97 Search Results for "Pisanti, Nadia"

Volume

LIPIcs, Volume 172

20th International Workshop on Algorithms in Bioinformatics (WABI 2020)

WABI 2020, September 7-9, 2020, Pisa, Italy (Virtual Conference)

Editors: Carl Kingsford and Nadia Pisanti

Volume

LIPIcs, Volume 128

30th Annual Symposium on Combinatorial Pattern Matching (CPM 2019)

CPM 2019, June 18-20, 2019, Pisa, Italy

Editors: Nadia Pisanti and Solon P. Pissis

Document
DOI: 10.4230/LIPIcs.STACS.2026.36
Time-Optimal Construction of String Synchronizing Sets

Authors: Jonas Ellert and Tomasz Kociumaka

Published in: LIPIcs, Volume 364, 43rd International Symposium on Theoretical Aspects of Computer Science (STACS 2026)

Abstract
A powerful design principle behind many modern string algorithms is local consistency: breaking the symmetry between string positions based on their small contexts so that matching fragments are handled consistently. Among the most influential instantiations of this principle are string synchronizing sets [Kempa & Kociumaka; STOC 2019]. A τ-synchronizing set of a string of length n is a set of O(n/τ) string positions, chosen using their length-2τ contexts, such that (outside of highly periodic regions) every block of τ consecutive positions contains at least one element of the set. Synchronizing sets have found dozens of applications in diverse settings, from quantum and dynamic algorithms to fully compressed computation. In the classic word RAM model, particularly for strings over small alphabets, they enabled faster solutions to core problems in data compression, text indexing, and string similarity. In this work, we show that any string T ∈ [0 .. σ)ⁿ can be preprocessed in O(n log σ / log n) time so that, for any given integer τ ∈ [1 .. n], a τ-synchronizing set of T can be constructed in O((n log τ)/(τ log n)) time. Both bounds are optimal in the word RAM model with machine word size w = Θ(log n), matching the information-theoretic minimum for the input and output sizes, respectively. Previously, constructing a τ-synchronizing set required O(n/τ) time after an O(n)-time preprocessing [Kociumaka, Radoszewski, Rytter, and Waleń; SICOMP 2024], or, in the restricted regime of τ < 0.2 log_σ n, without any preprocessing needed [Kempa & Kociumaka; STOC 2019]. A simple instantiation of our method outputs the synchronizing set as a sorted list in O(n/τ) time, or as a bitmask in O(n/log n) time. Our optimal construction produces a compact fully indexable dictionary, supporting select queries in O(1) time and rank queries in O(log ((log τ)/(log log n))) time. The latter complexity matches known unconditional cell-probe lower bounds for τ ≤ n^{1-Ω(1)}. To achieve this, we introduce a general framework for efficiently processing sparse integer sequences via a custom variable-length encoding. We also augment the optimal variant of van Emde Boas trees [Pătraşcu & Thorup; STOC 2006] with a deterministic linear-time construction. When the set is represented as a bitmask under our sparse encoding, the same guarantees for select and rank queries hold after preprocessing in time proportional to the size of our encoding (in words).
Cite as

Jonas Ellert and Tomasz Kociumaka. Time-Optimal Construction of String Synchronizing Sets. In 43rd International Symposium on Theoretical Aspects of Computer Science (STACS 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 364, pp. 36:1-36:22, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{ellert_et_al:LIPIcs.STACS.2026.36,
  author =	{Ellert, Jonas and Kociumaka, Tomasz},
  title =	{{Time-Optimal Construction of String Synchronizing Sets}},
  booktitle =	{43rd International Symposium on Theoretical Aspects of Computer Science (STACS 2026)},
  pages =	{36:1--36:22},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-412-3},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{364},
  editor =	{Mahajan, Meena and Manea, Florin and McIver, Annabelle and Thắng, Nguy\~{ê}n Kim},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.STACS.2026.36},
  URN =		{urn:nbn:de:0030-drops-255258},
  doi =		{10.4230/LIPIcs.STACS.2026.36},
  annote =	{Keywords: synchronizing sets, local consistency, packed strings}
}
Document
DOI: 10.4230/LIPIcs.IPEC.2025.8
Binary k-Center with Missing Entries: Structure Leads to Tractability

Authors: Tobias Friedrich, Kirill Simonov, and Farehe Soheil

Published in: LIPIcs, Volume 358, 20th International Symposium on Parameterized and Exact Computation (IPEC 2025)

