14 Search Results for "Punzi, Giulia"


Document
Maximizing Diversity in (Near-)Median String Selection

Authors: Diptarka Chakraborty, Rudrayan Kundu, Nidhi Purohit, and Aravinda Kanchana Ruwanpathirana

Published in: LIPIcs, Volume 369, 37th Annual Symposium on Combinatorial Pattern Matching (CPM 2026)


Abstract
Given a set of strings over a specified alphabet, identifying a median or consensus string that minimizes the total distance to all input strings is a fundamental data aggregation problem. When the Hamming distance is considered as the underlying metric, this problem has extensive applications, ranging from bioinformatics to pattern recognition. However, modern applications often require the generation of multiple (near-)optimal yet diverse median strings to enhance flexibility and robustness in decision-making. In this study, we address this need by focusing on two prominent diversity measures: sum dispersion and min dispersion. We first introduce an exact algorithm for the diameter variant of the problem, which identifies pairs of near-optimal medians that are maximally diverse. Subsequently, we propose a (1-ε)-approximation algorithm (for any ε > 0) for sum dispersion, as well as a bi-criteria approximation algorithm for the more challenging min dispersion case, allowing the generation of multiple (more than two) diverse near-optimal Hamming medians. Our approach primarily leverages structural insights into the Hamming median space and also draws on techniques from error-correcting code construction to establish these results.

Cite as

Diptarka Chakraborty, Rudrayan Kundu, Nidhi Purohit, and Aravinda Kanchana Ruwanpathirana. Maximizing Diversity in (Near-)Median String Selection. In 37th Annual Symposium on Combinatorial Pattern Matching (CPM 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 369, pp. 12:1-12:15, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)


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@InProceedings{chakraborty_et_al:LIPIcs.CPM.2026.12,
  author =	{Chakraborty, Diptarka and Kundu, Rudrayan and Purohit, Nidhi and Ruwanpathirana, Aravinda Kanchana},
  title =	{{Maximizing Diversity in (Near-)Median String Selection}},
  booktitle =	{37th Annual Symposium on Combinatorial Pattern Matching (CPM 2026)},
  pages =	{12:1--12:15},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-420-8},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{369},
  editor =	{Bille, Philip and Prezza, Nicola},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.CPM.2026.12},
  URN =		{urn:nbn:de:0030-drops-259382},
  doi =		{10.4230/LIPIcs.CPM.2026.12},
  annote =	{Keywords: Diversity maximization, Hamming median, diameter, dispersion, approximation algorithms}
}
Document
Hardness Results on Characteristics for Elastic-Degenerate Strings

Authors: Dominik Köppl and Jannik Olbrich

Published in: LIPIcs, Volume 369, 37th Annual Symposium on Combinatorial Pattern Matching (CPM 2026)


Abstract
Generalizations of plain strings have been proposed as a compact way to represent a collection of nearly identical sequences or to express uncertainty at specific text positions by enumerating all possibilities. While a plain string stores a character at each of its positions, generalizations consider a set of characters (indeterminate strings), a set of strings of equal length (generalized degenerate strings, or shortly GD strings), or a set of strings of arbitrary lengths (elastic-degenerate strings, or shortly ED strings). These generalizations are of importance to compactly represent such type of data, and find applications in bioinformatics for representing and maintaining a set of genetic sequences of the same taxonomy or a multiple sequence alignment. To be of use, attention has been drawn to answering various query types such as pattern matching or measuring similarity of ED strings by generalizing techniques known to plain strings. However, for some types of queries, it has been shown that a generalization of a polynomial-time solvable query on classic strings becomes NP-hard on ED strings, e.g. [Russo et al., 2022]. In that light, we wonder about other types of queries that are of particular interest to bioinformatics: unique substrings, absent words, anti-powers, longest previous factors, and Lempel-Ziv-like compression schemes. While we obtain a polynomial time algorithm for a variation of longest previous factors, we show that all other problems are NP-hard to compute, some of them even under the restriction that the input can be modeled as an indeterminate or GD string.

