30 Search Results for "Gomez, Timothy"

Document
DOI: 10.4230/LIPIcs.SWAT.2026.3
Reachability with Restricted Reactions in Inhibitory Chemical Reaction Networks

Authors: Divya Bajaj, Bin Fu, Ryan Knobel, Austin Luchsinger, Aiden Massie, Pablo Santos, Ramiro Santos, Robert Schweller, Evan Tomai, and Tim Wylie

Published in: LIPIcs, Volume 370, 20th Scandinavian Symposium on Algorithm Theory (SWAT 2026)

Abstract
Chemical Reaction Networks (CRNs) are a well-established model of distributed computing characterized by quantities of molecular species that can transform or change through applications of reactions. A fundamental problem in CRNs is the reachability problem, which asks if an initial configuration of species can transition to a target configuration through an applicable sequence of reactions. It is well-known that the reachability problem in general CRNs was recently proven to be Ackermann-complete. However, if the CRN’s reactions are restricted in both power, such as only deleting species (deletion-only rules) or consuming and producing an equal number of species (volume-preserving rules), and size (unimolecular or bimolecular rules), then reachability falls below Ackermann-completeness, and is even solvable in polynomial time for deletion-only systems. In this paper, we investigate reachability under this set of restricted unimolecular and bimolecular reactions, but in the Priority-Inhibitory CRN and Inhibitory CRN models. These models extend a traditional CRN by allowing some reactions to be inhibited from firing in a configuration if certain species are present; the exact inhibition behavior varies between the models. We first show that reachability with Priority iCRNs mostly remains in P for deletion-only systems, but becomes NP-complete for one case. We then show that reachability with deletion-only reactions for iCRNs is mostly NP-complete, and PSPACE-complete even for (1,1)-size (general) reactions. We also provide FPT algorithms for solving most of the reachability problems for the iCRN model. Finally, we show reachability for CRNs with states is already NP-hard for the simplest deletion-only systems, and is PSPACE-complete even for (general) (1,1)-size reactions.
Cite as

Divya Bajaj, Bin Fu, Ryan Knobel, Austin Luchsinger, Aiden Massie, Pablo Santos, Ramiro Santos, Robert Schweller, Evan Tomai, and Tim Wylie. Reachability with Restricted Reactions in Inhibitory Chemical Reaction Networks. In 20th Scandinavian Symposium on Algorithm Theory (SWAT 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 370, pp. 3:1-3:18, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{bajaj_et_al:LIPIcs.SWAT.2026.3,
  author =	{Bajaj, Divya and Fu, Bin and Knobel, Ryan and Luchsinger, Austin and Massie, Aiden and Santos, Pablo and Santos, Ramiro and Schweller, Robert and Tomai, Evan and Wylie, Tim},
  title =	{{Reachability with Restricted Reactions in Inhibitory Chemical Reaction Networks}},
  booktitle =	{20th Scandinavian Symposium on Algorithm Theory (SWAT 2026)},
  pages =	{3:1--3:18},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-421-5},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{370},
  editor =	{Fraigniaud, Pierre},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.SWAT.2026.3},
  URN =		{urn:nbn:de:0030-drops-260399},
  doi =		{10.4230/LIPIcs.SWAT.2026.3},
  annote =	{Keywords: Chemical Reaction Networks, Vector Addition Systems, Petri-nets, Reachability, Inhibitors, Void Reactions}
}
Document
DOI: 10.4230/LIPIcs.SoCG.2026.78
Mapping Chemical Space: Topological Data Analysis of Chemical Latent Space with Mapper

Authors: Dhruv Meduri, Chuan-Shen Hu, Cong Shen, Kelin Xia, and Bei Wang

Published in: LIPIcs, Volume 367, 42nd International Symposium on Computational Geometry (SoCG 2026)

Abstract
The vast chemical space, encompassing virtually innumerable molecules and materials, presents both immense opportunities and significant challenges. The design and discovery of novel drugs and functional materials may be viewed as a search within this space; however, the sheer scale of potential candidates renders exhaustive exploration infeasible. To address this, we introduce Chemical Mapper, a framework that integrates topological data analysis with deep learning to enable the visual exploration and analysis of chemical latent spaces. At its core, Chemical Mapper employs mapper, a widely used tool in topological data analysis, to investigate the organizational principles of chemical latent spaces defined by molecular representations learned by geometric deep learning models. In doing so, Chemical Mapper not only highlights groups of molecular representations but also uncovers the relationships among them through linkages and branching structures. Our results show that Chemical Mapper reveals intrinsic patterns associated with molecular scaffolds, functional groups, and chemical properties, as well as the structural and functional evolutions of the molecules.
Cite as

