52 Search Results for "Sung, Wing-Kin"

Volume

LIPIcs, Volume 312

24th International Workshop on Algorithms in Bioinformatics (WABI 2024)

WABI 2024, September 2-4, 2024, Royal Holloway, London, United Kingdom

Editors: Solon P. Pissis and Wing-Kin Sung

Document
DOI: 10.4230/LIPIcs.SEA.2026.7
From Relative Compression to Hierarchical Compression

Authors: Philip Bille, Inge Li Gørtz, and Máximo Pérez-López

Published in: LIPIcs, Volume 371, 24th International Symposium on Experimental Algorithms (SEA 2026)

Abstract
We introduce a framework to use any relative compression algorithm as a subroutine for hierarchical relative compression. In a dataset consisting of n sequences, it consists of constructing a rooted tree on the sequences, using hashing and similarity techniques, and compressing the children of a node relative to their parent. We build up on previous techniques [Bille et al., 2023], and optimize them further for computational efficiency. We test our framework with three existing relative compression algorithms on six genomic datasets, and we show that in datasets that contain heterogeneous data, hierarchical relative compression improves the compression ratio by a factor 2 or more, when compared to relative compression to a single sequence. Apart from compression ratio, we also explore the trade-offs with respect to compression speed, dataset decompression speed, and average sequence decompression speed. With two of the surveyed algorithms, dataset decompression becomes faster and sequence decompression remains practical, at the cost of compression time, which remains competitive for the datasets with highest variability.
Cite as

Philip Bille, Inge Li Gørtz, and Máximo Pérez-López. From Relative Compression to Hierarchical Compression. In 24th International Symposium on Experimental Algorithms (SEA 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 371, pp. 7:1-7:18, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{bille_et_al:LIPIcs.SEA.2026.7,
  author =	{Bille, Philip and G{\o}rtz, Inge Li and P\'{e}rez-L\'{o}pez, M\'{a}ximo},
  title =	{{From Relative Compression to Hierarchical Compression}},
  booktitle =	{24th International Symposium on Experimental Algorithms (SEA 2026)},
  pages =	{7:1--7:18},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-422-2},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{371},
  editor =	{Aum\"{u}ller, Martin and Finocchi, Irene},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.SEA.2026.7},
  URN =		{urn:nbn:de:0030-drops-260117},
  doi =		{10.4230/LIPIcs.SEA.2026.7},
  annote =	{Keywords: Relative compression, RLZ, string collections, compressed representation, data structures, efficient algorithms}
}
Document
DOI: 10.4230/LIPIcs.SEA.2026.10
Compressing Highly Repetitive Binary Trees with an Application to Range Minimum Queries

Authors: Gabriel Carmona and Filippo Lari

Published in: LIPIcs, Volume 371, 24th International Symposium on Experimental Algorithms (SEA 2026)

Abstract
Tree compression is a well-studied area that aims at reducing the size of tree representations by exploiting different forms of repetition. While the underlying theory is well understood, there is still significant room for experimental investigation, particularly in the design of compressed representations that efficiently support navigational queries. In this work, we address the problem of designing, engineering, and experimentally evaluating a compression technique for unlabeled binary trees based on repeated subtrees, yielding the minimal Directed Acyclic Graph (DAG) of the input tree. We show how this representation can be computed in linear time and space directly from a succinct encoding of the tree, and how it can be augmented with compact auxiliary data structures to support Lowest Common Ancestor (LCA) queries. When the input tree is the Cartesian tree of an array, LCA queries can be used to answer Range Minimum Queries (RMQs) on the underlying array. This is particularly relevant in the encoding model, where the array is not accessible at query time, and a space lower bound of 2n-O(log n) bits is known. Given the numerous applications of RMQs, we use this problem as a case study for our experimental evaluation, testing our implementation on 11 real-world datasets. Our experiments show that, on almost every dataset, our implementation is the most space-efficient, using as few as 0.11n bits, while still delivering practical query times.
Cite as