Cite as

Dominik Köppl and Jannik Olbrich. Hardness Results on Characteristics for Elastic-Degenerate Strings. In 37th Annual Symposium on Combinatorial Pattern Matching (CPM 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 369, pp. 14:1-14:25, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)


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@InProceedings{koppl_et_al:LIPIcs.CPM.2026.14,
  author =	{K\"{o}ppl, Dominik and Olbrich, Jannik},
  title =	{{Hardness Results on Characteristics for Elastic-Degenerate Strings}},
  booktitle =	{37th Annual Symposium on Combinatorial Pattern Matching (CPM 2026)},
  pages =	{14:1--14:25},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-420-8},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{369},
  editor =	{Bille, Philip and Prezza, Nicola},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.CPM.2026.14},
  URN =		{urn:nbn:de:0030-drops-259409},
  doi =		{10.4230/LIPIcs.CPM.2026.14},
  annote =	{Keywords: Elastic-degenerate strings, NP-hardness, longest common factor, minimal unique substring, minimal absent word, anti-power, longest previous factor}
}
Document
Finding Diverse Solutions in Combinatorial Problems with a Distributive Lattice Structure

Authors: Mark de Berg, Andrés López Martínez, and Frits Spieksma

Published in: LIPIcs, Volume 359, 36th International Symposium on Algorithms and Computation (ISAAC 2025)


Abstract
We generalize the polynomial-time solvability of k-Diverse Minimum s-t Cuts (De Berg et al., ISAAC'23) to a wider class of combinatorial problems whose solution sets have a distributive lattice structure. We identify three structural conditions that, when met by a problem, ensure that a k-sized multiset of maximally-diverse solutions - measured by the sum of pairwise Hamming distances - can be found in polynomial time. We apply this framework to obtain polynomial-time algorithms for finding diverse minimum s-t cuts, diverse stable matchings, and diverse market-clearing price vectors. Moreover, we show that the framework extends to two other natural measures of diversity. Lastly, we present a simpler algorithmic framework for finding a largest set of pairwise disjoint solutions in problems that meet these structural conditions.

Cite as

Mark de Berg, Andrés López Martínez, and Frits Spieksma. Finding Diverse Solutions in Combinatorial Problems with a Distributive Lattice Structure. In 36th International Symposium on Algorithms and Computation (ISAAC 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 359, pp. 11:1-11:19, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)


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@InProceedings{deberg_et_al:LIPIcs.ISAAC.2025.11,
  author =	{de Berg, Mark and L\'{o}pez Mart{\'\i}nez, Andr\'{e}s and Spieksma, Frits},
  title =	{{Finding Diverse Solutions in Combinatorial Problems with a Distributive Lattice Structure}},
  booktitle =	{36th International Symposium on Algorithms and Computation (ISAAC 2025)},
  pages =	{11:1--11:19},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-408-6},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{359},
  editor =	{Chen, Ho-Lin and Hon, Wing-Kai and Tsai, Meng-Tsung},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ISAAC.2025.11},
  URN =		{urn:nbn:de:0030-drops-249197},
  doi =		{10.4230/LIPIcs.ISAAC.2025.11},
  annote =	{Keywords: Diversity, Lattice Theory, Submodular Function Minimization}
}
Document
Max-Distance Sparsification for Diversification and Clustering

Authors: Soh Kumabe

Published in: LIPIcs, Volume 351, 33rd Annual European Symposium on Algorithms (ESA 2025)


Abstract
Let 𝒟 be a set family that is the solution domain of some combinatorial problem. The max-min diversification problem on 𝒟 is the problem to select k sets from 𝒟 such that the Hamming distance between any two selected sets is at least d. FPT algorithms parameterized by k+𝓁, where 𝓁 = max_{D ∈ 𝒟}|D|, and k+d have been actively studied recently for several specific domains. This paper provides unified algorithmic frameworks to solve this problem. Specifically, for each parameterization k+𝓁 and k+d, we provide an FPT oracle algorithm for the max-min diversification problem using oracles related to 𝒟. We then demonstrate that our frameworks provide the first FPT algorithms on several new domains 𝒟, including the domain of t-linear matroid intersection, almost 2-SAT, minimum edge s,t-flows, vertex sets of s,t-mincut, vertex sets of edge bipartization, and Steiner trees. We also demonstrate that our frameworks generalize most of the existing domain-specific tractability results. Our main technical breakthrough is introducing the notion of max-distance sparsifier of 𝒟, a domain on which the max-min diversification problem is equivalent to the same problem on the original domain 𝒟. The core of our framework is to design FPT oracle algorithms that construct a constant-size max-distance sparsifier of 𝒟. Using max-distance sparsifiers, we provide FPT algorithms for the max-min and max-sum diversification problems on 𝒟, as well as k-center and k-sum-of-radii clustering problems on 𝒟, which are also natural problems in the context of diversification and have their own interests.