Dhruv Meduri, Chuan-Shen Hu, Cong Shen, Kelin Xia, and Bei Wang. Mapping Chemical Space: Topological Data Analysis of Chemical Latent Space with Mapper. In 42nd International Symposium on Computational Geometry (SoCG 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 367, pp. 78:1-78:20, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{meduri_et_al:LIPIcs.SoCG.2026.78,
  author =	{Meduri, Dhruv and Hu, Chuan-Shen and Shen, Cong and Xia, Kelin and Wang, Bei},
  title =	{{Mapping Chemical Space: Topological Data Analysis of Chemical Latent Space with Mapper}},
  booktitle =	{42nd International Symposium on Computational Geometry (SoCG 2026)},
  pages =	{78:1--78:20},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-418-5},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{367},
  editor =	{Ahn, Hee-Kap and Hoffmann, Michael and Nayyeri, Amir},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.SoCG.2026.78},
  URN =		{urn:nbn:de:0030-drops-258854},
  doi =		{10.4230/LIPIcs.SoCG.2026.78},
  annote =	{Keywords: Practice of computational topology, topological data analysis, applications in chemistry, mapper algorithm, high-dimensional data analysis, chemical spaces, geometric deep learning, latent space geometry}
}
Document
DOI: 10.4230/LIPIcs.SoCG.2026.44
Tilt Automata: Gathering Particles with Uniform External Control

Authors: Sándor P. Fekete, Jonas Friemel, Peter Kramer, Jan-Marc Reinhardt, Christian Rieck, and Christian Scheffer

Published in: LIPIcs, Volume 367, 42nd International Symposium on Computational Geometry (SoCG 2026)

Abstract
Motivated by targeted drug delivery, we investigate the gathering of particles in the full tilt model of externally controlled motion planning: A set of particles is located at the tiles of a polyomino with all particles reacting uniformly to an external force by moving as far as possible in one of the four axis-parallel directions until they hit the boundary. The goal is to choose a sequence of directions that moves all particles to a common position. Our results include a polynomial-time algorithm for gathering in a completely filled polyomino as well as hardness reductions for approximating shortest gathering sequences and for determining whether the particles in a partially filled polyomino can be gathered. We pay special attention to the impact of restricted geometry, particularly polyominoes without holes. As a corollary, we make progress on an open question from [Balanza-Martinez et al., SODA 2020] by showing that deciding whether a given position can be occupied remains NP-hard in polyominoes without holes. Our results build on a connection we establish between tilt models and the theory of synchronizing automata.
Cite as

Sándor P. Fekete, Jonas Friemel, Peter Kramer, Jan-Marc Reinhardt, Christian Rieck, and Christian Scheffer. Tilt Automata: Gathering Particles with Uniform External Control. In 42nd International Symposium on Computational Geometry (SoCG 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 367, pp. 44:1-44:19, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{fekete_et_al:LIPIcs.SoCG.2026.44,
  author =	{Fekete, S\'{a}ndor P. and Friemel, Jonas and Kramer, Peter and Reinhardt, Jan-Marc and Rieck, Christian and Scheffer, Christian},
  title =	{{Tilt Automata: Gathering Particles with Uniform External Control}},
  booktitle =	{42nd International Symposium on Computational Geometry (SoCG 2026)},
  pages =	{44:1--44:19},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-418-5},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{367},
  editor =	{Ahn, Hee-Kap and Hoffmann, Michael and Nayyeri, Amir},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.SoCG.2026.44},
  URN =		{urn:nbn:de:0030-drops-258508},
  doi =		{10.4230/LIPIcs.SoCG.2026.44},
  annote =	{Keywords: Uniform control, gathering, full tilt, polyominoes, synchronizing automata}
}
Document
DOI: 10.4230/LIPIcs.FUN.2026.27
Completing the Complexity Classification of 2-Solo Chess: Knights and Kings Are Hard

Authors: Kolja Kühn and Wendy Yi

Published in: LIPIcs, Volume 366, 13th International Conference on Fun with Algorithms (FUN 2026)

Abstract
We extend the study of the 2-Solo Chess problem which was first introduced by Aravind, Misra, and Mittal in 2022. 2-Solo Chess is a single-player variant of chess in which the player must clear the board via captures such that only one piece remains, with each piece capturing at most twice. It is known that the problem is solvable in polynomial time for instances containing only pawns, while it becomes NP-complete for instances restricted to rooks, bishops, or queens. In this work, we complete the complexity classification by proving that 2-Solo Chess is NP-complete if the instance contains only knights or only kings.
Cite as

Kolja Kühn and Wendy Yi. Completing the Complexity Classification of 2-Solo Chess: Knights and Kings Are Hard. In 13th International Conference on Fun with Algorithms (FUN 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 366, pp. 27:1-27:21, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{kuhn_et_al:LIPIcs.FUN.2026.27,
  author =	{K\"{u}hn, Kolja and Yi, Wendy},
  title =	{{Completing the Complexity Classification of 2-Solo Chess: Knights and Kings Are Hard}},
  booktitle =	{13th International Conference on Fun with Algorithms (FUN 2026)},
  pages =	{27:1--27:21},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-417-8},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{366},
  editor =	{Iacono, John},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.FUN.2026.27},
  URN =		{urn:nbn:de:0030-drops-257464},
  doi =		{10.4230/LIPIcs.FUN.2026.27},
  annote =	{Keywords: Solo chess, puzzle games, board games, NP-completeness}
}
Document
DOI: 10.4230/OASIcs.NINeS.2026.24
SwiftQueue: Optimizing Low-Latency Applications with Swift Packet Queuing

