14 Search Results for "Rivals, Eric"

Document
DOI: 10.4230/LIPIcs.ESA.2025.8
Fast Computation of k-Runs, Parameterized Squares, and Other Generalised Squares

Authors: Yuto Nakashima, Jakub Radoszewski, and Tomasz Waleń

Published in: LIPIcs, Volume 351, 33rd Annual European Symposium on Algorithms (ESA 2025)

Abstract
A k-mismatch square is a string of the form XY where X and Y are two equal-length strings that have at most k mismatches. Kolpakov and Kucherov [Theor. Comput. Sci., 2003] defined two notions of k-mismatch repeats, called k-repetitions and k-runs, each representing a sequence of consecutive k-mismatch squares of equal length. They proposed algorithms for computing k-repetitions and k-runs working in 𝒪(nklog k+output) time for a string of length n over an integer alphabet, where output is the number of the reported repeats. We show that output = 𝒪(nk log k), both in case of k-repetitions and k-runs, which implies that the complexity of their algorithms is actually 𝒪(nk log k). We apply this result to computing parameterized squares. A parameterized square is a string of the form XY such that X and Y parameterized-match, i.e., there exists a bijection f on the alphabet such that f(X) = Y. Two parameterized squares XY and X'Y' are equivalent if they parameterized match. Recently Hamai et al. [SPIRE 2024] showed that a string of length n over an alphabet of size σ contains less than nσ non-equivalent parameterized squares, improving an earlier bound by Kociumaka et al. [Theor. Comput. Sci., 2016]. We apply our bound for k-mismatch repeats to propose an algorithm that reports all non-equivalent parameterized squares in 𝒪(nσ log σ) time. We also show that the number of non-equivalent parameterized squares can be computed in 𝒪(n log n) time. This last algorithm applies to squares under any substring compatible equivalence relation and also to counting squares that are distinct as strings. In particular, this improves upon the 𝒪(nσ)-time algorithm of Gawrychowski et al. [CPM 2023] for counting order-preserving squares that are distinct as strings if σ = ω(log n).
Cite as

Yuto Nakashima, Jakub Radoszewski, and Tomasz Waleń. Fast Computation of k-Runs, Parameterized Squares, and Other Generalised Squares. In 33rd Annual European Symposium on Algorithms (ESA 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 351, pp. 8:1-8:18, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{nakashima_et_al:LIPIcs.ESA.2025.8,
  author =	{Nakashima, Yuto and Radoszewski, Jakub and Wale\'{n}, Tomasz},
  title =	{{Fast Computation of k-Runs, Parameterized Squares, and Other Generalised Squares}},
  booktitle =	{33rd Annual European Symposium on Algorithms (ESA 2025)},
  pages =	{8:1--8:18},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-395-9},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{351},
  editor =	{Benoit, Anne and Kaplan, Haim and Wild, Sebastian and Herman, Grzegorz},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ESA.2025.8},
  URN =		{urn:nbn:de:0030-drops-244768},
  doi =		{10.4230/LIPIcs.ESA.2025.8},
  annote =	{Keywords: string algorithm, k-mismatch square, parameterized square, order-preserving square, maximum gapped repeat}
}
Document
DOI: 10.4230/LIPIcs.ESA.2025.111
Hardness of Median and Center in the Ulam Metric

Authors: Nick Fischer, Elazar Goldenberg, Mursalin Habib, and Karthik C. S.

Published in: LIPIcs, Volume 351, 33rd Annual European Symposium on Algorithms (ESA 2025)

Abstract
The classical rank aggregation problem seeks to combine a set X of n permutations into a single representative "consensus" permutation. In this paper, we investigate two fundamental rank aggregation tasks under the well-studied Ulam metric: computing a median permutation (which minimizes the sum of Ulam distances to X) and computing a center permutation (which minimizes the maximum Ulam distance to X) in two settings. - Continuous Setting: In the continuous setting, the median/center is allowed to be any permutation. It is known that computing a center in the Ulam metric is NP-hard and we add to this by showing that computing a median is NP-hard as well via a simple reduction from the Max-Cut problem. While this result may not be unexpected, it had remained elusive until now and confirms a speculation by Chakraborty, Das, and Krauthgamer [SODA '21]. - Discrete Setting: In the discrete setting, the median/center must be a permutation from the input set. We fully resolve the fine-grained complexity of the discrete median and discrete center problems under the Ulam metric, proving that the naive Õ(n² L)-time algorithm (where L is the length of the permutation) is conditionally optimal. This resolves an open problem raised by Abboud, Bateni, Cohen-Addad, Karthik C. S., and Seddighin [APPROX '23]. Our reductions are inspired by the known fine-grained lower bounds for similarity measures, but we face and overcome several new highly technical challenges.
Cite as