Cite as

Soh Kumabe. Max-Distance Sparsification for Diversification and Clustering. In 33rd Annual European Symposium on Algorithms (ESA 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 351, pp. 46:1-46:14, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)


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@InProceedings{kumabe:LIPIcs.ESA.2025.46,
  author =	{Kumabe, Soh},
  title =	{{Max-Distance Sparsification for Diversification and Clustering}},
  booktitle =	{33rd Annual European Symposium on Algorithms (ESA 2025)},
  pages =	{46:1--46:14},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-395-9},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{351},
  editor =	{Benoit, Anne and Kaplan, Haim and Wild, Sebastian and Herman, Grzegorz},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ESA.2025.46},
  URN =		{urn:nbn:de:0030-drops-245146},
  doi =		{10.4230/LIPIcs.ESA.2025.46},
  annote =	{Keywords: Fixed-Parameter Tractability, Diversification, Clustering}
}
Document
Research
Specific Patterns Against Reference Sequences

Authors: Marie-Pierre Béal and Maxime Crochemore

Published in: OASIcs, Volume 132, From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday (2025)


Abstract
We design alignment-free techniques for comparing a set of sequences or just a word, called a target, against another set of words, called a reference. This is done with the detection of factor patterns that distinguish the target from the reference. A target-specific factor of a target T against a reference R is then a factor w of a word in T that is not a factor of a word in R but whose proper factors of w are factors of a word in R. The strategy is based on the notion of minimal absent/forbidden words. We first address the computation of the set of target-specific factors of a target T against a reference R, where T and R are finite sets of sequences. The result is the construction of an automaton accepting the set of all considered target-specific factors. The construction algorithm runs in linear time according to the size of T ∪ R. The second result is the design of an algorithm to compute all the occurrences in a single sequence T of its target-specific factors against a reference R. The algorithm runs in real-time on the target sequence, independently of the number of occurrences of target-specific factors.

Cite as

Marie-Pierre Béal and Maxime Crochemore. Specific Patterns Against Reference Sequences. In From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 132, pp. 14:1-14:12, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)


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@InProceedings{beal_et_al:OASIcs.Grossi.14,
  author =	{B\'{e}al, Marie-Pierre and Crochemore, Maxime},
  title =	{{Specific Patterns Against Reference Sequences}},
  booktitle =	{From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday},
  pages =	{14:1--14:12},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-391-1},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{132},
  editor =	{Conte, Alessio and Marino, Andrea and Rosone, Giovanna and Vitter, Jeffrey Scott},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Grossi.14},
  URN =		{urn:nbn:de:0030-drops-238130},
  doi =		{10.4230/OASIcs.Grossi.14},
  annote =	{Keywords: Specific pattern, Minimal absent word, Minimal forbidden word, Directed Acyclic Word Graph (DAWG), Suffix automaton}
}
Document
Research
On String and Graph Sanitization

Authors: Giulia Bernardini, Huiping Chen, Grigorios Loukides, and Solon P. Pissis

Published in: OASIcs, Volume 132, From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday (2025)


Abstract
Data sanitization is a process that conceals sensitive patterns from a given dataset. A secondary goal is to not severely harm the utility of the underlying data along this process. We survey some recent advancements on two related data sanitization topics: string and graph sanitization. In particular, we highlight the important contributions of our friend Prof. Roberto Grossi along this journey.