Abstract
k-Center clustering is a fundamental classification problem, where the task is to categorize the given collection of entities into k clusters and come up with a representative for each cluster, so that the maximum distance between an entity and its representative is minimized. In this work, we focus on the setting where the entities are represented by binary vectors with missing entries, which model incomplete categorical data. This version of the problem has wide applications, from predictive analytics to bioinformatics. Our main finding is that the problem, which is notoriously hard from the classical complexity viewpoint, becomes tractable as soon as the known entries are sparse and exhibit a certain structure. Formally, we show fixed-parameter tractable algorithms for the parameters vertex cover, fracture number, and treewidth of the row-column graph, which encodes the positions of the known entries of the matrix. Additionally, we tie the complexity of the 1-cluster variant of the problem, which is famous under the name Closest String, to the complexity of solving integer linear programs with few constraints. This implies, in particular, that improving upon the running times of our algorithms would lead to more efficient algorithms for integer linear programming in general.
Cite as

Tobias Friedrich, Kirill Simonov, and Farehe Soheil. Binary k-Center with Missing Entries: Structure Leads to Tractability. In 20th International Symposium on Parameterized and Exact Computation (IPEC 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 358, pp. 8:1-8:19, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{friedrich_et_al:LIPIcs.IPEC.2025.8,
  author =	{Friedrich, Tobias and Simonov, Kirill and Soheil, Farehe},
  title =	{{Binary k-Center with Missing Entries: Structure Leads to Tractability}},
  booktitle =	{20th International Symposium on Parameterized and Exact Computation (IPEC 2025)},
  pages =	{8:1--8:19},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-407-9},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{358},
  editor =	{Agrawal, Akanksha and van Leeuwen, Erik Jan},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.IPEC.2025.8},
  URN =		{urn:nbn:de:0030-drops-251403},
  doi =		{10.4230/LIPIcs.IPEC.2025.8},
  annote =	{Keywords: Clustering, Missing Entries, k-Center, Parameterized Algorithms}
}
Document
DOI: 10.4230/LIPIcs.WABI.2025.17
An Efficient Data Structure and Algorithm for Long-Match Query in Run-Length Compressed BWT

Authors: Ahsan Sanaullah, Degui Zhi, and Shaojie Zhang

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)

Abstract
String matching problems in bioinformatics are typically for finding exact substring matches between a query and a reference text. Previous formulations often focus on maximum exact matches (MEMs). However, multiple occurrences of substrings of the query in the text that are long enough but not maximal may not be captured by MEMs. Such long matches can be informative, especially when the text is a collection of similar sequences such as genomes. In this paper, we describe a new type of match between a pattern and a text that aren't necessarily maximal in the query, but still contain useful matching information: locally maximal exact matches (LEMs). There are usually a large amount of LEMs, so we only consider those above some length threshold ℒ. These are referred to as long LEMs. The purpose of long LEMs is to capture substring matches between a query and a text that are not necessarily maximal in the pattern but still long enough to be important. Therefore efficient long LEMs finding algorithms are desired for these datasets. However, these datasets are too large to query on traditional string indexes. Fortunately, these datasets are very repetitive. Recently, compressed string indexes that take advantage of the redundancy in the data but retain efficient querying capability have been proposed as a solution. We therefore give an efficient algorithm for computing all the long LEMs of a query and a text in a BWT runs compressed string index. We describe an O(m+occ) expected time algorithm that relies on an O(r) words space string index for outputting all long LEMs of a pattern with respect to a text given the matching statistics of the pattern with respect to the text. Here m is the length of the query, occ is the number of long LEMs outputted, and r is the number of runs in the BWT of the text. The O(r) space string index we describe relies on an adaptation of the move data structure by Nishimoto and Tabei. We are able to support LCP[i] queries in constant time given SA[i]. In other words, we answer PLCP[i] queries in constant time. These PLCP queries enable the efficient long LEM query. Long LEMs may provide useful similarity information between a pattern and a text that MEMs may ignore. This information is particularly useful in pangenome and biobank scale haplotype panel contexts.
Cite as