Nick Fischer, Elazar Goldenberg, Mursalin Habib, and Karthik C. S.. Hardness of Median and Center in the Ulam Metric. In 33rd Annual European Symposium on Algorithms (ESA 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 351, pp. 111:1-111:17, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{fischer_et_al:LIPIcs.ESA.2025.111,
  author =	{Fischer, Nick and Goldenberg, Elazar and Habib, Mursalin and Karthik C. S.},
  title =	{{Hardness of Median and Center in the Ulam Metric}},
  booktitle =	{33rd Annual European Symposium on Algorithms (ESA 2025)},
  pages =	{111:1--111:17},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-395-9},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{351},
  editor =	{Benoit, Anne and Kaplan, Haim and Wild, Sebastian and Herman, Grzegorz},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ESA.2025.111},
  URN =		{urn:nbn:de:0030-drops-245809},
  doi =		{10.4230/LIPIcs.ESA.2025.111},
  annote =	{Keywords: Ulam distance, median, center, rank aggregation, fine-grained complexity}
}
Document
DOI: 10.4230/LIPIcs.WABI.2025.6
Fast Pseudoalignment Queries on Compressed Colored de Bruijn Graphs

Authors: Alessio Campanelli, Giulio Ermanno Pibiri, and Rob Patro

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)

Abstract
Motivation. Indexes for the colored de Bruijn graph (c-dBG) play a crucial role in computational biology by facilitating complex tasks such as read mapping and assembly. These indexes map k-mers (substrings of length k) appearing in a large collection of reference strings to the set of identifiers of the strings where they appear. These sets, colloquially referred to as color sets, tend to occupy large quantities of memory, especially for large pangenomes. Our previous work thus focused on leveraging the repetitiveness of the color sets to improve the space effectiveness of the resulting index. As a matter of fact, repetition-aware indexes can be up to one order of magnitude smaller on large pangenomes compared to indexes that do not exploit such repetitiveness. Such improved space effectiveness, on the other hand, imposes an overhead at query time when performing tasks such as pseudoalignment that require the collection and processing of multiple related color sets. Methods. In this paper, we show how to avoid this overhead. We devise novel query algorithms tailored for the specific repetition-aware representations adopted by the Fulgor index, a state-of-the-art c-dBG index, to significantly improve its pseudoalignment efficiency and without consuming additional space. Results. Our results indicate that with increasing redundancy in the pangenomes, the compression factor provided by the Fulgor index increases, while the relative query time actually reduces. For example, while the space of the Fulgor index improves by 2.5× with repetition-aware compression and its query time improves by 1.6× on a collection of 5,000 Salmonella Enterica genomes, these factors become (6.1×,2.8×) and (11.2×,3.2×) for 50,000 and 150,000 genomes respectively. For an even larger collection of 300,000 genomes, we obtained an index that is 22.3× smaller and 2.2× faster.
Cite as

Alessio Campanelli, Giulio Ermanno Pibiri, and Rob Patro. Fast Pseudoalignment Queries on Compressed Colored de Bruijn Graphs. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 6:1-6:21, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{campanelli_et_al:LIPIcs.WABI.2025.6,
  author =	{Campanelli, Alessio and Pibiri, Giulio Ermanno and Patro, Rob},
  title =	{{Fast Pseudoalignment Queries on Compressed Colored de Bruijn Graphs}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{6:1--6:21},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.6},
  URN =		{urn:nbn:de:0030-drops-239327},
  doi =		{10.4230/LIPIcs.WABI.2025.6},
  annote =	{Keywords: Colored de Bruijn graphs, Pseudoalignment, Repetition-aware compression}
}
Document
DOI: 10.4230/LIPIcs.WABI.2025.22
Design of Worst-Case-Optimal Spaced Seeds

Authors: Jens Zentgraf and Sven Rahmann

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)