Cite as

Giulia Bernardini, Huiping Chen, Grigorios Loukides, and Solon P. Pissis. On String and Graph Sanitization. In From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 132, pp. 9:1-9:10, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)


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@InProceedings{bernardini_et_al:OASIcs.Grossi.9,
  author =	{Bernardini, Giulia and Chen, Huiping and Loukides, Grigorios and Pissis, Solon P.},
  title =	{{On String and Graph Sanitization}},
  booktitle =	{From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday},
  pages =	{9:1--9:10},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-391-1},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{132},
  editor =	{Conte, Alessio and Marino, Andrea and Rosone, Giovanna and Vitter, Jeffrey Scott},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Grossi.9},
  URN =		{urn:nbn:de:0030-drops-238086},
  doi =		{10.4230/OASIcs.Grossi.9},
  annote =	{Keywords: data privacy, data sanitization, string algorithms, graph algorithms}
}
Document
Research
Designing Output Sensitive Algorithms for Subgraph Enumeration

Authors: Alessio Conte, Kazuhiro Kurita, Andrea Marino, Giulia Punzi, Takeaki Uno, and Kunihiro Wasa

Published in: OASIcs, Volume 132, From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday (2025)


Abstract
The enumeration of all subgraphs respecting some structural property is a fundamental task in theoretical computer science, with practical applications in many branches of data mining and network analysis. It is often of interest to only consider solutions (subgraphs) that are maximal under inclusion, and to achieve output-sensitive complexity, i.e., bounding the running time with respect to the number of subgraphs produced. In this paper, we provide a survey of techniques for designing output-sensitive algorithms for subgraph enumeration, including partition-based approaches such as flashlight search, solution-graph traversal methods such as reverse search, and cost amortization strategies such as push-out amortization. We also briefly discuss classes of efficiency, hardness of enumeration, and variants such as approximate enumeration. The paper is meant as an accessible handbook for learning the basics of the field and as a practical reference for selecting state-of-the-art subgraph enumeration strategies fitting to one’s needs.

Cite as

Alessio Conte, Kazuhiro Kurita, Andrea Marino, Giulia Punzi, Takeaki Uno, and Kunihiro Wasa. Designing Output Sensitive Algorithms for Subgraph Enumeration. In From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 132, pp. 19:1-19:40, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)


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@InProceedings{conte_et_al:OASIcs.Grossi.19,
  author =	{Conte, Alessio and Kurita, Kazuhiro and Marino, Andrea and Punzi, Giulia and Uno, Takeaki and Wasa, Kunihiro},
  title =	{{Designing Output Sensitive Algorithms for Subgraph Enumeration}},
  booktitle =	{From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday},
  pages =	{19:1--19:40},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-391-1},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{132},
  editor =	{Conte, Alessio and Marino, Andrea and Rosone, Giovanna and Vitter, Jeffrey Scott},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Grossi.19},
  URN =		{urn:nbn:de:0030-drops-238180},
  doi =		{10.4230/OASIcs.Grossi.19},
  annote =	{Keywords: Graph algorithms, Graph enumeration, Output sensitive enumeration}
}
Document
Research
Subsequence-Based Indices for Genome Sequence Analysis

Authors: Giovanni Buzzega, Alessio Conte, Veronica Guerrini, Giulia Punzi, Giovanna Rosone, and Lorenzo Tattini

Published in: OASIcs, Volume 132, From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday (2025)


Abstract
Compact indices are a fundamental tool in string analysis, even more so in bioinformatics, where genomic sequences can reach billions in length. This paper presents some recent results in which Roberto Grossi has been involved, showing how some of these indices do more than just efficiently represent data, but rather are able to bring out salient information within it, which can be exploited for their downstream analysis. Specifically, we first review a recently-introduced method [Guerrini et al., 2023] that employs the Burrows-Wheeler Transform to build reasonably accurate phylogenetic trees in an assembly-free scenario. We then describe a recent practical tool [Buzzega et al., 2025] for indexing Maximal Common Subsequences between strings, which can enable analysis of genomic sequence similarity. Experimentally, we show that the results produced by the one index are consistent with the expectations about the results of the other index.