Authors: Siddhant Ray, Xi Jiang, Jack Luo, Nick Feamster, and Junchen Jiang

Published in: OASIcs, Volume 139, 1st New Ideas in Networked Systems (NINeS 2026)

Abstract
Low Latency, Low Loss, and Scalable Throughput (L4S), as an emerging router-queue management technique, has seen steady deployment in the industry. An L4S-enabled router assigns each packet to the queue based on the packet header marking. Currently, L4S employs per-flow queue selection, i.e., all packets of a flow are marked the same way and thus use the same queues, even though each packet is marked separately. However, this may hurt tail latency and latency-sensitive applications because transient congestion and queue buildups may only affect a fraction of packets in a flow. We present SwiftQueue, a new L4S queue-selection strategy in which a sender uses a novel per-packet latency predictor to pinpoint which packets likely have latency spikes or drops. The insight is that many packet-level latency variations result from complex interactions among recent packets at shared router queues. Yet, these intricate packet-level latency patterns are hard to learn efficiently by traditional models. Instead, SwiftQueue uses a custom Transformer, which is well-studied for its expressiveness on sequential patterns, to predict the next packet’s latency based on the latencies of recently received ACKs. Based on the predicted latency of each outgoing packet, SwiftQueue’s sender dynamically marks the L4S packet header to assign packets to potentially different queues, even within the same flow. Using real network traces, we show that SwiftQueue is 45-65% more accurate in predicting latency and its variations than state-of-art methods. Based on its latency prediction, SwiftQueue reduces the tail latency for L4S-enabled flows by 36-45%, compared with the existing L4S queue-selection method.
Cite as

Siddhant Ray, Xi Jiang, Jack Luo, Nick Feamster, and Junchen Jiang. SwiftQueue: Optimizing Low-Latency Applications with Swift Packet Queuing. In 1st New Ideas in Networked Systems (NINeS 2026). Open Access Series in Informatics (OASIcs), Volume 139, pp. 24:1-24:29, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{ray_et_al:OASIcs.NINeS.2026.24,
  author =	{Ray, Siddhant and Jiang, Xi and Luo, Jack and Feamster, Nick and Jiang, Junchen},
  title =	{{SwiftQueue: Optimizing Low-Latency Applications with Swift Packet Queuing}},
  booktitle =	{1st New Ideas in Networked Systems (NINeS 2026)},
  pages =	{24:1--24:29},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-414-7},
  ISSN =	{2190-6807},
  year =	{2026},
  volume =	{139},
  editor =	{Argyraki, Katerina and Panda, Aurojit},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.NINeS.2026.24},
  URN =		{urn:nbn:de:0030-drops-256093},
  doi =		{10.4230/OASIcs.NINeS.2026.24},
  annote =	{Keywords: Latency prediction, L4S Queue Management}
}
Document
DOI: 10.4230/LIPIcs.ITCS.2026.14
General Computation Using Slidable Tiles with Deterministic Global Forces

Authors: Alberto Avila-Jimenez, David Barreda, Sarah-Laurie Evans, Austin Luchsinger, Aiden Massie, Robert Schweller, Evan Tomai, and Tim Wylie

Published in: LIPIcs, Volume 362, 17th Innovations in Theoretical Computer Science Conference (ITCS 2026)

Abstract
We study the computational power of the Full-Tilt model of motion planning, where slidable polyominos are moved maximally around a board by way of a sequence of directional "tilts." We focus on the deterministic scenario in which the tilts constitute a repeated clockwise rotation. We show that general-purpose computation is possible within this framework by providing a direct and efficient simulation of space-bounded Turing machines in which one computational step of the machine is simulated per O(1) rotations. We further show that the initial tape of the machine can be programmed by an initial tilt-sequence preceding the rotations. This result immediately implies new PSPACE-completeness results for the well-studied problems of occupancy (deciding if a given board location can be occupied by a tile), vacancy (deciding if a location can be emptied), relocation (deciding if a tile can be moved from one location to another), and reconfiguration (can a given board configuration be reconfigured into a second given configuration) that hold even for deterministically repeating tilt cycles such as rotations. All of our PSPACE-completeness results hold even when there is only a single domino in the system beyond singleton tiles. Following, we show that these results work in the Single-Step tilt model for larger constant cycles. We then investigate computational efficiency by showing a modification to implement a two-tape Turing machine in the Full-Tilt model and Systolic Arrays in the Single-Step model. Finally, we show a cyclic implementation for tilt-efficient Threshold Circuits.
Cite as