Abstract
Read mapping (and alignment) is a fundamental problem in biological sequence analysis. For speed and computational efficiency, many popular read mappers tolerate only a few differences between the read and the corresponding part of the reference genome, which leads to reference bias: Reads with too many differences are not guaranteed to be mapped correctly or at all, because to even consider a genomic position, a sufficiently long exact match (seed) must exist. While pangenomes and their graph-based representations provide one way to avoid reference bias by enlarging the reference, we explore an orthogonal approach and consider stronger substitution-tolerant primitives, namely spaced seeds or gapped k-mers. Given two integers k ≤ w, one considers k selected positions, described by a mask, from each length-w window in a sequence. In the existing literature, masks with certain probabilistic guarantees have been designed for small values of k. Here, for the first time, we take a combinatorial approach from a worst-case perspective. For any mask, using integer linear programs, we find least favorable distributions of sequence changes in two different senses: (1) minimizing the number of unchanged windows; (2) minimizing the number of positions covered by unchanged windows. Then, among all masks or all symmetric masks of a given shape (k,w), we find the set of best masks that maximize these minima. As a result, we obtain robust masks, even for large numbers of changes. We illustrate the properties of these masks by constructing a challenging set of reads that contain many approximately equidistributed substitutions (but no indels) that many existing tools cannot map, even though they are in principle easily mappable (apart from the large number of changes) because they originate from selected non-repetitive regions of the human reference genome. We observe that the majority of these reads can be mapped with a simple alignment-free approach using chosen spaced masks, where seeding approaches based on contiguous k-mers fail.
Cite as

Jens Zentgraf and Sven Rahmann. Design of Worst-Case-Optimal Spaced Seeds. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 22:1-22:17, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{zentgraf_et_al:LIPIcs.WABI.2025.22,
  author =	{Zentgraf, Jens and Rahmann, Sven},
  title =	{{Design of Worst-Case-Optimal Spaced Seeds}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{22:1--22:17},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.22},
  URN =		{urn:nbn:de:0030-drops-239488},
  doi =		{10.4230/LIPIcs.WABI.2025.22},
  annote =	{Keywords: Spaced seed, Gapped k-mer, Integer linear program (ILP), Worst-case design, Reference bias}
}
Document
DOI: 10.4230/OASIcs.Manzini.3
BWT for String Collections

Authors: Davide Cenzato, Zsuzsanna Lipták, Nadia Pisanti, Giovanna Rosone, and Marinella Sciortino

Published in: OASIcs, Volume 131, The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday (2025)

Abstract
We survey the different methods used for extending the BWT to collections of strings, following largely [Cenzato and Lipták, CPM 2022, Bioinformatics 2024]. We analyze the specific aspects and combinatorial properties of the resulting BWT variants and give a categorization of publicly available tools for computing the BWT of string collections. We show how the specific method used impacts on the resulting transform, including the number of runs, and on the dynamicity of the transform with respect to adding or removing strings from the collection. We then focus on the number of runs of these BWT variants and present the optimal BWT introduced in [Cenzato et al., DCC 2023], which implements an algorithm originally proposed by [Bentley et al., ESA 2020] to minimize the number of BWT-runs. We also discuss several recent heuristics and study their impact on the compression of biological sequences. We conclude with an overview of the applications and the impact of the BWT of string collections in bioinformatics.
Cite as

Davide Cenzato, Zsuzsanna Lipták, Nadia Pisanti, Giovanna Rosone, and Marinella Sciortino. BWT for String Collections. In The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 131, pp. 3:1-3:29, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{cenzato_et_al:OASIcs.Manzini.3,
  author =	{Cenzato, Davide and Lipt\'{a}k, Zsuzsanna and Pisanti, Nadia and Rosone, Giovanna and Sciortino, Marinella},
  title =	{{BWT for String Collections}},
  booktitle =	{The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday},
  pages =	{3:1--3:29},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-390-4},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{131},
  editor =	{Ferragina, Paolo and Gagie, Travis and Navarro, Gonzalo},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Manzini.3},
  URN =		{urn:nbn:de:0030-drops-239113},
  doi =		{10.4230/OASIcs.Manzini.3},
  annote =	{Keywords: Burrows-Wheeler transform, Extended Burrows-Wheeler transform, compressed text indexes, text compression, string collections, bioinformatics}
}
Document
DOI: 10.4230/OASIcs.Manzini.11
Circular Dictionary Matching Using Extended BWT

Authors: Wing-Kai Hon, Rahul Shah, and Sharma V. Thankachan

Published in: OASIcs, Volume 131, The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday (2025)