Gabriel Carmona and Filippo Lari. Compressing Highly Repetitive Binary Trees with an Application to Range Minimum Queries. In 24th International Symposium on Experimental Algorithms (SEA 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 371, pp. 10:1-10:20, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{carmona_et_al:LIPIcs.SEA.2026.10,
  author =	{Carmona, Gabriel and Lari, Filippo},
  title =	{{Compressing Highly Repetitive Binary Trees with an Application to Range Minimum Queries}},
  booktitle =	{24th International Symposium on Experimental Algorithms (SEA 2026)},
  pages =	{10:1--10:20},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-422-2},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{371},
  editor =	{Aum\"{u}ller, Martin and Finocchi, Irene},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.SEA.2026.10},
  URN =		{urn:nbn:de:0030-drops-260140},
  doi =		{10.4230/LIPIcs.SEA.2026.10},
  annote =	{Keywords: tree compression, range minimum query, compact data structures, algorithm engineering, experimental evaluation}
}
Document
DOI: 10.4230/LIPIcs.STACS.2026.62
Relative Compressed Reverse Suffix Array

Authors: Muhammed Oguzhan Kulekci, Mano Prakash Parthasarathi, Rahul Shah, and Sharma V. Thankachan

Published in: LIPIcs, Volume 364, 43rd International Symposium on Theoretical Aspects of Computer Science (STACS 2026)

Abstract
Suffix trees and suffix arrays are two fundamental data structures in the field of string algorithms. For a string (a.k.a. text or sequence) of length n over an alphabet of size σ, these structures typically require O(nlog n) bits of space. The FM-index provides a compressed representation of the suffix array in ≈ nlog σ bits, allowing for efficient queries on both the suffix array and its inverse array in near logarithmic time. In certain applications, such as approximate pattern matching (i.e., with wildcards, mismatches, edits), there is a need to access the suffix array of a text, as well as the suffix array of text’s reverse. Motivated by this, we explore the possibility of encoding the suffix array of the reversed text in a compact form, assuming the availability of the FM-index for the original text. Our first solution is an O(n)-bit (relative) encoding of the suffix array of the reversed text, with the time for decoding an entry being only O(log^*n) times that of decoding an entry in the text’s suffix array using FM-index. We then demonstrate how to reduce the space to O(n/κ) bits for a parameter κ, while multiplicative factor in time becomes approximately O(κlog^*n+κ³). We can also support inverse suffix array and longest common extension queries on the reversed text. These results are achieved through some careful and non-trivial application of various succinct data structure techniques.
Cite as

Muhammed Oguzhan Kulekci, Mano Prakash Parthasarathi, Rahul Shah, and Sharma V. Thankachan. Relative Compressed Reverse Suffix Array. In 43rd International Symposium on Theoretical Aspects of Computer Science (STACS 2026). Leibniz International Proceedings in Informatics (LIPIcs), Volume 364, pp. 62:1-62:21, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2026)

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@InProceedings{kulekci_et_al:LIPIcs.STACS.2026.62,
  author =	{Kulekci, Muhammed Oguzhan and Parthasarathi, Mano Prakash and Shah, Rahul and Thankachan, Sharma V.},
  title =	{{Relative Compressed Reverse Suffix Array}},
  booktitle =	{43rd International Symposium on Theoretical Aspects of Computer Science (STACS 2026)},
  pages =	{62:1--62:21},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-412-3},
  ISSN =	{1868-8969},
  year =	{2026},
  volume =	{364},
  editor =	{Mahajan, Meena and Manea, Florin and McIver, Annabelle and Thắng, Nguy\~{ê}n Kim},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.STACS.2026.62},
  URN =		{urn:nbn:de:0030-drops-255512},
  doi =		{10.4230/LIPIcs.STACS.2026.62},
  annote =	{Keywords: String Matching, Text Indexing, Data Structures, Suffix Trees}
}
Document
DOI: 10.4230/LIPIcs.FSTTCS.2025.43
A Finer View of the Parameterized Landscape of Labeled Graph Contractions

Authors: Yashaswini Mathur and Prafullkumar Tale

Published in: LIPIcs, Volume 360, 45th IARCS Annual Conference on Foundations of Software Technology and Theoretical Computer Science (FSTTCS 2025)