Cite as

Giovanni Buzzega, Alessio Conte, Veronica Guerrini, Giulia Punzi, Giovanna Rosone, and Lorenzo Tattini. Subsequence-Based Indices for Genome Sequence Analysis. In From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 132, pp. 20:1-20:21, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)


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@InProceedings{buzzega_et_al:OASIcs.Grossi.20,
  author =	{Buzzega, Giovanni and Conte, Alessio and Guerrini, Veronica and Punzi, Giulia and Rosone, Giovanna and Tattini, Lorenzo},
  title =	{{Subsequence-Based Indices for Genome Sequence Analysis}},
  booktitle =	{From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday},
  pages =	{20:1--20:21},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-391-1},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{132},
  editor =	{Conte, Alessio and Marino, Andrea and Rosone, Giovanna and Vitter, Jeffrey Scott},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Grossi.20},
  URN =		{urn:nbn:de:0030-drops-238199},
  doi =		{10.4230/OASIcs.Grossi.20},
  annote =	{Keywords: String Indices, Burrows-Wheeler Transform, Maximal Common Subsequences, Sequence Analysis, Phylogeny}
}
Document
Shortest Undirected Paths in de Bruijn Graphs

Authors: Wiktor Zuba, Oded Lachish, and Solon P. Pissis

Published in: LIPIcs, Volume 331, 36th Annual Symposium on Combinatorial Pattern Matching (CPM 2025)


Abstract
Computing shortest directed paths in de Bruijn graphs is well studied and well understood. This is not the case for computing undirected paths, which is much more challenging algorithmically. In this paper, we present a general framework for computing shortest undirected paths in arbitrary de Bruijn graphs, that is, arbitrary subgraphs of the complete de Bruijn graph. We then present an application of our techniques for making any arbitrary order-k de Bruijn graph G(V,E) weakly connected by adding a set of edges of minimum total cost. This improves the running time of the recent (2-2/d)-approximation algorithm by Bernardini et al. [CPM 2024] from 𝒪(k|V|²) to 𝒪(k|V|log d) time, where d is the number of weakly connected components of graph G.

Cite as

Wiktor Zuba, Oded Lachish, and Solon P. Pissis. Shortest Undirected Paths in de Bruijn Graphs. In 36th Annual Symposium on Combinatorial Pattern Matching (CPM 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 331, pp. 12:1-12:13, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)


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@InProceedings{zuba_et_al:LIPIcs.CPM.2025.12,
  author =	{Zuba, Wiktor and Lachish, Oded and Pissis, Solon P.},
  title =	{{Shortest Undirected Paths in de Bruijn Graphs}},
  booktitle =	{36th Annual Symposium on Combinatorial Pattern Matching (CPM 2025)},
  pages =	{12:1--12:13},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-369-0},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{331},
  editor =	{Bonizzoni, Paola and M\"{a}kinen, Veli},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.CPM.2025.12},
  URN =		{urn:nbn:de:0030-drops-231060},
  doi =		{10.4230/LIPIcs.CPM.2025.12},
  annote =	{Keywords: string algorithm, graph algorithm, de Bruijn graph, Eulerian graph}
}
Document
McDag: Indexing Maximal Common Subsequences in Practice

Authors: Giovanni Buzzega, Alessio Conte, Roberto Grossi, and Giulia Punzi

Published in: LIPIcs, Volume 312, 24th International Workshop on Algorithms in Bioinformatics (WABI 2024)


Abstract
Analyzing and comparing sequences of symbols is among the most fundamental problems in computer science, possibly even more so in bioinformatics. Maximal Common Subsequences (MCSs), i.e., inclusion-maximal sequences of non-contiguous symbols common to two or more strings, have only recently received attention in this area, despite being a basic notion and a natural generalization of more common tools like Longest Common Substrings/Subsequences. In this paper we simplify and engineer recent advancements on MCSs into a practical tool called McDag, the first publicly available tool that can index MCSs of real genomic data. We demonstrate that our tool can index sequences exceeding 10,000 base pairs within minutes, utilizing only 4-7% more than the minimum required nodes, while also extracting relevant insights.