Ahsan Sanaullah, Degui Zhi, and Shaojie Zhang. An Efficient Data Structure and Algorithm for Long-Match Query in Run-Length Compressed BWT. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 17:1-17:25, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{sanaullah_et_al:LIPIcs.WABI.2025.17,
  author =	{Sanaullah, Ahsan and Zhi, Degui and Zhang, Shaojie},
  title =	{{An Efficient Data Structure and Algorithm for Long-Match Query in Run-Length Compressed BWT}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{17:1--17:25},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.17},
  URN =		{urn:nbn:de:0030-drops-239433},
  doi =		{10.4230/LIPIcs.WABI.2025.17},
  annote =	{Keywords: BWT, LEM, Long LEM, MEM, Run Length Compressed BWT, Move Data Structure, Pangenome}
}
Document
DOI: 10.4230/LIPIcs.WABI.2025.16
Estimation of Substitution and Indel Rates via k-mer Statistics

Authors: Mahmudur Rahman Hera, Paul Medvedev, David Koslicki, and Antonio Blanca

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)

Abstract
Methods utilizing k-mers are widely used in bioinformatics, yet our understanding of their statistical properties under realistic mutation models remains incomplete. Previously, substitution-only mutation models have been considered to derive precise expectations and variances for mutated k-mers and intervals of mutated and non-mutated sequences. In this work, we consider a mutation model that incorporates insertions and deletions in addition to single-nucleotide substitutions. Within this framework, we derive closed-form k-mer-based estimators for the three fundamental mutation parameters: substitution, deletion rate, and insertion rates. We provide theoretical guarantees in the form of concentration inequalities, ensuring accuracy of our estimators under reasonable model assumptions. Empirical evaluations on simulated evolution of genomic sequences confirm our theoretical findings, demonstrating that accounting for insertions and deletions signals allows for accurate estimation of mutation rates and improves upon the results obtained by considering a substitution-only model. An implementation of estimating the mutation parameters from a pair of fasta files is available here: https://github.com/KoslickiLab/estimate_rates_using_mutation_model.git. The results presented in this manuscript can be reproduced using the code available here: https://github.com/KoslickiLab/est_rates_experiments.git.
Cite as

Mahmudur Rahman Hera, Paul Medvedev, David Koslicki, and Antonio Blanca. Estimation of Substitution and Indel Rates via k-mer Statistics. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 16:1-16:15, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{rahmanhera_et_al:LIPIcs.WABI.2025.16,
  author =	{Rahman Hera, Mahmudur and Medvedev, Paul and Koslicki, David and Blanca, Antonio},
  title =	{{Estimation of Substitution and Indel Rates via k-mer Statistics}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{16:1--16:15},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.16},
  URN =		{urn:nbn:de:0030-drops-239422},
  doi =		{10.4230/LIPIcs.WABI.2025.16},
  annote =	{Keywords: k-mers, mutation rate, indel, alignment-free, estimation, substitution, insertion, deletion}
}
Document
DOI: 10.4230/LIPIcs.WABI.2025.3
Approximability of Longest Run Subsequence and Complementary Minimization Problems

Authors: Yuichi Asahiro, Mingyang Gong, Jesper Jansson, Guohui Lin, Sichen Lu, Eiji Miyano, Hirotaka Ono, Toshiki Saitoh, and Shunichi Tanaka

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)

Abstract
We study the polynomial-time approximability of the Longest Run Subsequence problem (LRS for short) and its complementary minimization variant Minimum Run Subsequence Deletion problem (MRSD for short). For a string S = s₁ ⋯ s_n over an alphabet Σ, a subsequence S' of S is S' = s_{i₁} ⋯ s_{i_p}, such that 1 ≤ i₁ < i₂ < … < i_p ≤ |S|. A run of a symbol σ ∈ Σ in S is a maximal substring of consecutive occurrences of σ. A run subsequence S' of S is a subsequence of S in which every symbol σ ∈ Σ occurs in at most one run. The co-subsequence ̅{S'} of the subsequence S' = s_{i₁} ⋯ s_{i_p} in S is the subsequence obtained by deleting all the characters in S' from S, i.e., ̅{S'} = s_{j₁} ⋯ s_{j_{n-p}} such that j₁ < j₂ < … < j_{n-p} and {j₁, …, j_{n-p}} = {1, …, n}⧵ {i₁, …, i_p}. Given a string S, the goal of LRS (resp., MRSD) is to find a run subsequence S^* of S such that the length |S^*| is maximized (resp., the number | ̅{S^*}| of deleted symbols from S is minimized) over all the run subsequences of S. Let k be the maximum number of symbol occurrences in the input S. It is known that LRS and MRSD are APX-hard even if k = 2. In this paper, we show that LRS can be approximated in polynomial time within factors of (k+2)/3 for k = 2 or 3, and 2(k+1)/5 for every k ≥ 4. Furthermore, we show that MRSD can be approximated in linear time within a factor of (k+4)/4 if k is even and (k+3)/4 if k is odd.
Cite as