Abstract
We study the Labeled Contractibility problem, where the input consists of two vertex-labeled graphs G and H, and the goal is to determine whether H can be obtained from G via a sequence of edge contractions. Lafond and Marchand [WADS 2025] initiated the parameterized complexity study of this problem, showing it to be W[1]-hard when parameterized by the number k of allowed contractions. They also proved that the problem is fixed-parameter tractable when parameterized by the tree-width tw of G, via an application of Courcelle’s theorem resulting in a non-constructive algorithm. In this work, we present a constructive fixed-parameter algorithm for Labeled Contractibility with running time 2^{𝒪(tw²)} ⋅ |V(G)|^{𝒪(1)}. We also prove that unless the Exponential Time Hypothesis ({ETH}) fails, it does not admit an algorithm running in time 2^{o(tw²)} ⋅ |V(G)|^{𝒪(1)}. This result adds Labeled Contractibility to a small list of problems that admit such a lower bound and matching algorithm. We further strengthen existing hardness results by showing that the problem remains NP-complete even when both input graphs have bounded maximum degree. We also investigate parameterizations by (k + δ(G)) where δ(G) denotes the degeneracy of G, and rule out the existence of subexponential-time algorithms. This answers question raised in Lafond and Marchand [WADS 2025]. We additionally provide an improved FPT algorithm with better dependence on (k + δ(G)) than previously known. Finally, we analyze a brute-force algorithm for Labeled Contractibility with running time |V(H)|^{𝒪(|V(G)|)}, and show that this running time is optimal under {ETH}.
Cite as

Yashaswini Mathur and Prafullkumar Tale. A Finer View of the Parameterized Landscape of Labeled Graph Contractions. In 45th IARCS Annual Conference on Foundations of Software Technology and Theoretical Computer Science (FSTTCS 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 360, pp. 43:1-43:19, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{mathur_et_al:LIPIcs.FSTTCS.2025.43,
  author =	{Mathur, Yashaswini and Tale, Prafullkumar},
  title =	{{A Finer View of the Parameterized Landscape of Labeled Graph Contractions}},
  booktitle =	{45th IARCS Annual Conference on Foundations of Software Technology and Theoretical Computer Science (FSTTCS 2025)},
  pages =	{43:1--43:19},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-406-2},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{360},
  editor =	{Aiswarya, C. and Mehta, Ruta and Roy, Subhajit},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.FSTTCS.2025.43},
  URN =		{urn:nbn:de:0030-drops-251237},
  doi =		{10.4230/LIPIcs.FSTTCS.2025.43},
  annote =	{Keywords: Labeled Contraction, ETH Lower-bound, Treewidth, NP-hard}
}
Document
DOI: 10.4230/LIPIcs.ESA.2025.55
Safe Sequences via Dominators in DAGs for Path-Covering Problems

Authors: Francisco Sena, Romeo Rizzi, and Alexandru I. Tomescu

Published in: LIPIcs, Volume 351, 33rd Annual European Symposium on Algorithms (ESA 2025)

Abstract
A path-covering problem on a directed acyclic graph (DAG) requires finding a set of source-to-sink paths that cover all the nodes, all the arcs, or subsets thereof, and additionally they are optimal with respect to some function. In this paper we study safe sequences of nodes or arcs, namely sequences that appear in some path of every path cover of a DAG. We show that safe sequences admit a simple characterization via cutnodes. Moreover, we establish a connection between maximal safe sequences and leaf-to-root paths in the source- and sink-dominator trees of the DAG, which may be of independent interest in the extensive literature on dominators. With dominator trees, safe sequences admit an O(n)-size representation and a linear-time output-sensitive enumeration algorithm running in time O(m + o), where n and m are the number of nodes and arcs, respectively, and o is the total length of the maximal safe sequences. We then apply maximal safe sequences to simplify Integer Linear Programs (ILPs) for two path-covering problems, LeastSquares and MinPathError, which are at the core of RNA transcript assembly problems from bioinformatics. On various datasets, maximal safe sequences can be computed in under 0.1 seconds per graph, on average, and ILP solvers whose search space is reduced in this manner exhibit significant speed-ups. For example on graphs with a large width, average speed-ups are in the range 50-250× for MinPathError and in the range 80-350× for LeastSquares. Optimizing ILPs using safe sequences can thus become a fast building block of practical RNA transcript assembly tools, and more generally, of path-covering problems.
Cite as