Cite as

Giovanni Buzzega, Alessio Conte, Roberto Grossi, and Giulia Punzi. McDag: Indexing Maximal Common Subsequences in Practice. In 24th International Workshop on Algorithms in Bioinformatics (WABI 2024). Leibniz International Proceedings in Informatics (LIPIcs), Volume 312, pp. 21:1-21:18, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2024)


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@InProceedings{buzzega_et_al:LIPIcs.WABI.2024.21,
  author =	{Buzzega, Giovanni and Conte, Alessio and Grossi, Roberto and Punzi, Giulia},
  title =	{{McDag: Indexing Maximal Common Subsequences in Practice}},
  booktitle =	{24th International Workshop on Algorithms in Bioinformatics (WABI 2024)},
  pages =	{21:1--21:18},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-340-9},
  ISSN =	{1868-8969},
  year =	{2024},
  volume =	{312},
  editor =	{Pissis, Solon P. and Sung, Wing-Kin},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2024.21},
  URN =		{urn:nbn:de:0030-drops-206650},
  doi =		{10.4230/LIPIcs.WABI.2024.21},
  annote =	{Keywords: Index data structure, DAG, Common subsequence, Inclusion-wise maximality, LCS}
}
Document
Finding Diverse Strings and Longest Common Subsequences in a Graph

Authors: Yuto Shida, Giulia Punzi, Yasuaki Kobayashi, Takeaki Uno, and Hiroki Arimura

Published in: LIPIcs, Volume 296, 35th Annual Symposium on Combinatorial Pattern Matching (CPM 2024)


Abstract
In this paper, we study for the first time the Diverse Longest Common Subsequences (LCSs) problem under Hamming distance. Given a set of a constant number of input strings, the problem asks to decide if there exists some subset X of K longest common subsequences whose diversity is no less than a specified threshold Δ, where we consider two types of diversities of a set X of strings of equal length: the Sum diversity and the Min diversity defined as the sum and the minimum of the pairwise Hamming distance between any two strings in X, respectively. We analyze the computational complexity of the respective problems with Sum- and Min-diversity measures, called the Max-Sum and Max-Min Diverse LCSs, respectively, considering both approximation algorithms and parameterized complexity. Our results are summarized as follows. When K is bounded, both problems are polynomial time solvable. In contrast, when K is unbounded, both problems become NP-hard, while Max-Sum Diverse LCSs problem admits a PTAS. Furthermore, we analyze the parameterized complexity of both problems with combinations of parameters K and r, where r is the length of the candidate strings to be selected. Importantly, all positive results above are proven in a more general setting, where an input is an edge-labeled directed acyclic graph (DAG) that succinctly represents a set of strings of the same length. Negative results are proven in the setting where an input is explicitly given as a set of strings. The latter results are equipped with an encoding such a set as the longest common subsequences of a specific input string set.

Cite as

Yuto Shida, Giulia Punzi, Yasuaki Kobayashi, Takeaki Uno, and Hiroki Arimura. Finding Diverse Strings and Longest Common Subsequences in a Graph. In 35th Annual Symposium on Combinatorial Pattern Matching (CPM 2024). Leibniz International Proceedings in Informatics (LIPIcs), Volume 296, pp. 27:1-27:19, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2024)


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@InProceedings{shida_et_al:LIPIcs.CPM.2024.27,
  author =	{Shida, Yuto and Punzi, Giulia and Kobayashi, Yasuaki and Uno, Takeaki and Arimura, Hiroki},
  title =	{{Finding Diverse Strings and Longest Common Subsequences in a Graph}},
  booktitle =	{35th Annual Symposium on Combinatorial Pattern Matching (CPM 2024)},
  pages =	{27:1--27:19},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-326-3},
  ISSN =	{1868-8969},
  year =	{2024},
  volume =	{296},
  editor =	{Inenaga, Shunsuke and Puglisi, Simon J.},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.CPM.2024.27},
  URN =		{urn:nbn:de:0030-drops-201370},
  doi =		{10.4230/LIPIcs.CPM.2024.27},
  annote =	{Keywords: Sequence analysis, longest common subsequence, Hamming distance, dispersion, approximation algorithms, parameterized complexity}
}
Document
A Compact DAG for Storing and Searching Maximal Common Subsequences

Authors: Alessio Conte, Roberto Grossi, Giulia Punzi, and Takeaki Uno

Published in: LIPIcs, Volume 283, 34th International Symposium on Algorithms and Computation (ISAAC 2023)