Alberto Avila-Jimenez, David Barreda, Sarah-Laurie Evans, Austin Luchsinger, Aiden Massie, Robert Schweller, Evan Tomai, and Tim Wylie. General Computation Using Slidable Tiles with Deterministic Global Forces. In 17th Innovations in Theoretical Computer Science Conference (ITCS 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 362, pp. 14:1-14:25, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{avilajimenez_et_al:LIPIcs.ITCS.2026.14,
  author =	{Avila-Jimenez, Alberto and Barreda, David and Evans, Sarah-Laurie and Luchsinger, Austin and Massie, Aiden and Schweller, Robert and Tomai, Evan and Wylie, Tim},
  title =	{{General Computation Using Slidable Tiles with Deterministic Global Forces}},
  booktitle =	{17th Innovations in Theoretical Computer Science Conference (ITCS 2026)},
  pages =	{14:1--14:25},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-410-9},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{362},
  editor =	{Saraf, Shubhangi},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ITCS.2026.14},
  URN =		{urn:nbn:de:0030-drops-253019},
  doi =		{10.4230/LIPIcs.ITCS.2026.14},
  annote =	{Keywords: motion planning, global control, external forces, deterministic computation, occupancy, vacancy}
}
Document
Research
DOI: 10.4230/TGDK.3.3.4
Mining Inter-Document Argument Structures in Scientific Papers for an Argument Web

Authors: Florian Ruosch, Cristina Sarasua, and Abraham Bernstein

Published in: TGDK, Volume 3, Issue 3 (2025). Transactions on Graph Data and Knowledge, Volume 3, Issue 3

Abstract
In Argument Mining, predicting argumentative relations between texts (or spans) remains one of the most challenging aspects, even more so in the cross-document setting. This paper makes three key contributions to advance research in this domain. We first extend an existing dataset, the Sci-Arg corpus, by annotating it with explicit inter-document argumentative relations, thereby allowing arguments to be distributed over several documents forming an Argument Web; these new annotations are published using Semantic Web technologies (RDF, OWL). Second, we explore and evaluate three automated approaches for predicting these inter-document argumentative relations, establishing critical baselines on the new dataset. We find that a simple classifier based on discourse indicators with access to context outperforms neural methods. Third, we conduct a comparative analysis of these approaches for both intra- and inter-document settings, identifying statistically significant differences in results that indicate the necessity of distinguishing between these two scenarios. Our findings highlight significant challenges in this complex domain and open crucial avenues for future research on the Argument Web of Science, particularly for those interested in leveraging Semantic Web technologies and knowledge graphs to understand scholarly discourse. With this, we provide the first stepping stones in the form of a benchmark dataset, three baseline methods, and an initial analysis for a systematic exploration of this field relevant to the Web of Data and Science.
Cite as

Florian Ruosch, Cristina Sarasua, and Abraham Bernstein. Mining Inter-Document Argument Structures in Scientific Papers for an Argument Web. In Transactions on Graph Data and Knowledge (TGDK), Volume 3, Issue 3, pp. 4:1-4:33, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@Article{ruosch_et_al:TGDK.3.3.4,
  author =	{Ruosch, Florian and Sarasua, Cristina and Bernstein, Abraham},
  title =	{{Mining Inter-Document Argument Structures in Scientific Papers for an Argument Web}},
  journal =	{Transactions on Graph Data and Knowledge},
  pages =	{4:1--4:33},
  ISSN =	{2942-7517},
  year =	{2025},
  volume =	{3},
  number =	{3},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/TGDK.3.3.4},
  URN =		{urn:nbn:de:0030-drops-252159},
  doi =		{10.4230/TGDK.3.3.4},
  annote =	{Keywords: Argument Mining, Large Language Models, Knowledge Graphs, Link Prediction}
}
Document
Invited Paper
DOI: 10.4230/OASIcs.RW.2024/2025.1
Rule-Based Knowledge Graph Completion (Invited Paper)

Authors: Patrick Betz, Christian Meilicke, and Heiner Stuckenschmidt

Published in: OASIcs, Volume 138, Joint Proceedings of the 20th and 21st Reasoning Web Summer Schools (RW 2024 & RW 2025)

Abstract
The field of knowledge graph completion is concerned with augmenting knowledge graphs with missing information. Symbolic rule-based approaches are not only efficient and interpretable but also competitive with embedding-based methods in regard to predictive quality. Rule-based knowledge graph completion can be separated into two stages, the learning stage and the application stage, which are both individually challenging. In the learning stage, horn rules are mined from a given knowledge graph. Given the vast size of the space of all possible rules, the mining approach must select relevant rules effectively. In the application stage, the mined rules are used to make new predictions which are assigned with plausibility scores. These scores need to be set by aggregating individual confidence values of rules that have the same consequence. This tutorial covers the fundamental aspects required to build a symbolic rule-based approach for knowledge graph completion. It will discuss the different rule types, mining strategies, and how to effectively apply the rules in different scenarios. Finally, we discuss practical examples for rule application by using the Python-based PyClause library.
Cite as