Yuichi Asahiro, Mingyang Gong, Jesper Jansson, Guohui Lin, Sichen Lu, Eiji Miyano, Hirotaka Ono, Toshiki Saitoh, and Shunichi Tanaka. Approximability of Longest Run Subsequence and Complementary Minimization Problems. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 3:1-3:20, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{asahiro_et_al:LIPIcs.WABI.2025.3,
  author =	{Asahiro, Yuichi and Gong, Mingyang and Jansson, Jesper and Lin, Guohui and Lu, Sichen and Miyano, Eiji and Ono, Hirotaka and Saitoh, Toshiki and Tanaka, Shunichi},
  title =	{{Approximability of Longest Run Subsequence and Complementary Minimization Problems}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{3:1--3:20},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.3},
  URN =		{urn:nbn:de:0030-drops-239290},
  doi =		{10.4230/LIPIcs.WABI.2025.3},
  annote =	{Keywords: Longest run subsequence, minimum run subsequence deletion, approximation algorithm}
}
Document
DOI: 10.4230/LIPIcs.WABI.2025.4
Haplotype-Aware Long-Read Error Correction

Authors: Parvesh Barak, Daniel Gibney, and Chirag Jain

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)

Abstract
Error correction of long reads is an important initial step in genome assembly workflows. For organisms with ploidy greater than one, it is important to preserve haplotype-specific variation during read correction. This challenge has driven the development of several haplotype-aware correction methods. However, existing methods are based on either ad-hoc heuristics or deep learning approaches. In this paper, we introduce a rigorous formulation for this problem. Our approach builds on the minimum error correction framework used in reference-based haplotype phasing. We prove that the proposed formulation for error correction of reads in de novo context, i.e., without using a reference genome, is NP-hard. To make our exact algorithm scale to large datasets, we introduce practical heuristics. Experiments using PacBio HiFi sequencing datasets from human and plant genomes show that our approach achieves accuracy comparable to state-of-the-art methods. The software is freely available at https://github.com/at-cg/HALE.
Cite as

Parvesh Barak, Daniel Gibney, and Chirag Jain. Haplotype-Aware Long-Read Error Correction. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 4:1-4:20, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{barak_et_al:LIPIcs.WABI.2025.4,
  author =	{Barak, Parvesh and Gibney, Daniel and Jain, Chirag},
  title =	{{Haplotype-Aware Long-Read Error Correction}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{4:1--4:20},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.4},
  URN =		{urn:nbn:de:0030-drops-239300},
  doi =		{10.4230/LIPIcs.WABI.2025.4},
  annote =	{Keywords: Genome assembly, phasing, clustering, overlap graph, consensus}
}
Document
DOI: 10.4230/LIPIcs.WABI.2025.9
Dolphyin: A Combinatorial Algorithm for Identifying 1-Dollo Phylogenies in Cancer

Authors: Daniel W. Feng and Mohammed El-Kebir

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)