Francisco Sena, Romeo Rizzi, and Alexandru I. Tomescu. Safe Sequences via Dominators in DAGs for Path-Covering Problems. In 33rd Annual European Symposium on Algorithms (ESA 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 351, pp. 55:1-55:17, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{sena_et_al:LIPIcs.ESA.2025.55,
  author =	{Sena, Francisco and Rizzi, Romeo and Tomescu, Alexandru I.},
  title =	{{Safe Sequences via Dominators in DAGs for Path-Covering Problems}},
  booktitle =	{33rd Annual European Symposium on Algorithms (ESA 2025)},
  pages =	{55:1--55:17},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-395-9},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{351},
  editor =	{Benoit, Anne and Kaplan, Haim and Wild, Sebastian and Herman, Grzegorz},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.ESA.2025.55},
  URN =		{urn:nbn:de:0030-drops-245230},
  doi =		{10.4230/LIPIcs.ESA.2025.55},
  annote =	{Keywords: directed acyclic graph, path cover, dominator tree, integer linear programming, least squares, minimum path error}
}
Document
DOI: 10.4230/LIPIcs.WABI.2025.11
Mutational Signature Refitting on Sparse Pan-Cancer Data

Authors: Gal Gilad, Teresa M. Przytycka, and Roded Sharan

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)

Abstract
Mutational processes shape cancer genomes, leaving characteristic marks that are termed signatures. The level of activity of each such process, or its signature exposure, provides important information on the disease, improving patient stratification and the prediction of drug response. Thus, there is growing interest in developing refitting methods that decipher those exposures. Previous work in this domain was unsupervised in nature, employing algebraic decomposition and probabilistic inference methods. Here we provide a supervised approach to the problem of signature refitting and show its superiority over current methods. Our method, SuRe, leverages a neural network model to capture correlations between signature exposures in real data. We show that SuRe outperforms previous methods on sparse mutation data from tumor type specific data sets, as well as pan-cancer data sets, with an increasing advantage as the data become sparser. We further demonstrate its utility in clinical settings.
Cite as

Gal Gilad, Teresa M. Przytycka, and Roded Sharan. Mutational Signature Refitting on Sparse Pan-Cancer Data. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 11:1-11:23, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{gilad_et_al:LIPIcs.WABI.2025.11,
  author =	{Gilad, Gal and Przytycka, Teresa M. and Sharan, Roded},
  title =	{{Mutational Signature Refitting on Sparse Pan-Cancer Data}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{11:1--11:23},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.11},
  URN =		{urn:nbn:de:0030-drops-239374},
  doi =		{10.4230/LIPIcs.WABI.2025.11},
  annote =	{Keywords: mutational signatures, signature refitting, cancer genomics, genomic data analysis, somatic mutations}
}
Document
DOI: 10.4230/LIPIcs.WABI.2025.17
An Efficient Data Structure and Algorithm for Long-Match Query in Run-Length Compressed BWT

Authors: Ahsan Sanaullah, Degui Zhi, and Shaojie Zhang

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)

Abstract
String matching problems in bioinformatics are typically for finding exact substring matches between a query and a reference text. Previous formulations often focus on maximum exact matches (MEMs). However, multiple occurrences of substrings of the query in the text that are long enough but not maximal may not be captured by MEMs. Such long matches can be informative, especially when the text is a collection of similar sequences such as genomes. In this paper, we describe a new type of match between a pattern and a text that aren't necessarily maximal in the query, but still contain useful matching information: locally maximal exact matches (LEMs). There are usually a large amount of LEMs, so we only consider those above some length threshold ℒ. These are referred to as long LEMs. The purpose of long LEMs is to capture substring matches between a query and a text that are not necessarily maximal in the pattern but still long enough to be important. Therefore efficient long LEMs finding algorithms are desired for these datasets. However, these datasets are too large to query on traditional string indexes. Fortunately, these datasets are very repetitive. Recently, compressed string indexes that take advantage of the redundancy in the data but retain efficient querying capability have been proposed as a solution. We therefore give an efficient algorithm for computing all the long LEMs of a query and a text in a BWT runs compressed string index. We describe an O(m+occ) expected time algorithm that relies on an O(r) words space string index for outputting all long LEMs of a pattern with respect to a text given the matching statistics of the pattern with respect to the text. Here m is the length of the query, occ is the number of long LEMs outputted, and r is the number of runs in the BWT of the text. The O(r) space string index we describe relies on an adaptation of the move data structure by Nishimoto and Tabei. We are able to support LCP[i] queries in constant time given SA[i]. In other words, we answer PLCP[i] queries in constant time. These PLCP queries enable the efficient long LEM query. Long LEMs may provide useful similarity information between a pattern and a text that MEMs may ignore. This information is particularly useful in pangenome and biobank scale haplotype panel contexts.
Cite as