Patrick Betz, Christian Meilicke, and Heiner Stuckenschmidt. Rule-Based Knowledge Graph Completion (Invited Paper). In Joint Proceedings of the 20th and 21st Reasoning Web Summer Schools (RW 2024 & RW 2025). Open Access Series in Informatics (OASIcs), Volume 138, pp. 1:1-1:45, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{betz_et_al:OASIcs.RW.2024/2025.1,
  author =	{Betz, Patrick and Meilicke, Christian and Stuckenschmidt, Heiner},
  title =	{{Rule-Based Knowledge Graph Completion}},
  booktitle =	{Joint Proceedings of the 20th and 21st Reasoning Web Summer Schools (RW 2024 \& RW 2025)},
  pages =	{1:1--1:45},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-405-5},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{138},
  editor =	{Artale, Alessandro and Bienvenu, Meghyn and Garc{\'\i}a, Yazm{\'\i}n Ib\'{a}\~{n}ez and Murlak, Filip},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.RW.2024/2025.1},
  URN =		{urn:nbn:de:0030-drops-250461},
  doi =		{10.4230/OASIcs.RW.2024/2025.1},
  annote =	{Keywords: Knowledge Graph Completion, Rule Learning, Symbolic AI}
}
Document
DOI: 10.4230/LIPIcs.ISAAC.2025.7
Polynomial Equivalence of Extended Chemical Reaction Models

Authors: Divya Bajaj, Jose-Luis Castellanos, Ryan Knobel, Austin Luchsinger, Aiden Massie, Adrian Salinas, Pablo Santos, Ramiro Santos, Robert Schweller, and Tim Wylie

Published in: LIPIcs, Volume 359, 36th International Symposium on Algorithms and Computation (ISAAC 2025)

Abstract
The ability to detect whether a species (or dimension) is zero in Chemical Reaction Networks (CRN), Vector Addition Systems, or Petri Nets is known to increase the power of these models - making them capable of universal computation. While this ability may appear in many forms, such as extending the models to allow transitions to be inhibited, prioritized, or synchronized, we present an extension that directly performs this zero checking. We introduce a new void genesis CRN variant with a simple design that merely increments the count of a specific species when any other species' count goes to zero. As with previous extensions, we show that the model is Turing Universal. We then analyze several other studied CRN variants and show that they are all equivalent through a polynomial simulation with the void genesis model, which does not merely follow from Turing-universality. Thus, inhibitor species, reactions that occur at different rates, being allowed to run reactions in parallel, or even being allowed to continually add more volume to the CRN, does not add additional simulation power beyond simply detecting if a species count becomes zero.
Cite as

Divya Bajaj, Jose-Luis Castellanos, Ryan Knobel, Austin Luchsinger, Aiden Massie, Adrian Salinas, Pablo Santos, Ramiro Santos, Robert Schweller, and Tim Wylie. Polynomial Equivalence of Extended Chemical Reaction Models. In 36th International Symposium on Algorithms and Computation (ISAAC 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 359, pp. 7:1-7:21, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{bajaj_et_al:LIPIcs.ISAAC.2025.7,
  author =	{Bajaj, Divya and Castellanos, Jose-Luis and Knobel, Ryan and Luchsinger, Austin and Massie, Aiden and Salinas, Adrian and Santos, Pablo and Santos, Ramiro and Schweller, Robert and Wylie, Tim},
  title =	{{Polynomial Equivalence of Extended Chemical Reaction Models}},
  booktitle =	{36th International Symposium on Algorithms and Computation (ISAAC 2025)},
  pages =	{7:1--7:21},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-408-6},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{359},
  editor =	{Chen, Ho-Lin and Hon, Wing-Kai and Tsai, Meng-Tsung},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ISAAC.2025.7},
  URN =		{urn:nbn:de:0030-drops-249158},
  doi =		{10.4230/LIPIcs.ISAAC.2025.7},
  annote =	{Keywords: Chemical Reaction Networks, Simulations, Petri-nets, Vector Addition Systems, Bi-simulation, Turing-universality, Inhibitors}
}
Document
DOI: 10.4230/OASIcs.SpaceCHI.2025.26
Movement in Low Gravity (MoLo) – LUNA: Biomechanical Modelling to Mitigate Lunar Surface Operation Risks

Authors: David Andrew Green

Published in: OASIcs, Volume 130, Advancing Human-Computer Interaction for Space Exploration (SpaceCHI 2025)