Abstract
Several recent cancer phylogeny inference methods have used the k-Dollo evolutionary model for single-nucleotide variants. Specifically, in this problem one is given an m × n binary matrix B and seeks a rooted tree T with m leaves that correspond to the m rows of B, and each node of T is labeled by a binary state for each of the n characters subject to the restriction that each character is gained at most once (0-to-1 transition) and subsequently lost at most k times (1-to-0 transitions). The 1-Dollo variant, also known as the persistent perfect phylogeny where one is restricted to at most k = 1 losses per character, has been studied extensively, but its hardness remains an open question. Here, we prove that the 1-Dollo Linear Phylogeny (1DLP) problem, where we additionally require the resulting 1-Dollo phylogeny T to be linear, is equivalent to verifying whether the input matrix B adheres to the Consecutive Ones Property (C1P), which can be solved in polynomial time. Due to the equivalence, several known NP-hardness results for relevant variants of C1P carry over to 1DLP, including the minimization of false negatives (0-to-1 modifications to the input matrix B) or the allowance of 2 gains and 2 losses. We furthermore show how we can recursively decompose any, not necessarily linear, 1-Dollo phylogeny T into several 1-Dollo linear phylogenies, connected by matching branching points. We extend this characterization to matrices B that admit 1-Dollo phylogenies, giving necessary and sufficient conditions for the existence of a novel decomposition of B into several submatrices and corresponding branching points. This decomposition forms the basis of Dolphyin, a new exponential-time algorithm for inferring 1-Dollo phylogenies that efficiently leverages the determination of linear 1-Dollo phylogenies as a subroutine. Dolphyin can also be applied to input matrices B with false negatives. We demonstrate that Dolphyin is runtime-competitive with a previous integer linear programming based algorithm SPhyR on simulated datasets. We additionally analyze simulated datasets with false negative errors and find that in the median case, Dolphyin infers 1-Dollo phylogenies with inferred error rates at or below the ground truth rate. Finally, we apply Dolphyin to 99 acute myeloid leukemia single-cell sequencing datasets, finding that the majority of the cancers can be explained by 1-Dollo phylogenies with false negative error rates in line with the used sequencing technology. Availability. Dolphyin is available at: https://github.com/elkebir-group/Dolphyin.
Cite as

Daniel W. Feng and Mohammed El-Kebir. Dolphyin: A Combinatorial Algorithm for Identifying 1-Dollo Phylogenies in Cancer. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 9:1-9:23, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{feng_et_al:LIPIcs.WABI.2025.9,
  author =	{Feng, Daniel W. and El-Kebir, Mohammed},
  title =	{{Dolphyin: A Combinatorial Algorithm for Identifying 1-Dollo Phylogenies in Cancer}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{9:1--9:23},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.9},
  URN =		{urn:nbn:de:0030-drops-239356},
  doi =		{10.4230/LIPIcs.WABI.2025.9},
  annote =	{Keywords: Intra-tumor heterogeneity, persistent perfect phylogeny, consecutive ones property, combinatorics}
}
Document
Research
DOI: 10.4230/OASIcs.Grossi.2
On the Construction of Elastic Degenerate Strings

Authors: Nicola Rizzo, Veli Mäkinen, and Nadia Pisanti

Published in: OASIcs, Volume 132, From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday (2025)

Abstract
An elastic degenerate string (EDS) is a sequence of sets of strings. In the context of bioinformatics, EDSes can be used to represent the variations observed in a population from its consensus genome. Pattern matching and comparison problems on EDSes have been widely studied in the literature, but their construction has been largely omitted. We fill this gap by showing how algorithms originally developed for related problems of founder reconstruction can be adapted to minimize the total cardinality of the EDS sets and total length of the EDS strings in linear time, given suitable multiple alignments representing the input data.
Cite as

Nicola Rizzo, Veli Mäkinen, and Nadia Pisanti. On the Construction of Elastic Degenerate Strings. In From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 132, pp. 2:1-2:13, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{rizzo_et_al:OASIcs.Grossi.2,
  author =	{Rizzo, Nicola and M\"{a}kinen, Veli and Pisanti, Nadia},
  title =	{{On the Construction of Elastic Degenerate Strings}},
  booktitle =	{From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday},
  pages =	{2:1--2:13},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-391-1},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{132},
  editor =	{Conte, Alessio and Marino, Andrea and Rosone, Giovanna and Vitter, Jeffrey Scott},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Grossi.2},
  URN =		{urn:nbn:de:0030-drops-238014},
  doi =		{10.4230/OASIcs.Grossi.2},
  annote =	{Keywords: multiple sequence alignment, pattern matching, data structures, segmentation algorithms, founder reconstruction, dynamic programming, semi-dynamic range minimum queries, positional Burrows-Wheeler transform}
}
Document
Research
DOI: 10.4230/OASIcs.Grossi.14
Specific Patterns Against Reference Sequences

Authors: Marie-Pierre Béal and Maxime Crochemore

Published in: OASIcs, Volume 132, From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday (2025)

Abstract
We design alignment-free techniques for comparing a set of sequences or just a word, called a target, against another set of words, called a reference. This is done with the detection of factor patterns that distinguish the target from the reference. A target-specific factor of a target T against a reference R is then a factor w of a word in T that is not a factor of a word in R but whose proper factors of w are factors of a word in R. The strategy is based on the notion of minimal absent/forbidden words. We first address the computation of the set of target-specific factors of a target T against a reference R, where T and R are finite sets of sequences. The result is the construction of an automaton accepting the set of all considered target-specific factors. The construction algorithm runs in linear time according to the size of T ∪ R. The second result is the design of an algorithm to compute all the occurrences in a single sequence T of its target-specific factors against a reference R. The algorithm runs in real-time on the target sequence, independently of the number of occurrences of target-specific factors.
Cite as