Ahsan Sanaullah, Degui Zhi, and Shaojie Zhang. An Efficient Data Structure and Algorithm for Long-Match Query in Run-Length Compressed BWT. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 17:1-17:25, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{sanaullah_et_al:LIPIcs.WABI.2025.17,
  author =	{Sanaullah, Ahsan and Zhi, Degui and Zhang, Shaojie},
  title =	{{An Efficient Data Structure and Algorithm for Long-Match Query in Run-Length Compressed BWT}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{17:1--17:25},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.17},
  URN =		{urn:nbn:de:0030-drops-239433},
  doi =		{10.4230/LIPIcs.WABI.2025.17},
  annote =	{Keywords: BWT, LEM, Long LEM, MEM, Run Length Compressed BWT, Move Data Structure, Pangenome}
}
Document
DOI: 10.4230/LIPIcs.WABI.2025.22
Design of Worst-Case-Optimal Spaced Seeds

Authors: Jens Zentgraf and Sven Rahmann

Published in: LIPIcs, Volume 344, 25th International Conference on Algorithms for Bioinformatics (WABI 2025)

Abstract
Read mapping (and alignment) is a fundamental problem in biological sequence analysis. For speed and computational efficiency, many popular read mappers tolerate only a few differences between the read and the corresponding part of the reference genome, which leads to reference bias: Reads with too many differences are not guaranteed to be mapped correctly or at all, because to even consider a genomic position, a sufficiently long exact match (seed) must exist. While pangenomes and their graph-based representations provide one way to avoid reference bias by enlarging the reference, we explore an orthogonal approach and consider stronger substitution-tolerant primitives, namely spaced seeds or gapped k-mers. Given two integers k ≤ w, one considers k selected positions, described by a mask, from each length-w window in a sequence. In the existing literature, masks with certain probabilistic guarantees have been designed for small values of k. Here, for the first time, we take a combinatorial approach from a worst-case perspective. For any mask, using integer linear programs, we find least favorable distributions of sequence changes in two different senses: (1) minimizing the number of unchanged windows; (2) minimizing the number of positions covered by unchanged windows. Then, among all masks or all symmetric masks of a given shape (k,w), we find the set of best masks that maximize these minima. As a result, we obtain robust masks, even for large numbers of changes. We illustrate the properties of these masks by constructing a challenging set of reads that contain many approximately equidistributed substitutions (but no indels) that many existing tools cannot map, even though they are in principle easily mappable (apart from the large number of changes) because they originate from selected non-repetitive regions of the human reference genome. We observe that the majority of these reads can be mapped with a simple alignment-free approach using chosen spaced masks, where seeding approaches based on contiguous k-mers fail.
Cite as

Jens Zentgraf and Sven Rahmann. Design of Worst-Case-Optimal Spaced Seeds. In 25th International Conference on Algorithms for Bioinformatics (WABI 2025). Leibniz International Proceedings in Informatics (LIPIcs), Volume 344, pp. 22:1-22:17, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{zentgraf_et_al:LIPIcs.WABI.2025.22,
  author =	{Zentgraf, Jens and Rahmann, Sven},
  title =	{{Design of Worst-Case-Optimal Spaced Seeds}},
  booktitle =	{25th International Conference on Algorithms for Bioinformatics (WABI 2025)},
  pages =	{22:1--22:17},
  series =	{Leibniz International Proceedings in Informatics (LIPIcs)},
  ISBN =	{978-3-95977-386-7},
  ISSN =	{1868-8969},
  year =	{2025},
  volume =	{344},
  editor =	{Brejov\'{a}, Bro\v{n}a and Patro, Rob},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2025.22},
  URN =		{urn:nbn:de:0030-drops-239488},
  doi =		{10.4230/LIPIcs.WABI.2025.22},
  annote =	{Keywords: Spaced seed, Gapped k-mer, Integer linear program (ILP), Worst-case design, Reference bias}
}
Document
Research
DOI: 10.4230/OASIcs.Grossi.2
On the Construction of Elastic Degenerate Strings