Abstract
The dictionary matching problem involves preprocessing a set of strings (patterns) into a data structure that efficiently identifies all occurrences of these patterns within a query string (text). In this work, we investigate a variation of this problem, termed circular dictionary matching, where the patterns are circular, meaning their cyclic shifts are also considered valid patterns. Such patterns naturally occur in areas such as bioinformatics and computational geometry. Based on the extended Burrows-Wheeler Transformation (eBWT), we design a space-efficient solution for this problem. Specifically, we show that a dictionary of d circular patterns of total length n can be indexed in nlog σ + O(n+dlog n+σ log n) bits of space and support circular dictionary matching on a query text T in O((|T|+occ)log n) time, where σ represents the size of the underlying alphabet and occ represents the output size.
Cite as

Wing-Kai Hon, Rahul Shah, and Sharma V. Thankachan. Circular Dictionary Matching Using Extended BWT. In The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 131, pp. 11:1-11:14, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{hon_et_al:OASIcs.Manzini.11,
  author =	{Hon, Wing-Kai and Shah, Rahul and Thankachan, Sharma V.},
  title =	{{Circular Dictionary Matching Using Extended BWT}},
  booktitle =	{The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday},
  pages =	{11:1--11:14},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-390-4},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{131},
  editor =	{Ferragina, Paolo and Gagie, Travis and Navarro, Gonzalo},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Manzini.11},
  URN =		{urn:nbn:de:0030-drops-239195},
  doi =		{10.4230/OASIcs.Manzini.11},
  annote =	{Keywords: String algorithms, Burrows-Wheeler transformation, suffix trees, succinct data structures}
}
Document
DOI: 10.4230/OASIcs.Manzini.13
Graph Indexing Beyond Wheeler Graphs

Authors: Jarno N. Alanko, Elena Biagi, Massimo Equi, Veli Mäkinen, Simon J. Puglisi, Nicola Rizzo, Kunihiko Sadakane, and Jouni Sirén

Published in: OASIcs, Volume 131, The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday (2025)

Abstract
After the discovery of the FM index, which linked the Burrows-Wheeler transform (BWT) to pattern matching on strings, several contemporaneous strands of research began on indexing more complex structures with the BWT, such as tries, finite languages, de Bruijn graphs, and aligned sequences. These directions can now be viewed as culminating in the theory of Wheeler Graphs, but sometimes they go beyond. This chapter reviews the significant body of "proto Wheeler Graph" indexes, many of which exploit characteristics of their specific case to outperform Wheeler graphs, especially in practice.
Cite as

Jarno N. Alanko, Elena Biagi, Massimo Equi, Veli Mäkinen, Simon J. Puglisi, Nicola Rizzo, Kunihiko Sadakane, and Jouni Sirén. Graph Indexing Beyond Wheeler Graphs. In The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 131, pp. 13:1-13:29, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{alanko_et_al:OASIcs.Manzini.13,
  author =	{Alanko, Jarno N. and Biagi, Elena and Equi, Massimo and M\"{a}kinen, Veli and Puglisi, Simon J. and Rizzo, Nicola and Sadakane, Kunihiko and Sir\'{e}n, Jouni},
  title =	{{Graph Indexing Beyond Wheeler Graphs}},
  booktitle =	{The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday},
  pages =	{13:1--13:29},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-390-4},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{131},
  editor =	{Ferragina, Paolo and Gagie, Travis and Navarro, Gonzalo},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Manzini.13},
  URN =		{urn:nbn:de:0030-drops-239215},
  doi =		{10.4230/OASIcs.Manzini.13},
  annote =	{Keywords: indexing, compression, compressed data structures, string algorithms, pattern matching}
}
Document
DOI: 10.4230/LIPIcs.ITCS.2025.28
Coresets for 1-Center in 𝓁₁ Metrics

Authors: Amir Carmel, Chengzhi Guo, Shaofeng H.-C. Jiang, and Robert Krauthgamer

Published in: LIPIcs, Volume 325, 16th Innovations in Theoretical Computer Science Conference (ITCS 2025)

Abstract
We explore the applicability of coresets - a small subset of the input dataset that approximates a predefined set of queries - to the 1-center problem in 𝓁₁ spaces. This approach could potentially extend to solving the 1-center problem in related metric spaces, and has implications for streaming and dynamic algorithms. We show that in 𝓁₁, unlike in Euclidean space, even weak coresets exhibit exponential dependency on the underlying dimension. Moreover, while inputs with a unique optimal center admit better bounds, they are not dimension independent. We then relax the guarantee of the coreset further, to merely approximate the value (optimal cost of 1-center), and obtain a dimension-independent coreset for every desired accuracy ε > 0. Finally, we discuss the broader implications of our findings to related metric spaces, and show explicit implications to Jaccard and Kendall’s tau distances.
Cite as