Marie-Pierre Béal and Maxime Crochemore. Specific Patterns Against Reference Sequences. In From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 132, pp. 14:1-14:12, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{beal_et_al:OASIcs.Grossi.14,
  author =	{B\'{e}al, Marie-Pierre and Crochemore, Maxime},
  title =	{{Specific Patterns Against Reference Sequences}},
  booktitle =	{From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday},
  pages =	{14:1--14:12},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-391-1},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{132},
  editor =	{Conte, Alessio and Marino, Andrea and Rosone, Giovanna and Vitter, Jeffrey Scott},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Grossi.14},
  URN =		{urn:nbn:de:0030-drops-238130},
  doi =		{10.4230/OASIcs.Grossi.14},
  annote =	{Keywords: Specific pattern, Minimal absent word, Minimal forbidden word, Directed Acyclic Word Graph (DAWG), Suffix automaton}
}
Document
Research
DOI: 10.4230/OASIcs.Grossi.9
On String and Graph Sanitization

Authors: Giulia Bernardini, Huiping Chen, Grigorios Loukides, and Solon P. Pissis

Published in: OASIcs, Volume 132, From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday (2025)

Abstract
Data sanitization is a process that conceals sensitive patterns from a given dataset. A secondary goal is to not severely harm the utility of the underlying data along this process. We survey some recent advancements on two related data sanitization topics: string and graph sanitization. In particular, we highlight the important contributions of our friend Prof. Roberto Grossi along this journey.
Cite as

Giulia Bernardini, Huiping Chen, Grigorios Loukides, and Solon P. Pissis. On String and Graph Sanitization. In From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 132, pp. 9:1-9:10, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{bernardini_et_al:OASIcs.Grossi.9,
  author =	{Bernardini, Giulia and Chen, Huiping and Loukides, Grigorios and Pissis, Solon P.},
  title =	{{On String and Graph Sanitization}},
  booktitle =	{From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday},
  pages =	{9:1--9:10},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-391-1},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{132},
  editor =	{Conte, Alessio and Marino, Andrea and Rosone, Giovanna and Vitter, Jeffrey Scott},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Grossi.9},
  URN =		{urn:nbn:de:0030-drops-238086},
  doi =		{10.4230/OASIcs.Grossi.9},
  annote =	{Keywords: data privacy, data sanitization, string algorithms, graph algorithms}
}
Document
Research
DOI: 10.4230/OASIcs.Grossi.19
Designing Output Sensitive Algorithms for Subgraph Enumeration

Authors: Alessio Conte, Kazuhiro Kurita, Andrea Marino, Giulia Punzi, Takeaki Uno, and Kunihiro Wasa

Published in: OASIcs, Volume 132, From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday (2025)

Abstract
The enumeration of all subgraphs respecting some structural property is a fundamental task in theoretical computer science, with practical applications in many branches of data mining and network analysis. It is often of interest to only consider solutions (subgraphs) that are maximal under inclusion, and to achieve output-sensitive complexity, i.e., bounding the running time with respect to the number of subgraphs produced. In this paper, we provide a survey of techniques for designing output-sensitive algorithms for subgraph enumeration, including partition-based approaches such as flashlight search, solution-graph traversal methods such as reverse search, and cost amortization strategies such as push-out amortization. We also briefly discuss classes of efficiency, hardness of enumeration, and variants such as approximate enumeration. The paper is meant as an accessible handbook for learning the basics of the field and as a practical reference for selecting state-of-the-art subgraph enumeration strategies fitting to one’s needs.
Cite as