Abstract
The Artemis programme seeks to develop and test concepts, hardware and approaches to support long term habitation of the Lunar surface, and future missions to Mars. In preparation for the Artemis missions determination of tasks to be performed, the functional requirements of such tasks and as mission duration extends whether physiological deconditioning becomes functionally significant, compromising the crew member’s ability to perform critical tasks on the surface, and/or upon return to earth [MoLo-LUNA – leveraging the Molo programme (and several other activities) - could become a key supporting activity for LUNA incl. validation of the Puppeteer offloading system itself via creation of a complementary MoLo-LUNA-LAB. Furthermore, the MoLo-LUNA programme could become a key facilitator of simulator suit instrumentation/definition, broader astronaut training activities and mission architecture development – including Artemis mission simulations. By employing a Puppeteer system external to the LUNA chamber hall it will optimise utilisation and cost-effectiveness of LUNA, and as such represents a critical service to future LUNA stakeholders. Furthermore, MoLo-LUNA would generate a unique data set that can be leveraged to predict de-conditioning on the Lunar surface - and thereby optimise functionality, and minimise mission risk – including informing the need for, and prescription of exercise countermeasures on the Lunar Surface and in transit. Thus, MoLo-LUNA offers a unique opportunity to place LUNA, and ESA as a key ongoing provider of evidence to define, optimise and support crew Artemis surface missions.
Cite as

David Andrew Green. Movement in Low Gravity (MoLo) – LUNA: Biomechanical Modelling to Mitigate Lunar Surface Operation Risks. In Advancing Human-Computer Interaction for Space Exploration (SpaceCHI 2025). Open Access Series in Informatics (OASIcs), Volume 130, pp. 26:1-26:11, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{green:OASIcs.SpaceCHI.2025.26,
  author =	{Green, David Andrew},
  title =	{{Movement in Low Gravity (MoLo) – LUNA: Biomechanical Modelling to Mitigate Lunar Surface Operation Risks}},
  booktitle =	{Advancing Human-Computer Interaction for Space Exploration (SpaceCHI 2025)},
  pages =	{26:1--26:11},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-384-3},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{130},
  editor =	{Bensch, Leonie and Nilsson, Tommy and Nisser, Martin and Pataranutaporn, Pat and Schmidt, Albrecht and Sumini, Valentina},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.SpaceCHI.2025.26},
  URN =		{urn:nbn:de:0030-drops-240166},
  doi =		{10.4230/OASIcs.SpaceCHI.2025.26},
  annote =	{Keywords: Locomotion, hypogravity, modelling, Lunar}
}
Document
DOI: 10.4230/LIPIcs.DNA.31.1
Algorithmic Hardness of the Partition Function for Nucleic Acid Strands

Authors: Gwendal Ducloz, Ahmed Shalaby, and Damien Woods

Published in: LIPIcs, Volume 347, 31st International Conference on DNA Computing and Molecular Programming (DNA 31) (2025)

Abstract
To understand and engineer biological and artificial nucleic acid systems, algorithms are employed for prediction of secondary structures at thermodynamic equilibrium. Dynamic programming algorithms are used to compute the most favoured, or Minimum Free Energy (MFE), structure, and the Partition Function (PF) - a tool for assigning a probability to any structure. However, in some situations, such as when there are large numbers of strands, or pseudoknotted systems, NP-hardness results show that such algorithms are unlikely, but only for MFE. Curiously, algorithmic hardness results were not shown for PF, leaving two open questions on the complexity of PF for multiple strands and single strands with pseudoknots. The challenge is that while the MFE problem cares only about one, or a few structures, PF is a summation over the entire secondary structure space, giving theorists the vibe that computing PF should not only be as hard as MFE, but should be even harder. We answer both questions. First, we show that computing PF is #P-hard for systems with an unbounded number of strands, answering a question of Condon Hajiaghayi, and Thachuk [DNA27]. Second, for even a single strand, but allowing pseudoknots, we find that PF is #P-hard. Our proof relies on a novel magnification trick that leads to a tightly-woven set of reductions between five key thermodynamic problems: MFE, PF, their decision versions, and #SSEL that counts structures of a given energy. Our reductions show these five problems are fundamentally related for any energy model amenable to magnification. That general classification clarifies the mathematical landscape of nucleic acid energy models and yields several open questions.
Cite as

Gwendal Ducloz, Ahmed Shalaby, and Damien Woods. Algorithmic Hardness of the Partition Function for Nucleic Acid Strands. In 31st International Conference on DNA Computing and Molecular Programming (DNA 31). Leibniz International Proceedings in Informatics (LIPIcs), Volume 347, pp. 1:1-1:23, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{ducloz_et_al:LIPIcs.DNA.31.1,
  author =	{Ducloz, Gwendal and Shalaby, Ahmed and Woods, Damien},
  title =	{{Algorithmic Hardness of the Partition Function for Nucleic Acid Strands}},
  booktitle =	{31st International Conference on DNA Computing and Molecular Programming (DNA 31)},
  pages =	{1:1--1:23},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-399-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{347},
  editor =	{Schaeffer, Josie and Zhang, Fei},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.DNA.31.1},
  URN =		{urn:nbn:de:0030-drops-238504},
  doi =		{10.4230/LIPIcs.DNA.31.1},
  annote =	{Keywords: Partition function, minimum free energy, nucleic acid, DNA, RNA, secondary structure, computational complexity, #P-hardness}
}
Document
DOI: 10.4230/LIPIcs.DNA.31.3
Reachability in Deletion-Only Chemical Reaction Networks