Amir Carmel, Chengzhi Guo, Shaofeng H.-C. Jiang, and Robert Krauthgamer. Coresets for 1-Center in 𝓁₁ Metrics. In 16th Innovations in Theoretical Computer Science Conference (ITCS 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 325, pp. 28:1-28:20, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{carmel_et_al:LIPIcs.ITCS.2025.28,
  author =	{Carmel, Amir and Guo, Chengzhi and Jiang, Shaofeng H.-C. and Krauthgamer, Robert},
  title =	{{Coresets for 1-Center in 𝓁₁ Metrics}},
  booktitle =	{16th Innovations in Theoretical Computer Science Conference (ITCS 2025)},
  pages =	{28:1--28:20},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-361-4},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{325},
  editor =	{Meka, Raghu},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ITCS.2025.28},
  URN =		{urn:nbn:de:0030-drops-226566},
  doi =		{10.4230/LIPIcs.ITCS.2025.28},
  annote =	{Keywords: clustering, k-center, minimum enclosing balls, coresets, 𝓁₁ norm, Kendall’s tau, Jaccard metric}
}
Document
Track A: Algorithms, Complexity and Games
DOI: 10.4230/LIPIcs.ICALP.2023.100
Convergence of the Number of Period Sets in Strings

Authors: Eric Rivals, Michelle Sweering, and Pengfei Wang

Published in: LIPIcs, Volume 261, 50th International Colloquium on Automata, Languages, and Programming (ICALP 2023)

Abstract
Consider words of length n. The set of all periods of a word of length n is a subset of {0,1,2,…,n-1}. However, any subset of {0,1,2,…,n-1} is not necessarily a valid set of periods. In a seminal paper in 1981, Guibas and Odlyzko proposed to encode the set of periods of a word into an n long binary string, called an autocorrelation, where a one at position i denotes the period i. They considered the question of recognizing a valid period set, and also studied the number of valid period sets for strings of length n, denoted κ_n. They conjectured that ln(κ_n) asymptotically converges to a constant times ln²(n). Although improved lower bounds for ln(κ_n)/ln²(n) were proposed in 2001, the question of a tight upper bound has remained open since Guibas and Odlyzko’s paper. Here, we exhibit an upper bound for this fraction, which implies its convergence and closes this longstanding conjecture. Moreover, we extend our result to find similar bounds for the number of correlations: a generalization of autocorrelations which encodes the overlaps between two strings.
Cite as

Eric Rivals, Michelle Sweering, and Pengfei Wang. Convergence of the Number of Period Sets in Strings. In 50th International Colloquium on Automata, Languages, and Programming (ICALP 2023). Leibniz International Proceedings in Informatics (LIPIcs), Volume 261, pp. 100:1-100:14, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2023)

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@InProceedings{rivals_et_al:LIPIcs.ICALP.2023.100,
  author =	{Rivals, Eric and Sweering, Michelle and Wang, Pengfei},
  title =	{{Convergence of the Number of Period Sets in Strings}},
  booktitle =	{50th International Colloquium on Automata, Languages, and Programming (ICALP 2023)},
  pages =	{100:1--100:14},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-278-5},
  ISSN =	{1868-8969},
  year =	{2023},
  volume =	{261},
  editor =	{Etessami, Kousha and Feige, Uriel and Puppis, Gabriele},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ICALP.2023.100},
  URN =		{urn:nbn:de:0030-drops-181527},
  doi =		{10.4230/LIPIcs.ICALP.2023.100},
  annote =	{Keywords: Autocorrelation, period, border, combinatorics, correlation, periodicity, upper bound, asymptotic convergence}
}
Document
Invited Talk
DOI: 10.4230/LIPIcs.WABI.2022.1
Efficient Solutions to Biological Problems Using de Bruijn Graphs (Invited Talk)

Authors: Leena Salmela

Published in: LIPIcs, Volume 242, 22nd International Workshop on Algorithms in Bioinformatics (WABI 2022)