Authors: Nicola Rizzo, Veli Mäkinen, and Nadia Pisanti

Published in: OASIcs, Volume 132, From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday (2025)

Abstract
An elastic degenerate string (EDS) is a sequence of sets of strings. In the context of bioinformatics, EDSes can be used to represent the variations observed in a population from its consensus genome. Pattern matching and comparison problems on EDSes have been widely studied in the literature, but their construction has been largely omitted. We fill this gap by showing how algorithms originally developed for related problems of founder reconstruction can be adapted to minimize the total cardinality of the EDS sets and total length of the EDS strings in linear time, given suitable multiple alignments representing the input data.
Cite as

Nicola Rizzo, Veli Mäkinen, and Nadia Pisanti. On the Construction of Elastic Degenerate Strings. In From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 132, pp. 2:1-2:13, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{rizzo_et_al:OASIcs.Grossi.2,
  author =	{Rizzo, Nicola and M\"{a}kinen, Veli and Pisanti, Nadia},
  title =	{{On the Construction of Elastic Degenerate Strings}},
  booktitle =	{From Strings to Graphs, and Back Again: A Festschrift for Roberto Grossi's 60th Birthday},
  pages =	{2:1--2:13},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-391-1},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{132},
  editor =	{Conte, Alessio and Marino, Andrea and Rosone, Giovanna and Vitter, Jeffrey Scott},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Grossi.2},
  URN =		{urn:nbn:de:0030-drops-238014},
  doi =		{10.4230/OASIcs.Grossi.2},
  annote =	{Keywords: multiple sequence alignment, pattern matching, data structures, segmentation algorithms, founder reconstruction, dynamic programming, semi-dynamic range minimum queries, positional Burrows-Wheeler transform}
}
Document
DOI: 10.4230/OASIcs.Manzini.4
Wavelet Tree, Part II: Text Indexing

Authors: Paolo Ferragina, Raffaele Giancarlo, Roberto Grossi, Giovanna Rosone, Rossano Venturini, and Jeffrey Scott Vitter

Published in: OASIcs, Volume 131, The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday (2025)

Abstract
The Wavelet Tree data structure introduced in Grossi, Gupta, and Vitter [Grossi et al., 2003] is a space-efficient technique for rank and select queries that generalizes from binary symbols to an arbitrary multisymbol alphabet. Over the last two decades, it has become a pivotal tool in modern full-text indexing and data compression because of its properties and capabilities in compressing and indexing data, with many applications to information retrieval, genome analysis, data mining, and web search. In this paper, we survey the fascinating history and impact of Wavelet Trees; no doubt many more developments are yet to come. Our survey borrows some content from the authors' earlier works. This paper is divided into two parts: The first part gives a brief history of Wavelet Trees, including its varieties and practical implementations, which appears in the Festschrift dedicated to Roberto Grossi; the second part (this one) deals with Wavelet Tree-based text indexing and is included in the Festschrift dedicated to Giovanni Manzini.
Cite as

Paolo Ferragina, Raffaele Giancarlo, Roberto Grossi, Giovanna Rosone, Rossano Venturini, and Jeffrey Scott Vitter. Wavelet Tree, Part II: Text Indexing. In The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 131, pp. 4:1-4:10, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{ferragina_et_al:OASIcs.Manzini.4,
  author =	{Ferragina, Paolo and Giancarlo, Raffaele and Grossi, Roberto and Rosone, Giovanna and Venturini, Rossano and Vitter, Jeffrey Scott},
  title =	{{Wavelet Tree, Part II: Text Indexing}},
  booktitle =	{The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday},
  pages =	{4:1--4:10},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-390-4},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{131},
  editor =	{Ferragina, Paolo and Gagie, Travis and Navarro, Gonzalo},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Manzini.4},
  URN =		{urn:nbn:de:0030-drops-239127},
  doi =		{10.4230/OASIcs.Manzini.4},
  annote =	{Keywords: Wavelet tree, data compression, text indexing, compressed suffix array, Burrows-Wheeler transform, rank and select}
}
Document
DOI: 10.4230/OASIcs.Manzini.7
Algorithms for Computing Very Large BWTs: a Short Survey