Authors: Bin Fu, Timothy Gomez, Ryan Knobel, Austin Luchsinger, Aiden Massie, Marco Rodriguez, Adrian Salinas, Robert Schweller, and Tim Wylie

Published in: LIPIcs, Volume 347, 31st International Conference on DNA Computing and Molecular Programming (DNA 31) (2025)

Abstract
For general discrete Chemical Reaction Networks (CRNs), the fundamental problem of reachability - the question of whether a target configuration can be produced from a given initial configuration - was recently shown to be Ackermann-complete. However, many open questions remain about which features of the CRN model drive this complexity. We study a restricted class of CRNs with void rules, reactions that only decrease species counts. We further examine this regime in the motivated model of step CRNs, which allow additional species to be introduced in discrete stages. With and without steps, we characterize the complexity of the reachability problem for CRNs with void rules. We show that, without steps, reachability remains polynomial-time solvable for bimolecular systems but becomes NP-complete for larger reactions. Conversely, with just a single step, reachability becomes NP-complete even for bimolecular systems. Our results provide a nearly complete classification of void-rule reachability problems into tractable and intractable cases, with only a single exception.
Cite as

Bin Fu, Timothy Gomez, Ryan Knobel, Austin Luchsinger, Aiden Massie, Marco Rodriguez, Adrian Salinas, Robert Schweller, and Tim Wylie. Reachability in Deletion-Only Chemical Reaction Networks. In 31st International Conference on DNA Computing and Molecular Programming (DNA 31). Leibniz International Proceedings in Informatics (LIPIcs), Volume 347, pp. 3:1-3:21, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{fu_et_al:LIPIcs.DNA.31.3,
  author =	{Fu, Bin and Gomez, Timothy and Knobel, Ryan and Luchsinger, Austin and Massie, Aiden and Rodriguez, Marco and Salinas, Adrian and Schweller, Robert and Wylie, Tim},
  title =	{{Reachability in Deletion-Only Chemical Reaction Networks}},
  booktitle =	{31st International Conference on DNA Computing and Molecular Programming (DNA 31)},
  pages =	{3:1--3:21},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-399-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{347},
  editor =	{Schaeffer, Josie and Zhang, Fei},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.DNA.31.3},
  URN =		{urn:nbn:de:0030-drops-238521},
  doi =		{10.4230/LIPIcs.DNA.31.3},
  annote =	{Keywords: CRN, Chemical Reaction Network, Reachability, Void Reactions}
}
Document
DOI: 10.4230/LIPIcs.CONCUR.2025.26
Optimal Concolic Dynamic Partial Order Reduction

Authors: Mohammad Hossein Khoshechin Jorshari, Michalis Kokologiannakis, Rupak Majumdar, and Srinidhi Nagendra

Published in: LIPIcs, Volume 348, 36th International Conference on Concurrency Theory (CONCUR 2025)

Abstract
Stateless model checking (SMC) software implementations requires exploring both concurrency- and data nondeterminism. Unfortunately, most SMC algorithms focus on efficient exploration of concurrency nondeterminism, thereby neglecting an important source of bugs. We present ConDpor, an SMC algorithm for unmodified Java programs that combines optimal dynamic partial order reduction (DPOR) for concurrency nondeterminism, with concolic execution for data nondeterminism. ConDpor is sound, complete, optimal, and parametric w.r.t. the memory consistency model. Our experiments confirm that ConDpor is exponentially faster than DPOR with small-domain enumeration. Overall, ConDpor opens the door for efficient exploration of concurrent programs with data nondeterminism.
Cite as

Mohammad Hossein Khoshechin Jorshari, Michalis Kokologiannakis, Rupak Majumdar, and Srinidhi Nagendra. Optimal Concolic Dynamic Partial Order Reduction. In 36th International Conference on Concurrency Theory (CONCUR 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 348, pp. 26:1-26:22, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{khoshechinjorshari_et_al:LIPIcs.CONCUR.2025.26,
  author =	{Khoshechin Jorshari, Mohammad Hossein and Kokologiannakis, Michalis and Majumdar, Rupak and Nagendra, Srinidhi},
  title =	{{Optimal Concolic Dynamic Partial Order Reduction}},
  booktitle =	{36th International Conference on Concurrency Theory (CONCUR 2025)},
  pages =	{26:1--26:22},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-389-8},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{348},
  editor =	{Bouyer, Patricia and van de Pol, Jaco},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.CONCUR.2025.26},
  URN =		{urn:nbn:de:0030-drops-239765},
  doi =		{10.4230/LIPIcs.CONCUR.2025.26},
  annote =	{Keywords: Stateless model checking, dynamic symbolic execution}
}
Document
DOI: 10.4230/LIPIcs.GIScience.2025.14
Guiding Geospatial Analysis Processes in Dealing with Modifiable Areal Unit Problems