Abstract
The de Bruijn graph has become a standard method in the analysis of sequencing reads in computational biology due to its ability to represent the information contained in large read sets in small space. A de Bruijn graph represents a set of sequencing reads by its k-mers, i.e. the set of substrings of length k that occur in the reads. In the classical definition, the k-mers are the edges of the graph and the nodes are the k-1 bases long prefixes and suffixes of the k-mers. Usually only k-mers occurring several times in the read set are kept to filter out noise in the data. De Bruijn graphs have been used to solve many problems in computational biology including genome assembly [Ramana M. Idury and Michael S. Waterman, 1995; Pavel A. Pevzner et al., 2001; Anton Bankevich et al., 2012; Yu Peng et al., 2010], sequencing error correction [Leena Salmela and Eric Rivals, 2014; Giles Miclotte et al., 2016; Leena Salmela et al., 2017; Limasset et al., 2019], reference free variant calling [Raluca Uricaru et al., 2015], indexing read sets [Camille Marchet et al., 2021], and so on. Next I will discuss two of these problems in more depth. The de Bruijn graph first emerged in computation biology in the context of genome assembly [Ramana M. Idury and Michael S. Waterman, 1995; Pavel A. Pevzner et al., 2001] where the task is to reconstruct a genome based on sequencing reads. As the de Bruijn graph can represent large read sets compactly, it became the standard approach to assemble short reads [Anton Bankevich et al., 2012; Yu Peng et al., 2010]. In the theoretical framework of de Bruijn graph based genome assembly, a genome is thought to be the Eulerian path in the de Bruijn graph built on the sequencing reads. In practise, the Eulerian path is not unique and thus not useful in the biological context. Therefore, practical implementations report subpaths that are guaranteed to be part of any Eulerian path and thus part of the actual genome. Such models include unitigs, which are nonbranching paths of the de Bruijn graph, and more involved definitions such as omnitigs [Alexandru I. Tomescu and Paul Medvedev, 2017]. In genome assembly the choice of k is a crucial matter. A small k can result in a tangled graph, whereas a too large k will fragment the graph. Furthermore, a different value of k may be optimal for different parts of the genome. Variable order de Bruijn graphs [Christina Boucher et al., 2015; Djamal Belazzougui et al., 2016], which represent de Bruijn graphs of all orders k in a single data structure, have been proposed as a solution but no rigorous definition corresponding to unitigs has been presented. We give the first definition of assembled sequences, i.e. contigs, on such graphs and an algorithm for enumerating them. Another problem that can be solved with de Bruijn graphs is the correction of sequencing errors [Leena Salmela and Eric Rivals, 2014; Giles Miclotte et al., 2016; Leena Salmela et al., 2017; Limasset et al., 2019]. Because each position of a genome is sequenced several times, it is possible to correct sequencing errors in reads if we can identify data originating from the same genomic region. A de Bruijn graph can be used to represent compactly the reliable information and the individual reads can be corrected by aligning them to the graph.
Cite as

Leena Salmela. Efficient Solutions to Biological Problems Using de Bruijn Graphs (Invited Talk). In 22nd International Workshop on Algorithms in Bioinformatics (WABI 2022). Leibniz International Proceedings in Informatics (LIPIcs), Volume 242, pp. 1:1-1:2, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2022)

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@InProceedings{salmela:LIPIcs.WABI.2022.1,
  author =	{Salmela, Leena},
  title =	{{Efficient Solutions to Biological Problems Using de Bruijn Graphs}},
  booktitle =	{22nd International Workshop on Algorithms in Bioinformatics (WABI 2022)},
  pages =	{1:1--1:2},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-243-3},
  ISSN =	{1868-8969},
  year =	{2022},
  volume =	{242},
  editor =	{Boucher, Christina and Rahmann, Sven},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2022.1},
  URN =		{urn:nbn:de:0030-drops-170357},
  doi =		{10.4230/LIPIcs.WABI.2022.1},
  annote =	{Keywords: de Bruijn graph, variable order de Bruijn graph, genome assembly, sequencing error correction, k-mers}
}
Document
DOI: 10.4230/LIPIcs.CPM.2021.22
A Linear Time Algorithm for Constructing Hierarchical Overlap Graphs

Authors: Sangsoo Park, Sung Gwan Park, Bastien Cazaux, Kunsoo Park, and Eric Rivals

Published in: LIPIcs, Volume 191, 32nd Annual Symposium on Combinatorial Pattern Matching (CPM 2021)

Abstract
The hierarchical overlap graph (HOG) is a graph that encodes overlaps from a given set P of n strings, as the overlap graph does. A best known algorithm constructs HOG in O(||P|| log n) time and O(||P||) space, where ||P|| is the sum of lengths of the strings in P. In this paper we present a new algorithm to construct HOG in O(||P||) time and space. Hence, the construction time and space of HOG are better than those of the overlap graph, which are O(||P|| + n²).
Cite as