Abstract
Maximal Common Subsequences (MCSs) between two strings X and Y are subsequences of both X and Y that are maximal under inclusion. MCSs relax and generalize the well known and widely used concept of Longest Common Subsequences (LCSs), which can be seen as MCSs of maximum length. While the number both LCSs and MCSs can be exponential in the length of the strings, LCSs have been long exploited for string and text analysis, as simple compact representations of all LCSs between two strings, built via dynamic programming or automata, have been known since the '70s. MCSs appear to have a more challenging structure: even listing them efficiently was an open problem open until recently, thus narrowing the complexity difference between the two problems, but the gap remained significant. In this paper we close the complexity gap: we show how to build DAG of polynomial size - in polynomial time - which allows for efficient operations on the set of all MCSs such as enumeration in Constant Amortized Time per solution (CAT), counting, and random access to the i-th element (i.e., rank and select operations). Other than improving known algorithmic results, this work paves the way for new sequence analysis methods based on MCSs.

Cite as

Alessio Conte, Roberto Grossi, Giulia Punzi, and Takeaki Uno. A Compact DAG for Storing and Searching Maximal Common Subsequences. In 34th International Symposium on Algorithms and Computation (ISAAC 2023). Leibniz International Proceedings in Informatics (LIPIcs), Volume 283, pp. 21:1-21:15, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2023)


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@InProceedings{conte_et_al:LIPIcs.ISAAC.2023.21,
  author =	{Conte, Alessio and Grossi, Roberto and Punzi, Giulia and Uno, Takeaki},
  title =	{{A Compact DAG for Storing and Searching Maximal Common Subsequences}},
  booktitle =	{34th International Symposium on Algorithms and Computation (ISAAC 2023)},
  pages =	{21:1--21:15},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-289-1},
  ISSN =	{1868-8969},
  year =	{2023},
  volume =	{283},
  editor =	{Iwata, Satoru and Kakimura, Naonori},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ISAAC.2023.21},
  URN =		{urn:nbn:de:0030-drops-193231},
  doi =		{10.4230/LIPIcs.ISAAC.2023.21},
  annote =	{Keywords: Maximal common subsequence, DAG, Compact data structures, Enumeration, Constant amortized time, Random access}
}
Document
On Strings Having the Same Length- k Substrings

Authors: Giulia Bernardini, Alessio Conte, Esteban Gabory, Roberto Grossi, Grigorios Loukides, Solon P. Pissis, Giulia Punzi, and Michelle Sweering

Published in: LIPIcs, Volume 223, 33rd Annual Symposium on Combinatorial Pattern Matching (CPM 2022)


Abstract
Let Substr_k(X) denote the set of length-k substrings of a given string X for a given integer k > 0. We study the following basic string problem, called z-Shortest 𝒮_k-Equivalent Strings: Given a set 𝒮_k of n length-k strings and an integer z > 0, list z shortest distinct strings T₁,…,T_z such that Substr_k(T_i) = 𝒮_k, for all i ∈ [1,z]. The z-Shortest 𝒮_k-Equivalent Strings problem arises naturally as an encoding problem in many real-world applications; e.g., in data privacy, in data compression, and in bioinformatics. The 1-Shortest 𝒮_k-Equivalent Strings, referred to as Shortest 𝒮_k-Equivalent String, asks for a shortest string X such that Substr_k(X) = 𝒮_k. Our main contributions are summarized below: - Given a directed graph G(V,E), the Directed Chinese Postman (DCP) problem asks for a shortest closed walk that visits every edge of G at least once. DCP can be solved in 𝒪̃(|E||V|) time using an algorithm for min-cost flow. We show, via a non-trivial reduction, that if Shortest 𝒮_k-Equivalent String over a binary alphabet has a near-linear-time solution then so does DCP. - We show that the length of a shortest string output by Shortest 𝒮_k-Equivalent String is in 𝒪(k+n²). We generalize this bound by showing that the total length of z shortest strings is in 𝒪(zk+zn²+z²n). We derive these upper bounds by showing (asymptotically tight) bounds on the total length of z shortest Eulerian walks in general directed graphs. - We present an algorithm for solving z-Shortest 𝒮_k-Equivalent Strings in 𝒪(nk+n²log²n+zn²log n+|output|) time. If z = 1, the time becomes 𝒪(nk+n²log²n) by the fact that the size of the input is Θ(nk) and the size of the output is 𝒪(k+n²).