Alessio Conte, Kazuhiro Kurita, Andrea Marino, Giulia Punzi, Takeaki Uno, and Kunihiro Wasa. Designing Output Sensitive Algorithms for Subgraph Enumeration. In From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 132, pp. 19:1-19:40, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{conte_et_al:OASIcs.Grossi.19,
  author =	{Conte, Alessio and Kurita, Kazuhiro and Marino, Andrea and Punzi, Giulia and Uno, Takeaki and Wasa, Kunihiro},
  title =	{{Designing Output Sensitive Algorithms for Subgraph Enumeration}},
  booktitle =	{From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday},
  pages =	{19:1--19:40},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-391-1},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{132},
  editor =	{Conte, Alessio and Marino, Andrea and Rosone, Giovanna and Vitter, Jeffrey Scott},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Grossi.19},
  URN =		{urn:nbn:de:0030-drops-238180},
  doi =		{10.4230/OASIcs.Grossi.19},
  annote =	{Keywords: Graph algorithms, Graph enumeration, Output sensitive enumeration}
}
Document
Research
DOI: 10.4230/OASIcs.Grossi.20
Subsequence-Based Indices for Genome Sequence Analysis

Authors: Giovanni Buzzega, Alessio Conte, Veronica Guerrini, Giulia Punzi, Giovanna Rosone, and Lorenzo Tattini

Published in: OASIcs, Volume 132, From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday (2025)

Abstract
Compact indices are a fundamental tool in string analysis, even more so in bioinformatics, where genomic sequences can reach billions in length. This paper presents some recent results in which Roberto Grossi has been involved, showing how some of these indices do more than just efficiently represent data, but rather are able to bring out salient information within it, which can be exploited for their downstream analysis. Specifically, we first review a recently-introduced method [Guerrini et al., 2023] that employs the Burrows-Wheeler Transform to build reasonably accurate phylogenetic trees in an assembly-free scenario. We then describe a recent practical tool [Buzzega et al., 2025] for indexing Maximal Common Subsequences between strings, which can enable analysis of genomic sequence similarity. Experimentally, we show that the results produced by the one index are consistent with the expectations about the results of the other index.
Cite as

Giovanni Buzzega, Alessio Conte, Veronica Guerrini, Giulia Punzi, Giovanna Rosone, and Lorenzo Tattini. Subsequence-Based Indices for Genome Sequence Analysis. In From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 132, pp. 20:1-20:21, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{buzzega_et_al:OASIcs.Grossi.20,
  author =	{Buzzega, Giovanni and Conte, Alessio and Guerrini, Veronica and Punzi, Giulia and Rosone, Giovanna and Tattini, Lorenzo},
  title =	{{Subsequence-Based Indices for Genome Sequence Analysis}},
  booktitle =	{From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday},
  pages =	{20:1--20:21},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-391-1},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{132},
  editor =	{Conte, Alessio and Marino, Andrea and Rosone, Giovanna and Vitter, Jeffrey Scott},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Grossi.20},
  URN =		{urn:nbn:de:0030-drops-238199},
  doi =		{10.4230/OASIcs.Grossi.20},
  annote =	{Keywords: String Indices, Burrows-Wheeler Transform, Maximal Common Subsequences, Sequence Analysis, Phylogeny}
}
Document
Research
DOI: 10.4230/OASIcs.Grossi.18
DNA Is a Puzzle Enthusiast

Authors: Roberto Marangoni

Published in: OASIcs, Volume 132, From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday (2025)

Abstract
This article presents a concise summary of research projects in which Roberto Grossi participated, yielding interesting results that were never previously published in research papers. At the time, these studies were deemed too limited and in need of further extensions and generalizations, which were never realized due to a lack of resources. The researches focused on methods for inferring possible three-dimensional DNA conformations based on nucleotide sequence characteristics. Specifically, two key approaches were investigated: the identification of structured motifs for detecting Transcription Factor Binding Sites (TFBS) and the study of nested permutations using PQ-trees. This article describes the obtained results in selected case studies, their potential implications, and the current state of the art in these research areas.
Cite as

Roberto Marangoni. DNA Is a Puzzle Enthusiast. In From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 132, pp. 18:1-18:8, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{marangoni:OASIcs.Grossi.18,
  author =	{Marangoni, Roberto},
  title =	{{DNA Is a Puzzle Enthusiast}},
  booktitle =	{From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday},
  pages =	{18:1--18:8},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-391-1},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{132},
  editor =	{Conte, Alessio and Marino, Andrea and Rosone, Giovanna and Vitter, Jeffrey Scott},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Grossi.18},
  URN =		{urn:nbn:de:0030-drops-238172},
  doi =		{10.4230/OASIcs.Grossi.18},
  annote =	{Keywords: DNA, 3D structure, PQ trees, structural motifs}
}
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