Sangsoo Park, Sung Gwan Park, Bastien Cazaux, Kunsoo Park, and Eric Rivals. A Linear Time Algorithm for Constructing Hierarchical Overlap Graphs. In 32nd Annual Symposium on Combinatorial Pattern Matching (CPM 2021). Leibniz International Proceedings in Informatics (LIPIcs), Volume 191, pp. 22:1-22:9, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2021)

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@InProceedings{park_et_al:LIPIcs.CPM.2021.22,
  author =	{Park, Sangsoo and Park, Sung Gwan and Cazaux, Bastien and Park, Kunsoo and Rivals, Eric},
  title =	{{A Linear Time Algorithm for Constructing Hierarchical Overlap Graphs}},
  booktitle =	{32nd Annual Symposium on Combinatorial Pattern Matching (CPM 2021)},
  pages =	{22:1--22:9},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-186-3},
  ISSN =	{1868-8969},
  year =	{2021},
  volume =	{191},
  editor =	{Gawrychowski, Pawe{\l} and Starikovskaya, Tatiana},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.CPM.2021.22},
  URN =		{urn:nbn:de:0030-drops-139736},
  doi =		{10.4230/LIPIcs.CPM.2021.22},
  annote =	{Keywords: overlap graph, hierarchical overlap graph, shortest superstring problem, border array}
}
Document
DOI: 10.4230/LIPIcs.CPM.2019.24
Linking BWT and XBW via Aho-Corasick Automaton: Applications to Run-Length Encoding

Authors: Bastien Cazaux and Eric Rivals

Published in: LIPIcs, Volume 128, 30th Annual Symposium on Combinatorial Pattern Matching (CPM 2019)

Abstract
The boom of genomic sequencing makes compression of sets of sequences inescapable. This underlies the need for multi-string indexing data structures that helps compressing the data. The most prominent example of such data structures is the Burrows-Wheeler Transform (BWT), a reversible permutation of a text that improves its compressibility. A similar data structure, the eXtended Burrows-Wheeler Transform (XBW), is able to index a tree labelled with alphabet symbols. A link between a multi-string BWT and the Aho-Corasick automaton has already been found and led to a way to build a XBW from a multi-string BWT. We exhibit a stronger link between a multi-string BWT and a XBW by using the order of the concatenation in the multi-string. This bijective link has several applications: first, it allows one to build one data structure from the other; second, it enables one to compute an ordering of the input strings that optimises a Run-Length measure (i.e., the compressibility) of the BWT or of the XBW.
Cite as

Bastien Cazaux and Eric Rivals. Linking BWT and XBW via Aho-Corasick Automaton: Applications to Run-Length Encoding. In 30th Annual Symposium on Combinatorial Pattern Matching (CPM 2019). Leibniz International Proceedings in Informatics (LIPIcs), Volume 128, pp. 24:1-24:20, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2019)

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@InProceedings{cazaux_et_al:LIPIcs.CPM.2019.24,
  author =	{Cazaux, Bastien and Rivals, Eric},
  title =	{{Linking BWT and XBW via Aho-Corasick Automaton: Applications to Run-Length Encoding}},
  booktitle =	{30th Annual Symposium on Combinatorial Pattern Matching (CPM 2019)},
  pages =	{24:1--24:20},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-103-0},
  ISSN =	{1868-8969},
  year =	{2019},
  volume =	{128},
  editor =	{Pisanti, Nadia and P. Pissis, Solon},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.CPM.2019.24},
  URN =		{urn:nbn:de:0030-drops-104955},
  doi =		{10.4230/LIPIcs.CPM.2019.24},
  annote =	{Keywords: Data Structure, Algorithm, Aho-Corasick Tree, compression, RLE}
}
Document
DOI: 10.4230/LIPIcs.SEA.2018.18
Practical lower and upper bounds for the Shortest Linear Superstring

Authors: Bastien Cazaux, Samuel Juhel, and Eric Rivals

Published in: LIPIcs, Volume 103, 17th International Symposium on Experimental Algorithms (SEA 2018)