Authors: Diego Díaz-Domínguez, Lavinia Egidi, Veronica Guerrini, Felipe A. Louza, and Giovanna Rosone

Published in: OASIcs, Volume 131, The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday (2025)

Abstract
The Burrows-Wheeler Transform (BWT) is a fundamental string transformation that, although initially introduced for data compression, has been extensively utilized across various domains, including text indexing and pattern matching within large datasets. Although the BWT construction is linear, the constants make the task impractical for large datasets, and as highlighted by Ferragina et al. [Paolo Ferragina et al., 2012], "to use it, one must first build it!". Thus, the construction of the BWT remains a significant challenge. For these reasons, during the past three decades there has been a succession of new algorithms for its construction using techniques that work in external memory or that use text compression. In this survey, we revise some of the most important advancements and tools presented in the past years for computing large BWTs exploiting external memory or text compression approaches without using additional information about the data.
Cite as

Diego Díaz-Domínguez, Lavinia Egidi, Veronica Guerrini, Felipe A. Louza, and Giovanna Rosone. Algorithms for Computing Very Large BWTs: a Short Survey. In The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 131, pp. 7:1-7:28, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{diazdominguez_et_al:OASIcs.Manzini.7,
  author =	{D{\'\i}az-Dom{\'\i}nguez, Diego and Egidi, Lavinia and Guerrini, Veronica and Louza, Felipe A. and Rosone, Giovanna},
  title =	{{Algorithms for Computing Very Large BWTs: a Short Survey}},
  booktitle =	{The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday},
  pages =	{7:1--7:28},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-390-4},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{131},
  editor =	{Ferragina, Paolo and Gagie, Travis and Navarro, Gonzalo},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Manzini.7},
  URN =		{urn:nbn:de:0030-drops-239151},
  doi =		{10.4230/OASIcs.Manzini.7},
  annote =	{Keywords: Burrows-Wheeler transform, Extended Burrows-Wheeler transform, external memory, text compression, longest common prefix}
}
Document
DOI: 10.4230/OASIcs.Manzini.12
Wheeler Graphs and Wheeler Languages

Authors: Nicola Cotumaccio, Giovanna D'Agostino, Daniel Gibney, Alberto Policriti, Nicola Prezza, and Sharma V. Thankachan

Published in: OASIcs, Volume 131, The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday (2025)

Abstract
Suffix sorting stands at the core of the most efficient solutions for indexed pattern matching: the suffix tree, the suffix array, compressed indexes based on the Burrows-Wheeler transform, and so on. In [Gagie, Manzini, Sirén, TCS 2017] this concept was extended to labeled graphs, obtaining the rich class of Wheeler graphs. This work opened a very fruitful line of research, ultimately generating results able to bridge the fields of compressed data structures, graph theory, and regular language theory. In a Wheeler graph, nodes are sorted according to the alphabetic order of their incoming labels, propagating this order through pairs of equally-labeled edges. This apparently-simple definition makes it possible to solve on Wheeler graphs problems (including, but not limited to: compression, subpath queries, NFA equivalence, determinization, minimization) that on general labeled graphs are extremely hard to solve, and induces a rich structure in the class of regular languages (Wheeler languages) recognized by automata whose state transition is a Wheeler graph. The goal of this survey is to provide a summary of (and intuitions behind) the results on Wheeler graphs that appeared in the literature since their introduction, in addition to a discussion of interesting problems that are still open in the field.
Cite as