Cite as

Giulia Bernardini, Alessio Conte, Esteban Gabory, Roberto Grossi, Grigorios Loukides, Solon P. Pissis, Giulia Punzi, and Michelle Sweering. On Strings Having the Same Length- k Substrings. In 33rd Annual Symposium on Combinatorial Pattern Matching (CPM 2022). Leibniz International Proceedings in Informatics (LIPIcs), Volume 223, pp. 16:1-16:17, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2022)


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@InProceedings{bernardini_et_al:LIPIcs.CPM.2022.16,
  author =	{Bernardini, Giulia and Conte, Alessio and Gabory, Esteban and Grossi, Roberto and Loukides, Grigorios and Pissis, Solon P. and Punzi, Giulia and Sweering, Michelle},
  title =	{{On Strings Having the Same Length- k Substrings}},
  booktitle =	{33rd Annual Symposium on Combinatorial Pattern Matching (CPM 2022)},
  pages =	{16:1--16:17},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-234-1},
  ISSN =	{1868-8969},
  year =	{2022},
  volume =	{223},
  editor =	{Bannai, Hideo and Holub, Jan},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.CPM.2022.16},
  URN =		{urn:nbn:de:0030-drops-161439},
  doi =		{10.4230/LIPIcs.CPM.2022.16},
  annote =	{Keywords: string algorithms, combinatorics on words, de Bruijn graph, Chinese Postman}
}
Document
Enumeration of s-d Separators in DAGs with Application to Reliability Analysis in Temporal Graphs

Authors: Alessio Conte, Pierluigi Crescenzi, Andrea Marino, and Giulia Punzi

Published in: LIPIcs, Volume 170, 45th International Symposium on Mathematical Foundations of Computer Science (MFCS 2020)


Abstract
Temporal graphs are graphs in which arcs have temporal labels, specifying at which time they can be traversed. Motivated by recent results concerning the reliability analysis of a temporal graph through the enumeration of minimal cutsets in the corresponding line graph, in this paper we attack the problem of enumerating minimal s-d separators in s-d directed acyclic graphs (in short, s-d DAGs), also known as 2-terminal DAGs or s-t digraphs. Our main result is an algorithm for enumerating all the minimal s-d separators in a DAG with O(nm) delay, where n and m are respectively the number of nodes and arcs, and the delay is the time between the output of two consecutive solutions. To this aim, we give a characterization of the minimal s-d separators in a DAG through vertex cuts of an expanded version of the DAG itself. As a consequence of our main result, we provide an algorithm for enumerating all the minimal s-d cutsets in a temporal graph with delay O(m³), where m is the number of temporal arcs.

Cite as

Alessio Conte, Pierluigi Crescenzi, Andrea Marino, and Giulia Punzi. Enumeration of s-d Separators in DAGs with Application to Reliability Analysis in Temporal Graphs. In 45th International Symposium on Mathematical Foundations of Computer Science (MFCS 2020). Leibniz International Proceedings in Informatics (LIPIcs), Volume 170, pp. 25:1-25:14, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2020)


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@InProceedings{conte_et_al:LIPIcs.MFCS.2020.25,
  author =	{Conte, Alessio and Crescenzi, Pierluigi and Marino, Andrea and Punzi, Giulia},
  title =	{{Enumeration of s-d Separators in DAGs with Application to Reliability Analysis in Temporal Graphs}},
  booktitle =	{45th International Symposium on Mathematical Foundations of Computer Science (MFCS 2020)},
  pages =	{25:1--25:14},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-159-7},
  ISSN =	{1868-8969},
  year =	{2020},
  volume =	{170},
  editor =	{Esparza, Javier and Kr\'{a}l', Daniel},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.MFCS.2020.25},
  URN =		{urn:nbn:de:0030-drops-126932},
  doi =		{10.4230/LIPIcs.MFCS.2020.25},
  annote =	{Keywords: minimal cutset, temporal graph, minimal separator, directed acyclic graph}
}
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