Abstract
Given a set P of words, the Shortest Linear Superstring (SLS) problem is an optimisation problem that asks for a superstring of P of minimal length. SLS has applications in data compression, where a superstring is a compact representation of P, and in bioinformatics where it models the first step of genome assembly. Unfortunately SLS is hard to solve (NP-hard) and to closely approximate (MAX-SNP-hard). If numerous polynomial time approximation algorithms have been devised, few articles report on their practical performance. We lack knowledge about how closely an approximate superstring can be from an optimal one in practice. Here, we exhibit a linear time algorithm that reports an upper and a lower bound on the length of an optimal superstring. The upper bound is the length of an approximate superstring. This algorithm can be used to evaluate beforehand whether one can get an approximate superstring whose length is close to the optimum for a given instance. Experimental results suggest that its approximation performance is orders of magnitude better than previously reported practical values. Moreover, the proposed algorithm remainso efficient even on large instances and can serve to explore in practice the approximability of SLS.
Cite as

Bastien Cazaux, Samuel Juhel, and Eric Rivals. Practical lower and upper bounds for the Shortest Linear Superstring. In 17th International Symposium on Experimental Algorithms (SEA 2018). Leibniz International Proceedings in Informatics (LIPIcs), Volume 103, pp. 18:1-18:14, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2018)

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@InProceedings{cazaux_et_al:LIPIcs.SEA.2018.18,
  author =	{Cazaux, Bastien and Juhel, Samuel and Rivals, Eric},
  title =	{{Practical lower and upper bounds for the Shortest Linear Superstring}},
  booktitle =	{17th International Symposium on Experimental Algorithms (SEA 2018)},
  pages =	{18:1--18:14},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-070-5},
  ISSN =	{1868-8969},
  year =	{2018},
  volume =	{103},
  editor =	{D'Angelo, Gianlorenzo},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.SEA.2018.18},
  URN =		{urn:nbn:de:0030-drops-89530},
  doi =		{10.4230/LIPIcs.SEA.2018.18},
  annote =	{Keywords: greedy, approximation, overlap, Concat-Cycles, cyclic cover, linear time, text compression}
}
Document
DOI: 10.4230/LIPIcs.CPM.2018.21
Superstrings with multiplicities

Authors: Bastien Cazaux and Eric Rivals

Published in: LIPIcs, Volume 105, 29th Annual Symposium on Combinatorial Pattern Matching (CPM 2018)

Abstract
A superstring of a set of words P = {s_1, ..., s_p } is a string that contains each word of P as substring. Given P, the well known Shortest Linear Superstring problem (SLS), asks for a shortest superstring of P. In a variant of SLS, called Multi-SLS, each word s_i comes with an integer m(i), its multiplicity, that sets a constraint on its number of occurrences, and the goal is to find a shortest superstring that contains at least m(i) occurrences of s_i. Multi-SLS generalizes SLS and is obviously as hard to solve, but it has been studied only in special cases (with words of length 2 or with a fixed number of words). The approximability of Multi-SLS in the general case remains open. Here, we study the approximability of Multi-SLS and that of the companion problem Multi-SCCS, which asks for a shortest cyclic cover instead of shortest superstring. First, we investigate the approximation of a greedy algorithm for maximizing the compression offered by a superstring or by a cyclic cover: the approximation ratio is 1/2 for Multi-SLS and 1 for Multi-SCCS. Then, we exhibit a linear time approximation algorithm, Concat-Greedy, and show it achieves a ratio of 4 regarding the superstring length. This demonstrates that for both measures Multi-SLS belongs to the class of APX problems.
Cite as

Bastien Cazaux and Eric Rivals. Superstrings with multiplicities. In 29th Annual Symposium on Combinatorial Pattern Matching (CPM 2018). Leibniz International Proceedings in Informatics (LIPIcs), Volume 105, pp. 21:1-21:16, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2018)

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@InProceedings{cazaux_et_al:LIPIcs.CPM.2018.21,
  author =	{Cazaux, Bastien and Rivals, Eric},
  title =	{{Superstrings with multiplicities}},
  booktitle =	{29th Annual Symposium on Combinatorial Pattern Matching (CPM 2018)},
  pages =	{21:1--21:16},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-074-3},
  ISSN =	{1868-8969},
  year =	{2018},
  volume =	{105},
  editor =	{Navarro, Gonzalo and Sankoff, David and Zhu, Binhai},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.CPM.2018.21},
  URN =		{urn:nbn:de:0030-drops-86881},
  doi =		{10.4230/LIPIcs.CPM.2018.21},
  annote =	{Keywords: greedy algorithm, approximation, overlap, cyclic cover, APX, subset system}
}
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