potential role of LLMs in knowledge engineering, identifying two central directions: 1) creating hybrid neuro-symbolic knowledge systems; and 2) enabling knowledge engineering in natural language. Additionally, we formulate key open research questions to tackle these directions.

Cite as

Bradley P. Allen, Lise Stork, and Paul Groth. Knowledge Engineering Using Large Language Models. In Special Issue on Trends in Graph Data and Knowledge. Transactions on Graph Data and Knowledge (TGDK), Volume 1, Issue 1, pp. 3:1-3:19, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2023)


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@Article{allen_et_al:TGDK.1.1.3,
  author =	{Allen, Bradley P. and Stork, Lise and Groth, Paul},
  title =	{{Knowledge Engineering Using Large Language Models}},
  journal =	{Transactions on Graph Data and Knowledge},
  pages =	{3:1--3:19},
  ISSN =	{2942-7517},
  year =	{2023},
  volume =	{1},
  number =	{1},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/TGDK.1.1.3},
  URN =		{urn:nbn:de:0030-drops-194777},
  doi =		{10.4230/TGDK.1.1.3},
  annote =	{Keywords: knowledge engineering, large language models}
}
Document
The End of History? Using a Proof Assistant to Replace Language Design with Library Design

Authors: Adam Chlipala, Benjamin Delaware, Samuel Duchovni, Jason Gross, Clément Pit-Claudel, Sorawit Suriyakarn, Peng Wang, and Katherine Ye

Published in: LIPIcs, Volume 71, 2nd Summit on Advances in Programming Languages (SNAPL 2017)


Abstract
Functionality of software systems has exploded in part because of advances in programming-language support for packaging reusable functionality as libraries. Developers benefit from the uniformity that comes of exposing many interfaces in the same language, as opposed to stringing together hodgepodges of command-line tools. Domain-specific languages may be viewed as an evolution of the power of reusable interfaces, when those interfaces become so flexible as to deserve to be called programming languages. However, common approaches to domain-specific languages give up many of the hard-won advantages of library-building in a rich common language, and even the traditional approach poses significant challenges in learning new APIs. We suggest that instead of continuing to develop new domain-specific languages, our community should embrace library-based ecosystems within very expressive languages that mix programming and theorem proving. Our prototype framework Fiat, a library for the Coq proof assistant, turns languages into easily comprehensible libraries via the key idea of modularizing functionality and performance away from each other, the former via macros that desugar into higher-order logic and the latter via optimization scripts that derive efficient code from logical programs.

Cite as

Adam Chlipala, Benjamin Delaware, Samuel Duchovni, Jason Gross, Clément Pit-Claudel, Sorawit Suriyakarn, Peng Wang, and Katherine Ye. The End of History? Using a Proof Assistant to Replace Language Design with Library Design. In 2nd Summit on Advances in Programming Languages (SNAPL 2017). Leibniz International Proceedings in Informatics (LIPIcs), Volume 71, pp. 3:1-3:15, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2017)


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@InProceedings{chlipala_et_al:LIPIcs.SNAPL.2017.3,
  author =	{Chlipala, Adam and Delaware, Benjamin and Duchovni, Samuel and Gross, Jason and Pit-Claudel, Cl\'{e}ment and Suriyakarn, Sorawit and Wang, Peng and Ye, Katherine},
  title =	{{The End of History? Using a Proof Assistant to Replace Language Design with Library Design}},
  booktitle =	{2nd Summit on Advances in Programming Languages (SNAPL 2017)},
  pages =	{3:1--3:15},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-032-3},
  ISSN =	{1868-8969},
  year =	{2017},
  volume =	{71},
  editor =	{Lerner, Benjamin S. and Bod{\'\i}k, Rastislav and Krishnamurthi, Shriram},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.SNAPL.2017.3},
  URN =		{urn:nbn:de:0030-drops-71233},
  doi =		{10.4230/LIPIcs.SNAPL.2017.3},
  annote =	{Keywords: Domain-specific languages, synthesis, verification, proof assistants, software development}
}
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