Nicola Cotumaccio, Giovanna D'Agostino, Daniel Gibney, Alberto Policriti, Nicola Prezza, and Sharma V. Thankachan. Wheeler Graphs and Wheeler Languages. In The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 131, pp. 12:1-12:28, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{cotumaccio_et_al:OASIcs.Manzini.12,
  author =	{Cotumaccio, Nicola and D'Agostino, Giovanna and Gibney, Daniel and Policriti, Alberto and Prezza, Nicola and Thankachan, Sharma V.},
  title =	{{Wheeler Graphs and Wheeler Languages}},
  booktitle =	{The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday},
  pages =	{12:1--12:28},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-390-4},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{131},
  editor =	{Ferragina, Paolo and Gagie, Travis and Navarro, Gonzalo},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Manzini.12},
  URN =		{urn:nbn:de:0030-drops-239205},
  doi =		{10.4230/OASIcs.Manzini.12},
  annote =	{Keywords: Wheeler languages, Wheeler graphs, pattern matching, indexing, compressed data structures}
}
Document
DOI: 10.4230/OASIcs.Manzini.9
Search Schemes for Approximate Pattern Matching: An Overview

Authors: Lore Depuydt, Jan Fostier, Simon Gottlieb, Gregory Kucherov, Knut Reinert, and Luca Renders

Published in: OASIcs, Volume 131, The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday (2025)

Abstract
We provide a brief survey of results on solving the approximate pattern matching problem using search schemes, as introduced by Kucherov et al. (2016). We demonstrate that search schemes constitute a flexible and versatile tool that enable the specification of various search strategies, including several known filtering methods. We present approaches for designing efficient search schemes and for implementing them effectively. Finally, we conclude with experimental results comparing multiple search schemes on DNA sequencing data using the Columba software by Renders et al. (2021).
Cite as

Lore Depuydt, Jan Fostier, Simon Gottlieb, Gregory Kucherov, Knut Reinert, and Luca Renders. Search Schemes for Approximate Pattern Matching: An Overview. In The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 131, pp. 9:1-9:16, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{depuydt_et_al:OASIcs.Manzini.9,
  author =	{Depuydt, Lore and Fostier, Jan and Gottlieb, Simon and Kucherov, Gregory and Reinert, Knut and Renders, Luca},
  title =	{{Search Schemes for Approximate Pattern Matching: An Overview}},
  booktitle =	{The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday},
  pages =	{9:1--9:16},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-390-4},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{131},
  editor =	{Ferragina, Paolo and Gagie, Travis and Navarro, Gonzalo},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Manzini.9},
  URN =		{urn:nbn:de:0030-drops-239172},
  doi =		{10.4230/OASIcs.Manzini.9},
  annote =	{Keywords: FM-index, bidirectional index, approximate pattern matching, search scheme}
}
Document
DOI: 10.4230/OASIcs.Manzini.8
A Taxonomy of LCP-Array Construction Algorithms

Authors: Johannes Fischer and Enno Ohlebusch

Published in: OASIcs, Volume 131, The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday (2025)

Abstract
The combination of the suffix array and the LCP-array can be used to solve many string processing problems efficiently. We review some of the most important sequential LCP-array construction algorithms in random access memory.
Cite as

Johannes Fischer and Enno Ohlebusch. A Taxonomy of LCP-Array Construction Algorithms. In The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday. Open Access Series in Informatics (OASIcs), Volume 131, pp. 8:1-8:17, Schloss Dagstuhl – Leibniz-Zentrum für Informatik (2025)

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@InProceedings{fischer_et_al:OASIcs.Manzini.8,
  author =	{Fischer, Johannes and Ohlebusch, Enno},
  title =	{{A Taxonomy of LCP-Array Construction Algorithms}},
  booktitle =	{The Expanding World of Compressed Data: A Festschrift for Giovanni Manzini's 60th Birthday},
  pages =	{8:1--8:17},
  series =	{Open Access Series in Informatics (OASIcs)},
  ISBN =	{978-3-95977-390-4},
  ISSN =	{2190-6807},
  year =	{2025},
  volume =	{131},
  editor =	{Ferragina, Paolo and Gagie, Travis and Navarro, Gonzalo},
  publisher =	{Schloss Dagstuhl -- Leibniz-Zentrum f{\"u}r Informatik},
  address =	{Dagstuhl, Germany},
  URL =		{https://drops.dagstuhl.de/entities/document/10.4230/OASIcs.Manzini.8},
  URN =		{urn:nbn:de:0030-drops-239166},
  doi =		{10.4230/OASIcs.Manzini.8},
  annote =	{Keywords: longest common prefix array, suffix array, Burrows-Wheeler transform}
}
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