Authors: Guoray Cai and Yue Hao

Published in: LIPIcs, Volume 346, 13th International Conference on Geographic Information Science (GIScience 2025)

Abstract
Geospatial analysis has been widely applied in different domains for critical decision making. However, the results of spatial analysis are often plagued with uncertainties due to measurement errors, choice of data representations, and unintended transformation artifacts. A well known example of such problems is the Modifiable Areal Unit Problem (MAUP) which has well documented effects on the outcome of spatial analysis on area-aggregated data. Existing methods for addressing the effects of MAUP are limited, are technically complex, and are often inaccessible to practitioners. As a result, analysts tend to ignore the effects of MAUP in practice due to lack of expertise, high cognitive loads, and resource limitations. To address these challenges, this paper proposes a machine-guidance approach to augment the analyst’s capacity in mitigating the effect of MAUP. Based on an analysis of practical challenges faced by human analysts, we identified multiple opportunities for the machine to guide the analysts by alerting to the rise of MAUP, assessing the impact of MAUP, choosing mitigation methods, and generating visual guidance messages using GIS functions and tools. For each of the opportunities, we characterize the behavior patterns and the underlying guidance strategies that generate the behavior. We illustrate the behavior of machine guidance using a hotspot analysis scenario in the context of crime policing, where MAUP has strong effects on the patterns of crime hotspots. Finally, we describe the computational framework used to build a prototype guidance system and identify a number of research questions to be addressed. We conclude by discussing how the machine guidance approach could be an answer to some of the toughest problems in geospatial analysis.
Cite as

Guoray Cai and Yue Hao. Guiding Geospatial Analysis Processes in Dealing with Modifiable Areal Unit Problems. In 13th International Conference on Geographic Information Science (GIScience 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 346, pp. 14:1-14:18, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{cai_et_al:LIPIcs.GIScience.2025.14,
  author =	{Cai, Guoray and Hao, Yue},
  title =	{{Guiding Geospatial Analysis Processes in Dealing with Modifiable Areal Unit Problems}},
  booktitle =	{13th International Conference on Geographic Information Science (GIScience 2025)},
  pages =	{14:1--14:18},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-378-2},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{346},
  editor =	{Sila-Nowicka, Katarzyna and Moore, Antoni and O'Sullivan, David and Adams, Benjamin and Gahegan, Mark},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.GIScience.2025.14},
  URN =		{urn:nbn:de:0030-drops-238433},
  doi =		{10.4230/LIPIcs.GIScience.2025.14},
  annote =	{Keywords: Machine Guidance, Geo-Spatial Analysis, Modifiable Areal Unit Problem (MAUP)}
}
Document
Track A: Algorithms, Complexity and Games
DOI: 10.4230/LIPIcs.ICALP.2025.74
Drainability and Fillability of Polyominoes in Diverse Models of Global Control

Authors: Sándor P. Fekete, Peter Kramer, Jan-Marc Reinhardt, Christian Rieck, and Christian Scheffer

Published in: LIPIcs, Volume 334, 52nd International Colloquium on Automata, Languages, and Programming (ICALP 2025)

Abstract
Tilt models offer intuitive and clean definitions of complex systems in which particles are influenced by global control commands. Despite a wide range of applications, there has been almost no theoretical investigation into the associated issues of filling and draining geometric environments. This is partly because a globally controlled system (i.e., passive matter) exhibits highly complex behavior that cannot be locally restricted. Thus, there is a strong need for theoretical studies that investigate these models both (1) in terms of relative power to each other, and (2) from a complexity theory perspective. In this work, we provide (1) general tools for comparing and contrasting different models of global control, and (2) both complexity and algorithmic results on filling and draining.
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Sándor P. Fekete, Peter Kramer, Jan-Marc Reinhardt, Christian Rieck, and Christian Scheffer. Drainability and Fillability of Polyominoes in Diverse Models of Global Control. In 52nd International Colloquium on Automata, Languages, and Programming (ICALP 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 334, pp. 74:1-74:19, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{fekete_et_al:LIPIcs.ICALP.2025.74,
  author =	{Fekete, S\'{a}ndor P. and Kramer, Peter and Reinhardt, Jan-Marc and Rieck, Christian and Scheffer, Christian},
  title =	{{Drainability and Fillability of Polyominoes in Diverse Models of Global Control}},
  booktitle =	{52nd International Colloquium on Automata, Languages, and Programming (ICALP 2025)},
  pages =	{74:1--74:19},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-372-0},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{334},
  editor =	{Censor-Hillel, Keren and Grandoni, Fabrizio and Ouaknine, Jo\"{e}l and Puppis, Gabriele},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ICALP.2025.74},
  URN =		{urn:nbn:de:0030-drops-234518},
  doi =		{10.4230/LIPIcs.ICALP.2025.74},
  annote =	{Keywords: Global control, full Tilt, single Tilt, Fillability, Drainability, Polyominoes, Complexity}
}
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